Skip to main content
Top
Published in: International Journal of Clinical Pharmacy 6/2009

01-12-2009 | Research Article

Improvement of diabetes indices of care by a short pharmaceutical care program

Authors: Mertkan Turnacilar, Mesut Sancar, Sule Apikoglu-Rabus, Mehmet Hursitoglu, Fikret Vehbi Izzettin

Published in: International Journal of Clinical Pharmacy | Issue 6/2009

Login to get access

Abstract

Objective Diabetes mellitus is a serious health problem associated with an increased mortality and morbidity. The association of improved glycemic control with sustained decrease in the rate of complications has been shown in randomized clinical trials. Pharmaceutical care is a relatively new concept in Turkey; yet, there are no recorded routine pharmaceutical care programs. Therefore, we aimed to assess the impact of a short pharmaceutical care program conducted in the community pharmacy setting, on the indices of diabetes care of type 2 diabetic patients, particularly those regarding glycemic control and high blood pressure management. Setting The study was carried out at eight community pharmacies in Pendik district of Istanbul. Method All patients who visited any of the eight pharmacies through the pre-determined 1-week period were questioned for the presence of type 2 diabetes. Patients who reported to be type 2 diabetic (n = 67) were informed about the study and invited to involve. During this prospective longitudinal study, pharmaceutical care was provided to the patients by the same clinical pharmacist. The 3 month pharmaceutical care period consisted of six pharmacy visits. Main outcome measure: The main outcome measures were the improvement in glycemic control and blood pressure control; while, weight control, self-monitoring of blood glucose, compliance and being under physician-control were also assessed. Results The study was conducted on 43 patients who accepted to involve. Fasting blood glucose was lowered by a mean of 23% over 3-months from an initial value of 167.2 mg/dl. Number of patients reaching the desired blood glucose goals increased from 16.3% to 39.5%. Systolic and diastolic blood pressures also significantly fell over 3 months (mean reductions were 10.9 mmHg for the systolic and 9.3 mmHg for the diastolic blood pressure). Number of patients reaching the desired blood pressure goal increased from 30.2% to 51.2%. Conclusion Our short-course pharmaceutical care program yielded measurable improvements in clinical indicators of diabetes and comorbidity management. The results suggest that the pharmacist is a beneficial key component of integrated care for patients with type 2 diabetes. We think that the positive results observed in this first reported pharmaceutical care program on diabetes in Turkey can be motivating and encouraging for all community pharmacists.
Literature
1.
go back to reference Matzer S, Leiter L, Daneman D, Gerstein H, Lau D, Ludwig S, et al. Clinical practice guidelines for the management of diabetes in Canada. CMAJ. 1998;159:1–29. Matzer S, Leiter L, Daneman D, Gerstein H, Lau D, Ludwig S, et al. Clinical practice guidelines for the management of diabetes in Canada. CMAJ. 1998;159:1–29.
2.
go back to reference American Diabetes Association: Implications of the diabetes control and complications trial. Diabetes Care 2002; 25: 25–7. American Diabetes Association: Implications of the diabetes control and complications trial. Diabetes Care 2002; 25: 25–7.
3.
go back to reference Abuissa H, Bel DS, O’Keefe JH Jr. Strategies to prevent type 2 diabetes. Curr Med Res Opin. 2005;21:1107–14.CrossRefPubMed Abuissa H, Bel DS, O’Keefe JH Jr. Strategies to prevent type 2 diabetes. Curr Med Res Opin. 2005;21:1107–14.CrossRefPubMed
4.
go back to reference Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, et al. The seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA. 2003;289:2560–72.CrossRefPubMed Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, et al. The seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA. 2003;289:2560–72.CrossRefPubMed
5.
go back to reference The Diabetes Control and Complications Trial Research Group: The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993; 329: 977–86. The Diabetes Control and Complications Trial Research Group: The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993; 329: 977–86.
6.
go back to reference The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group: Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy. N Engl J Med. 2000; 342: 381–9. The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group: Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy. N Engl J Med. 2000; 342: 381–9.
7.
go back to reference UK Prospective Diabetes Study (UKPDS) Group: intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet. 1998; 352: 837–53. UK Prospective Diabetes Study (UKPDS) Group: intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet. 1998; 352: 837–53.
8.
go back to reference UK Prospective Diabetes Study (UKPDS) Group: Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998; 352: 854–65. UK Prospective Diabetes Study (UKPDS) Group: Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998; 352: 854–65.
9.
go back to reference UK Prospective Diabetes Study Group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. BMJ. 1998; 317: 703–13. UK Prospective Diabetes Study Group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. BMJ. 1998; 317: 703–13.
10.
go back to reference Hansson L, Zanchetti A, Carruthers SG, Dahlof B, Elmfeldt D, Julius S, et al. HOT Study Group: effects of intensive blood pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. Lancet. 1998;351:1755–62.CrossRefPubMed Hansson L, Zanchetti A, Carruthers SG, Dahlof B, Elmfeldt D, Julius S, et al. HOT Study Group: effects of intensive blood pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. Lancet. 1998;351:1755–62.CrossRefPubMed
11.
go back to reference Adler AI, Stratton IM, Neil HA, Yudkin JS, Matthews DR, Cull CA, et al. Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study. BMJ. 2000;321:412–9.CrossRefPubMed Adler AI, Stratton IM, Neil HA, Yudkin JS, Matthews DR, Cull CA, et al. Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study. BMJ. 2000;321:412–9.CrossRefPubMed
12.
go back to reference Garção JA, Cabrita J. Evaluation of a pharmaceutical care program for hypertensive patients in rural Portugal. J Am Pharm Assoc. 2002;42:858–64.CrossRef Garção JA, Cabrita J. Evaluation of a pharmaceutical care program for hypertensive patients in rural Portugal. J Am Pharm Assoc. 2002;42:858–64.CrossRef
13.
go back to reference Gonzalez-Martin G, Joo I, Sanchez I. Evaluation of the impact of a pharmaceutical care program in children with asthma. Patient Educ Couns. 2003;49:13–8.CrossRefPubMed Gonzalez-Martin G, Joo I, Sanchez I. Evaluation of the impact of a pharmaceutical care program in children with asthma. Patient Educ Couns. 2003;49:13–8.CrossRefPubMed
14.
go back to reference Paulos CP, Nygren CE, Celedon C, Carcama CA. Impact of a pharmaceutical care program in a community pharmacy on patients with dyslipidemia. Ann Pharmacother. 2005;39:939–43.CrossRefPubMed Paulos CP, Nygren CE, Celedon C, Carcama CA. Impact of a pharmaceutical care program in a community pharmacy on patients with dyslipidemia. Ann Pharmacother. 2005;39:939–43.CrossRefPubMed
15.
go back to reference Clark PM, Karagoz T, Apikoglu-Rabus S, Izzettin FV. Effect of pharmacist-led patient education on adherence to tuberculosis treatment. Am J Health-Syst Pharm. 2007;64:497–506.CrossRefPubMed Clark PM, Karagoz T, Apikoglu-Rabus S, Izzettin FV. Effect of pharmacist-led patient education on adherence to tuberculosis treatment. Am J Health-Syst Pharm. 2007;64:497–506.CrossRefPubMed
16.
go back to reference Coast-Senior EA, Kroner BA, Kelley CL, Trilli LE. Management of patient with type 2 diabetes by pharmacists in primary care clinics. Ann Pharmacother. 1998;32:636–41.CrossRefPubMed Coast-Senior EA, Kroner BA, Kelley CL, Trilli LE. Management of patient with type 2 diabetes by pharmacists in primary care clinics. Ann Pharmacother. 1998;32:636–41.CrossRefPubMed
17.
go back to reference Jaber LA, Halapi H, Fernet M, Tummalapalli S, Diwakaran H. Evaluation of a pharmaceutical care model on diabetes management. Ann Pharmacother. 1996;30:238–43.PubMed Jaber LA, Halapi H, Fernet M, Tummalapalli S, Diwakaran H. Evaluation of a pharmaceutical care model on diabetes management. Ann Pharmacother. 1996;30:238–43.PubMed
18.
go back to reference Berringer R, Shibley MC, Cary CC, Pugh CB, Powers PA, Rafi JA. Outcomes of a community pharmacy-based diabetes monitoring program. J Am Pharm Assoc. 1999;39:791–7. Berringer R, Shibley MC, Cary CC, Pugh CB, Powers PA, Rafi JA. Outcomes of a community pharmacy-based diabetes monitoring program. J Am Pharm Assoc. 1999;39:791–7.
19.
go back to reference Van Veldhuizen-Scott MK, Widmer LB, Stacy SA, Popovich NG. Developing and implementing a pharmaceutical care model in an ambulatory care setting for patients with diabetes. Diabetes Educ. 1995;21:117–23.CrossRefPubMed Van Veldhuizen-Scott MK, Widmer LB, Stacy SA, Popovich NG. Developing and implementing a pharmaceutical care model in an ambulatory care setting for patients with diabetes. Diabetes Educ. 1995;21:117–23.CrossRefPubMed
20.
go back to reference Wermeille J, Bennie M, Brown I, McKnight J. Pharmaceutical care model for patients with type 2 diabetes: integration of the community pharmacist into the diabetes team-a pilot study. Pharm World Sci. 2004;26:18–25.CrossRefPubMed Wermeille J, Bennie M, Brown I, McKnight J. Pharmaceutical care model for patients with type 2 diabetes: integration of the community pharmacist into the diabetes team-a pilot study. Pharm World Sci. 2004;26:18–25.CrossRefPubMed
21.
go back to reference Anaya JP, Rivera JO, Lawson K, Garcia J, Luna J Jr, Ortiz M. Evaluation of pharmacist-managed diabetes mellitus under a collaborative drug therapy agreement. Am J Health Syst Pharm. 2008;65:1841–5.CrossRefPubMed Anaya JP, Rivera JO, Lawson K, Garcia J, Luna J Jr, Ortiz M. Evaluation of pharmacist-managed diabetes mellitus under a collaborative drug therapy agreement. Am J Health Syst Pharm. 2008;65:1841–5.CrossRefPubMed
22.
go back to reference Morello CM, Zadvorny EB, Cording MA, Suemoto RT, Skog J, Harari A. Development and clinical outcomes of pharmacist-managed diabetes care clinics. Am J Health Syst Pharm. 2006;63:1325–31.CrossRefPubMed Morello CM, Zadvorny EB, Cording MA, Suemoto RT, Skog J, Harari A. Development and clinical outcomes of pharmacist-managed diabetes care clinics. Am J Health Syst Pharm. 2006;63:1325–31.CrossRefPubMed
23.
go back to reference Irons BK, Seifert CF, Horton NA. Quality of care of a pharmacist-managed diabetes service compared to usual care in an indigent clinic. Diabetes Technol Ther. 2008;10:220–6.CrossRefPubMed Irons BK, Seifert CF, Horton NA. Quality of care of a pharmacist-managed diabetes service compared to usual care in an indigent clinic. Diabetes Technol Ther. 2008;10:220–6.CrossRefPubMed
24.
go back to reference Fera T, Bluml BM, Ellis WM, Schaller CW, Garrett DG. The diabetes ten city challenge: interim clinical and humanistic outcomes of a multi-site community pharmacy diabetes care program. J Am Pharm Assoc. 2008;48:181–90.CrossRef Fera T, Bluml BM, Ellis WM, Schaller CW, Garrett DG. The diabetes ten city challenge: interim clinical and humanistic outcomes of a multi-site community pharmacy diabetes care program. J Am Pharm Assoc. 2008;48:181–90.CrossRef
25.
go back to reference Cranor CW, Christensen DB. The Asheville Project: short-term outcomes of a community pharmacy diabetes care program. J Am Pharm Assoc. 2003;43:149–59.CrossRef Cranor CW, Christensen DB. The Asheville Project: short-term outcomes of a community pharmacy diabetes care program. J Am Pharm Assoc. 2003;43:149–59.CrossRef
26.
go back to reference Cranor CW, Bunting BA, Christensen DB. The Asheville Project: long-term clinical and economic outcomes of a community pharmacy diabetes care program. J Am Pharm Assoc. 2003;43:173–84.CrossRef Cranor CW, Bunting BA, Christensen DB. The Asheville Project: long-term clinical and economic outcomes of a community pharmacy diabetes care program. J Am Pharm Assoc. 2003;43:173–84.CrossRef
27.
go back to reference Cioffi ST, Caron MF, Kalus JS, Hill P, Buckley TE. Glycosylated hemoglobin, cardiovascular, and renal outcomes in a pharmacist-managed clinic. Ann Pharmacother. 2004;38:771–5.CrossRefPubMed Cioffi ST, Caron MF, Kalus JS, Hill P, Buckley TE. Glycosylated hemoglobin, cardiovascular, and renal outcomes in a pharmacist-managed clinic. Ann Pharmacother. 2004;38:771–5.CrossRefPubMed
28.
go back to reference Choe HM, Mitrovich S, Dubay D, Hayward RA, Krein SL, Vijan S. Proactive case management of high-risk patients with type 2 diabetes mellitus by a clinical pharmacist: a randomized controlled trial. Am J Manag Care. 2005;11:253–60.PubMed Choe HM, Mitrovich S, Dubay D, Hayward RA, Krein SL, Vijan S. Proactive case management of high-risk patients with type 2 diabetes mellitus by a clinical pharmacist: a randomized controlled trial. Am J Manag Care. 2005;11:253–60.PubMed
29.
go back to reference Suppapitiporn S, Chindavijak B, Onsanit S. Effect of diabetes drug counselling by pharmacist, diabetic disease booklet and special medication containers on glycemic control of type 2 diabetes mellitus: a randomized controlled trial. J Med Assoc Thai. 2005;88:S134–41.PubMed Suppapitiporn S, Chindavijak B, Onsanit S. Effect of diabetes drug counselling by pharmacist, diabetic disease booklet and special medication containers on glycemic control of type 2 diabetes mellitus: a randomized controlled trial. J Med Assoc Thai. 2005;88:S134–41.PubMed
30.
go back to reference Brooks AD, Rihani RS, Derus CL. Pharmacist membership in a medical group’s diabetes health management program. Am J Health Syst Pharm. 2007;64:617–21.CrossRefPubMed Brooks AD, Rihani RS, Derus CL. Pharmacist membership in a medical group’s diabetes health management program. Am J Health Syst Pharm. 2007;64:617–21.CrossRefPubMed
31.
go back to reference Hepler CD, Strand LM. Opportunities and responsibilities in pharmaceutical care. Am J Hosp Pharm. 1990;47:533–43.PubMed Hepler CD, Strand LM. Opportunities and responsibilities in pharmaceutical care. Am J Hosp Pharm. 1990;47:533–43.PubMed
32.
go back to reference Cipolle RJ, Strand LM, Morley PC. Pharmaceutical care practice: the clinician’s guide 2nd Edition The McGraw-Hill Companies, Inc. 2004 USA. Cipolle RJ, Strand LM, Morley PC. Pharmaceutical care practice: the clinician’s guide 2nd Edition The McGraw-Hill Companies, Inc. 2004 USA.
33.
go back to reference Al-Mazroui NR, Kamal MM, Ghabash NM, Yacout TA, Kole PL, McElnay JC. Influence of pharmaceutical care on health outcomes in patients with type 2 diabetes mellitus. Br J Clin Pharmacol. 2009;67:547–57.CrossRefPubMed Al-Mazroui NR, Kamal MM, Ghabash NM, Yacout TA, Kole PL, McElnay JC. Influence of pharmaceutical care on health outcomes in patients with type 2 diabetes mellitus. Br J Clin Pharmacol. 2009;67:547–57.CrossRefPubMed
34.
go back to reference Rohlfing CL, Wiedmeyer HM, Little RR, England JD, Tennill A, Goldstein DE. Defining the relationship between plasma glucose and HbA1c, analysis of glucose profiles and HbA1c in the Diabetes Control and Complications Trial. Diabetes Care. 2002;25:275–8.CrossRefPubMed Rohlfing CL, Wiedmeyer HM, Little RR, England JD, Tennill A, Goldstein DE. Defining the relationship between plasma glucose and HbA1c, analysis of glucose profiles and HbA1c in the Diabetes Control and Complications Trial. Diabetes Care. 2002;25:275–8.CrossRefPubMed
35.
go back to reference McLean DL, McAlister FA, Johnson JA, King KM, Makowsky MJ, Jones CA, et al. SCRIP-HTN Investigators: A randomized trial of the effect of community pharmacist and nurse care on improving blood pressure management in patients with diabetes mellitus: study of cardiovascular risk intervention by pharmacists-hypertension (SCRIP-HTN). Arch Intern Med. 2008;24(168):2355–61.CrossRef McLean DL, McAlister FA, Johnson JA, King KM, Makowsky MJ, Jones CA, et al. SCRIP-HTN Investigators: A randomized trial of the effect of community pharmacist and nurse care on improving blood pressure management in patients with diabetes mellitus: study of cardiovascular risk intervention by pharmacists-hypertension (SCRIP-HTN). Arch Intern Med. 2008;24(168):2355–61.CrossRef
36.
go back to reference Scott DM, Boyd ST, Stephan M, Augustine SC, Reardon TP. Outcomes of pharmacist-managed diabetes care services in a community health center. Am J Health Syst Pharm. 2006;63:2116–22.CrossRefPubMed Scott DM, Boyd ST, Stephan M, Augustine SC, Reardon TP. Outcomes of pharmacist-managed diabetes care services in a community health center. Am J Health Syst Pharm. 2006;63:2116–22.CrossRefPubMed
37.
go back to reference Vivian EM. Improving blood pressure control in a pharmacists-managed hypertension clinic. Pharmacotherapy. 2002;22:1533–40.CrossRefPubMed Vivian EM. Improving blood pressure control in a pharmacists-managed hypertension clinic. Pharmacotherapy. 2002;22:1533–40.CrossRefPubMed
38.
go back to reference Ahrens RA, Hower M, Best AM. Effects of weight reduction interventions by community pharmacists. J Am Pharm Assoc. 2003;43:583–90.CrossRef Ahrens RA, Hower M, Best AM. Effects of weight reduction interventions by community pharmacists. J Am Pharm Assoc. 2003;43:583–90.CrossRef
39.
go back to reference Zillich AJ, Ryan M, Adams A, Yeager B, Farris K. Effectiveness of a pharmacist-based smoking-cessation program and its impact on quality of life. Pharmacotherapy. 2003;22:759–65.CrossRef Zillich AJ, Ryan M, Adams A, Yeager B, Farris K. Effectiveness of a pharmacist-based smoking-cessation program and its impact on quality of life. Pharmacotherapy. 2003;22:759–65.CrossRef
40.
go back to reference Clifford RM, Davis WA, Batty KT, Davis TME. Effect of a pharmaceutical care program on vascular risk factors in type 2 diabetes. The Fremantle Diabetes Study. Diabetes Care. 2005;28:771–6.CrossRefPubMed Clifford RM, Davis WA, Batty KT, Davis TME. Effect of a pharmaceutical care program on vascular risk factors in type 2 diabetes. The Fremantle Diabetes Study. Diabetes Care. 2005;28:771–6.CrossRefPubMed
Metadata
Title
Improvement of diabetes indices of care by a short pharmaceutical care program
Authors
Mertkan Turnacilar
Mesut Sancar
Sule Apikoglu-Rabus
Mehmet Hursitoglu
Fikret Vehbi Izzettin
Publication date
01-12-2009
Publisher
Springer Netherlands
Published in
International Journal of Clinical Pharmacy / Issue 6/2009
Print ISSN: 2210-7703
Electronic ISSN: 2210-7711
DOI
https://doi.org/10.1007/s11096-009-9333-9

Other articles of this Issue 6/2009

International Journal of Clinical Pharmacy 6/2009 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.