Impact of subclinical hypothyroidism with TSH ≤10 mIU/L on glomerular filtration rate in adult women without known kidney disease

Excerpt

Subclinical hypothyroidism (SCH) is a common condition in adults, especially in women. Although not considered by current guidelines in the treatment decision of SCH [1‐5], concern exists regarding the association with decreased glomerular filtration rate (GFR). However, in the absence of overt hypothyroidism (TSH >20 mIU/L or low T4), TSH elevation might be a consequence of decreased GFR and does not reflect true thyroid dysfunction [1, 6]. Although SCH has a negative impact on GFR, this has been suggested particularly in patients with established kidney disease [7‐12] or associated conditions that are also known to compromise renal function, such as diabetes mellitus and arterial hypertension [7, 8, 10, 13]. The repercussion of SCH on GFR in adults without known kidney disease or risk conditions for renal dysfunction is less studied [14]. …