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Clinical Autonomic Research
Published in: Clinical Autonomic Research 4/2013

01-08-2013 | Research Article

Imidafenacin on bladder and cognitive function in neurologic OAB patients

Authors: Ryuji Sakakibara, Fuyuki Tateno, Masashi Yano, Osamu Takahashi, Megumi Sugiyama, Takeshi Ogata, Hiroyuki Haruta, Masahiko Kishi, Yohei Tsuyusaki, Tatsuya Yamamoto, Tomoyuki Uchiyama, Tomonori Yamanishi, Chiharu Yamaguchi

Published in: Clinical Autonomic Research | Issue 4/2013

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Abstract

Objective

To explore imidafenacin’s effects on bladder and cognitive function in neurologic overactive bladder (OAB) patients.

Methods

Sixty-two subjects (25 men, 37 women; mean age 70 years (25–86) with OAB due to neurologic diseases) were enrolled in the study. We conducted a urinary symptom survey and cognitive tests (MMSE, FAB, ADAS-cog) in all patients. We performed urodynamics in 35 patients and measured real-time near-infrared spectroscopy (NIRS)-urodynamics in eight patients before and after the administration of imidafenacin, an anticholinergic agent, for 3 months at 0.2 mg/day.

Results

Imidafenacin significantly ameliorated urinary urgency, nighttime urinary frequency, and quality of life index (p < 0.05). Three cognitive measures did not change significantly. Urodynamics showed increased bladder capacity (p < 0.05) but detrusor overactivity did not change significantly. NIRS showed that the subtraction of oxyhemoglobin between the start of filling and the first sensation increased in the bilateral prefrontal area but without statistical significance.

Conclusions

Imidafenacin ameliorated bladder sensation without cognitive worsening, with a trend of prefrontal activation. Regarding cognitive function, imidafenacin is safely used in OAB patients due to neurologic diseases.

Synopsis

In order to explore imidafenacin (anticholinergic agent)’s effects on bladder and brain function, we performed urinary questionnaire, cognitive tests, urodynamics and near-infrared spectroscopy (selected cases) in 62 overactive bladder (OAB) patients due to various neurologic diseases. As a result, imidafenacin ameliorated bladder sensation without cognitive worsening, with a trend of prefrontal activation. Imidafenacin seems safe in treating OAB patients due to neurologic diseases.
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Metadata
Title
Imidafenacin on bladder and cognitive function in neurologic OAB patients
Authors
Ryuji Sakakibara
Fuyuki Tateno
Masashi Yano
Osamu Takahashi
Megumi Sugiyama
Takeshi Ogata
Hiroyuki Haruta
Masahiko Kishi
Yohei Tsuyusaki
Tatsuya Yamamoto
Tomoyuki Uchiyama
Tomonori Yamanishi
Chiharu Yamaguchi
Publication date
01-08-2013
Publisher
Springer Berlin Heidelberg
Published in
Clinical Autonomic Research / Issue 4/2013
Print ISSN: 0959-9851
Electronic ISSN: 1619-1560
DOI
https://doi.org/10.1007/s10286-013-0200-3

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