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Clinical and Experimental Nephrology
Published in: Clinical and Experimental Nephrology 3/2016

01-06-2016 | Original Article

Impact of non-invasive cardiovascular screening programs as a predictor of cardiovascular events among asymptomatic chronic kidney disease patients

Authors: Akihiro Sawai, Yoshinari Yasuda, Susumu Suzuki, Hideki Ishii, Motomitsu Goto, Sawako Kato, Mutsuharu Hayashi, Shoichi Maruyama, Toyoaki Murohara, Yutaka Oiso, Seiichi Matsuo

Published in: Clinical and Experimental Nephrology | Issue 3/2016

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Abstract

Background

The clinical usefulness of physiological and radiological examinations for cardiovascular disease (CVD) risk stratification has not been fully demonstrated in chronic kidney disease (CKD) patients. In the present study, predictive values of CVD were investigated among asymptomatic CKD patients by comprehensive and non-invasive CVD screening programs.

Methods

We prospectively evaluated 139 asymptomatic CKD patients. All patients were examined by comprehensive and non-invasive CVD risk screening programs that included carotid ultrasonography, coronary artery calcification score (CACS), pulse wave velocity, and flow-mediated vasodilation, and their associations with major adverse cardiovascular events (MACEs) were analyzed.

Results

During the median follow-up of 32.3 months, 13 MACEs were observed. Among all CVD screening examinations, severity of the carotid plaque score (PS) and CACS was significantly higher in the MACE group than in the MACE-free group (11.3 ± 5.8 versus 6.1 ± 5.3, P = 0.001 and 657 versus 74, P = 0.020, respectively). Kaplan–Meier curves for the incidences of MACEs classified according to the combination of carotid PS and CACS showed that severe carotid PS and severe CACS groups had the highest event rate in comparison with the groups without any of these (29.9, 11.9, and 3.6 %, respectively, P < 0.001).

Conclusions

In this long-term follow-up analysis, the combination of carotid atherosclerosis and CACS was a useful and non-invasive screening tool for predicting cardiovascular events among asymptomatic CKD patients.
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Metadata
Title
Impact of non-invasive cardiovascular screening programs as a predictor of cardiovascular events among asymptomatic chronic kidney disease patients
Authors
Akihiro Sawai
Yoshinari Yasuda
Susumu Suzuki
Hideki Ishii
Motomitsu Goto
Sawako Kato
Mutsuharu Hayashi
Shoichi Maruyama
Toyoaki Murohara
Yutaka Oiso
Seiichi Matsuo
Publication date
01-06-2016
Publisher
Springer Japan
Published in
Clinical and Experimental Nephrology / Issue 3/2016
Print ISSN: 1342-1751
Electronic ISSN: 1437-7799
DOI
https://doi.org/10.1007/s10157-015-1169-0

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