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Seminars in Immunopathology
Published in: Seminars in Immunopathology 2/2008

01-04-2008 | Review

Immunopathological aspects of age-related macular degeneration

Authors: Mrinali Patel, Chi-Chao Chan

Published in: Seminars in Immunopathology | Issue 2/2008

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Abstract

Age-related macular degeneration (AMD) represents a leading cause of blindness worldwide. While the clinical and histopathological aspects of AMD are well characterized, its etiology and pathogenesis remain unclear. Recent findings suggest a role for immunologic processes in AMD pathogenesis, including the age-related generation of extracellular deposits inside the Brusch membrane and beneath the retinal pigment epithelium, recruitment of macrophages for clearance of these deposits, complement activation, recruitment of tissue-destructive macrophages, microglial activation and accumulation, and proinflammatory effects of chronic inflammation by Chlamydia pneumoniae. This review discusses the evidence for the role of inflammation in human AMD and in animal models of AMD.
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Metadata
Title
Immunopathological aspects of age-related macular degeneration
Authors
Mrinali Patel
Chi-Chao Chan
Publication date
01-04-2008
Publisher
Springer-Verlag
Published in
Seminars in Immunopathology / Issue 2/2008
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-008-0112-9

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