Published in:
Open Access
01-02-2011 | Poster presentation
Single-dose application of antithrombin III as alternative anticoagulation during extracorporeal therapy in critically ill patients with advanced liver cirrhosis: a retrospective data analysis
Authors:
R Brunner, C Madl, W Druml, U Holzinger
Published in:
Critical Care
|
Special Issue 1/2011
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Excerpt
Adequate anticoagulation is essential to achieve efficient and cost-effective renal and liver replacement therapy. However, critically ill patients with advanced liver cirrhosis are associated with low antithrombin III (ATIII) serum levels and increased tendency to both coagulation and bleeding disorder. Thus, we hypothesized that single-dose application of antithrombin III prolongs filter lifetime during renal and liver replacement therapy in critically ill patients with advanced liver cirrhosis without causing additional bleeding problems. …