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01-10-2018 | Original Article

Impact of the triglyceride level on coronary plaque components in female patients with coronary artery disease treated with statins

Authors: Motoki Yamashita, Atsushi Iwata, Yuta Kato, Makito Futami, Satoshi Imaizumi, Takashi Kuwano, Amane Ike, Makoto Sugihara, Hiroaki Nishikawa, Bo Zhang, Shin’ichiro Yasunaga, Keijiro Saku, Shin-ichiro Miura

Published in: Heart and Vessels | Issue 10/2018

Abstract

Several studies have reported that elevated triglyceride (TG) levels may be more strongly associated with an increased risk of coronary artery disease (CAD) in females than in males. We examined gender differences in the relationship between TG levels and coronary atherosclerosis using integrated backscatter intravascular ultrasound (IB IVUS) in CAD patients treated with statins. Three hundred seventy-eight CAD patients (105 females and 273 males) who underwent percutaneous coronary intervention using IB IVUS, and who were already receiving statin treatment, were included. Gray-scale and IB IVUS examinations were performed for the non-culprit segment of a coronary artery and fasting serum TG concentrations were measured. We found that TG levels were significantly correlated with increased lipid (r = 0.40, p < 0.001) and decreased fibrous (r = − 0.37, p < 0.001) plaque components in females, but not in males. Low-density lipoprotein cholesterol and high-density lipoprotein cholesterol levels were not related to either the gray-scale or IB IVUS parameters in both genders. After adjustment for conventional coronary risk factors by a multivariate stepwise regression analysis, higher TG levels in females were independently associated with increased lipid (β = 0.31, p< 0.001) contents in coronary plaques. In conclusion, among CAD patients treated with statins, TG levels were associated with lipid-rich coronary plaques in females, but not in males. TG levels may be more important indicators of residual risk after statin treatment in females than in males.

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Title: Impact of the triglyceride level on coronary plaque components in female patients with coronary artery disease treated with statins
Authors: Motoki Yamashita
Atsushi Iwata
Yuta Kato
Makito Futami
Satoshi Imaizumi
Takashi Kuwano
Amane Ike
Makoto Sugihara
Hiroaki Nishikawa
Bo Zhang
Shin’ichiro Yasunaga
Keijiro Saku
Shin-ichiro Miura
Publication date: 01-10-2018
Publisher: Springer Japan
Published in: Heart and Vessels / Issue 10/2018
Print ISSN: 0910-8327
Electronic ISSN: 1615-2573
DOI: https://doi.org/10.1007/s00380-018-1173-x

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Impact of the triglyceride level on coronary plaque components in female patients with coronary artery disease treated with statins

Abstract

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