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European Journal of Medical Research
Published in: European Journal of Medical Research 4/2010

01-12-2010 | Case report

Squamous odontogenic tumor of the mandible: a case report demonstrating immunoexpression of Notch1, 3, 4, Jagged1 and delta1

Authors: CH Siar, K Nakano, KH Ng, M Tomida, H Nagatsuka, T Kawakami

Published in: European Journal of Medical Research | Issue 4/2010

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Abstract

Background

Squamous odontogenic tumor (SOT) is a rare benign odontogenic epithelial neoplasm. A slow-growing painless expansive swelling is the common presenting symptom. Histopathologically, SOT can be easily misdiagnosed as an acanthomatous ameloblastoma. Although Notch receptors and ligands have been shown to play a role in cell fate decisions in ameloblastomas, the role of these cell signaling molecules in SOT is unknown.

Case report

This paper describes a case of SOT affecting the anterior mandible of a 10-year-old Indian female. The patient was treated by local surgical excision and there has been no follow-up clinical record of recurrence 5 years after primary treatment. Histopathological examination revealed a solid, locally-infiltrative neoplasm composed of bland-looking squamatoid islands scattered in a mature fibrous connective tissue stroma and the diagnosis was SOT. Immunohistochemical evaluation showed positive reactivity of varying intensity in the neoplastic epithelial cells for Notch1, Notch3, Notch4, and their ligands Jagged1 and Delta1. Expression patterns showed considerable overlap. No immunoreactivity was detected for Notch2 and Jagged2.

Conclusions

Present findings suggest that Notch receptors and their ligands play differential roles in the cytodifferentiation of SOT.
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Metadata
Title
Squamous odontogenic tumor of the mandible: a case report demonstrating immunoexpression of Notch1, 3, 4, Jagged1 and delta1
Authors
CH Siar
K Nakano
KH Ng
M Tomida
H Nagatsuka
T Kawakami
Publication date
01-12-2010
Publisher
BioMed Central
Published in
European Journal of Medical Research / Issue 4/2010
Electronic ISSN: 2047-783X
DOI
https://doi.org/10.1186/2047-783X-15-4-180

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