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Heart Failure Reviews
Published in: Heart Failure Reviews 1/2008

01-02-2008

Implications of chronic heart failure on peripheral vasculature and skeletal muscle before and after exercise training

Authors: Brian D. Duscha, P. Christian Schulze, Jennifer L. Robbins, Daniel E. Forman

Published in: Heart Failure Reviews | Issue 1/2008

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Abstract

 The pathophysiology of chronic heart failure (CHF) is typically conceptualized in terms of cardiac dysfunction. However, alterations in peripheral blood flow and intrinsic skeletal muscle properties are also now recognized as mechanisms for exercise intolerance that can be modified by therapeutic exercise. This overview focuses on blood delivery, oxygen extraction and utilization that result from heart failure. Related features of inflammation, changes in skeletal muscle signaling pathways, and vulnerability to skeletal muscle atrophy are discussed. Specific focus is given to the ways in which perfusion and skeletal muscle properties affect exercise intolerance and how peripheral improvements following exercise training increase aerobic capacity. We also identify gaps in the literature that may constitute priorities for further investigation.
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Metadata
Title
Implications of chronic heart failure on peripheral vasculature and skeletal muscle before and after exercise training
Authors
Brian D. Duscha
P. Christian Schulze
Jennifer L. Robbins
Daniel E. Forman
Publication date
01-02-2008
Publisher
Springer US
Published in
Heart Failure Reviews / Issue 1/2008
Print ISSN: 1382-4147
Electronic ISSN: 1573-7322
DOI
https://doi.org/10.1007/s10741-007-9056-8

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