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Critical Care
Published in: Critical Care 1/2011

Open Access 01-02-2011 | Poster presentation

Impact of pro-domain stability of matrix metalloproteinase-8 on the outcome of sepsis

Authors: J McLaughlin, J Rella, A Bakan, L Kong, L Zhu, D Frederick, S Yende, R Ferrell, I Bahar, S Shapiro, D Angus, A Kaynar

Published in: Critical Care | Special Issue 1/2011

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Excerpt

Animal studies suggest matrix metalloproteinase-8 (MMP8) (neutrophil collagenase) impairs neutrophil (PMN) recruitment in inflammation; in humans, MMP8 has been associated with inflammation. We hypothesized that septic patients with single nucleotide polymorphisms (SNPs) in the MMP8 promoter region will have a survival advantage, and this advantage is due to differences in MMP8 enzymatic activity and not MMP8 levels. …
Metadata
Title
Impact of pro-domain stability of matrix metalloproteinase-8 on the outcome of sepsis
Authors
J McLaughlin
J Rella
A Bakan
L Kong
L Zhu
D Frederick
S Yende
R Ferrell
I Bahar
S Shapiro
D Angus
A Kaynar
Publication date
01-02-2011
Publisher
BioMed Central
Published in
Critical Care / Issue Special Issue 1/2011
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc9698

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