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Immunologic Research
Published in: Immunologic Research 1-2/2015

01-02-2015 | DIAGNOSTICS AND ENVIRONMENTAL FACTORS

Importance of intestinal microenvironment in development of arthritis. A systematic review

Authors: Anna Bazsó, Péter Szodoray, Gábor Sütő, Yehuda Shoenfeld, Gyula Poór, Emese Kiss

Published in: Immunologic Research | Issue 1-2/2015

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Abstract

A strong connection between spondylarthropathies and inflammatory bowel diseases (IBD) is well established. About 10–15 % of IBD are associated with different forms of spondylarthritis. Arthritis can be manifested as axial, peripheral form or both. The primary functions of the gastrointestinal tract are digestion and absorption of nutrients, electrocytes and maintenance of water homoeostasis. The anatomic and functional lesions could lead to the development of IBD based on molecular mimicry and bystander effects. The mechanism of the macromolecules is uptaken may affect intestinal and extraintestinal manifestation in genetically susceptible individuals by gut-associated lymphoid tissue, the interplay between innate and adaptive immunity and the neuroendocrine network.
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Metadata
Title
Importance of intestinal microenvironment in development of arthritis. A systematic review
Authors
Anna Bazsó
Péter Szodoray
Gábor Sütő
Yehuda Shoenfeld
Gyula Poór
Emese Kiss
Publication date
01-02-2015
Publisher
Springer US
Published in
Immunologic Research / Issue 1-2/2015
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-014-8593-1

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