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01-12-2012 | Cardiac

Impact of iterative reconstruction on CNR and SNR in dynamic myocardial perfusion imaging in an animal model

Authors: B. M. Gramer, D. Muenzel, V. Leber, A.-K. von Thaden, H. Feussner, A. Schneider, M. Vembar, N. Soni, E. J. Rummeny, A. M. Huber

Published in: European Radiology | Issue 12/2012

Abstract

Objectives

To evaluate a new iterative reconstruction (IR) algorithm for radiation dose, image quality (IQ), signal-to-noise-ratio (SNR), and contrast-to-noise-ratio (CNR) in multidetector computed tomography (MDCT) dynamic myocardial perfusion imaging (MPI).

Methods

ECG-gated 256-slice MDCT dynamic MPI was performed in six pigs after subtotal balloon occlusion of one artery. Two 100 kVp protocols were compared: high dose (HD): 150 mAs; low dose (LD): 100 mAs. HD images were reconstructed with filtered back projection (FBP), LD images with FBP and different strengths of IR (L1, L4, and L7). IQ (5-point scale), SNR, and CNR (ischemic vs. normal myocardium) values derived from the HD (FBP) images and the different LD images were compared.

Results

Mean SNR values for myocardium were 16.3, 11.3, 13.1, 17.1, and 28.9 for the HD, LD (FBP), LD (L1), LD (L4), and LD (L7) reconstructions, respectively. Mean CNR values were 8.9, 6.3, 7.8, 9.3, and 12.8. IQ was scored as 4.6, 3.3, 4.4, 4.7, and 3.4, respectively. A significant loss of IQ was observed for the LD (L7) images compared to the HD (FBP) images (P < 0.05).

Conclusion

Appropriate levels of iterative reconstruction can improve SNR and CNR, facilitating radiation dose savings in CT-MPI without influencing diagnostic quality.

Key Points

• Iterative reconstruction (IR) can reduce radiation dose in myocardial perfusion CT.

• Our study also demonstrated improvements in image quality (noise, SNR, and CNR).

• Dynamic CT-MPI could help determine the hemodynamic significance of coronary artery disease.

• With dynamic CT MPI, myocardial blood flow can be determined quantitatively.

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Title: Impact of iterative reconstruction on CNR and SNR in dynamic myocardial perfusion imaging in an animal model
Authors: B. M. Gramer
D. Muenzel
V. Leber
A.-K. von Thaden
H. Feussner
A. Schneider
M. Vembar
N. Soni
E. J. Rummeny
A. M. Huber
Publication date: 01-12-2012
Publisher: Springer-Verlag
Published in: European Radiology / Issue 12/2012
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-012-2525-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Impact of iterative reconstruction on CNR and SNR in dynamic myocardial perfusion imaging in an animal model

Abstract

Objectives

Methods

Results

Conclusion

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusion

Key Points

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