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01-08-2013 | Research Article

Autonomic changes in young smokers: acute effects of inspiratory exercise

Authors: Fernando Rodrigues, Amanda Aparecida Araujo, Cristiano Teixeira Mostarda, Janaina Ferreira, Michelle Cristina de Barros Silva, Ademir Manoel Nascimento, Fabio Santos Lira, Kátia De Angelis, Maria Cláudia Irigoyen, Bruno Rodrigues

Published in: Clinical Autonomic Research | Issue 4/2013

Abstract

Purpose

One of the most important consequences of smoking is the development of cardiovascular diseases. However, little is known about the early consequences of smoking and the acute effects of a single inspiratory muscle exercise session (IME). We evaluated the acute effects of an IME on cardiac parameters of young smokers.

Methods

Twelve nonsmokers (C) and fifteen smokers [S; 2.08 (1.0–3.2) pack-years] underwent an acute IME. We evaluated blood pressure (BP) and lactate, and we recorded RR interval for posterior analysis of heart rate variability (HRV), before and after IME.

Results

At baseline, systolic BP and HRV parameters in time and frequency domains were changed in S group in comparison with the C. Following IME, S group reduced systolic BP (−8 %), low frequency band (LF) (−21.4 %), LF/high frequency (HF) (−57 %), as well as increased RR variance (+105 %) and HF band.

Conclusions

Our findings indicate that a single session of inspiratory muscle exercise was able to both reduce systolic BP and improve parasympathetic and sympathetic modulations in young smokers. The results of the current study highlight the importance of furthering research on this area to better elucidate the acute and chronic effects of inspiratory muscle training on early cardiovascular and pulmonary changes of cigarette smoking.

World Health Organization (2011) WHO report on the global tobacco epidemic, 2011: implementing smoke-free environments (online). http://www.who.int/tobacco/global_report/2011/en/index.html

Katz A, Grosbard A (2006) Does it all go up in smoke? Cigarette smoking and tachyarrhythmia. J Cardiovasc Electrophysiol 17:937–939. doi:10.1111/j.1540-8167.2006.00573.x PubMedCrossRef

Hanna ST (2006) Nicotine effect on cardiovascular system and ion channels. J Cardiovasc Pharmacol 47:348–358. doi:10.1097/01.fjc.0000205984.13395.9e PubMed

Adamopoulos D, Van de Borne P, Argacha JF (2008) New insights into the sympathetic, endothelial and coronary effects of nicotine. Clin Exp Pharmacol Physiol 35:458–463. doi:10.1111/j.1440-1681.2008.04896.x PubMedCrossRef

Carlsson S, Midthjell K, Grill V, Nord-Trøndelagstudy (2004) Smoking is associated with an increased risk of type 2 diabetes but a decreased risk of autoimmune diabetes in adults: an 11-year follow-up of incidence of diabetes in the Nord-Trøndelag study. Diabetologia 47:1953–1956. doi:10.1007/s00125-004-1554-9 PubMedCrossRef

Foy CG, Bell RA, Farmer DF, Goff DC Jr, LE Wagenknecht (2005) Smoking and incidence of diabetes among U.S. adults: findings from the Insulin Resistance Atherosclerosis Study. Diabetes Care 28:2501–2507. doi:10.2337/diacare.28.10.2501 PubMedCrossRef

Willi C, Bodenmann P, Ghali WA, Faris PD, Cornuz J (2007) Active smoking and the risk of type 2 diabetes: a systematic review and meta-analysis. JAMA 298:2654–2664. doi:10.1001/jama.298.22.2654 PubMedCrossRef

Zhu B, Parmley WW (1995) Hemodynamic and vascular effects of active and passive smoking. Am Heart J 130:1270–1275PubMedCrossRef

Narkiewicz K, van de Borne PJ, Hausberg M, Cooley RL, Winniford MD, Davison DE, Somers VK (1998) Cigarette smoking increases sympathetic outflow in humans. Circulation 98:528–534. doi:10.1161/01.CIR.98.6.528 PubMedCrossRef

10.

Goldenberg I, Moss AJ, McNitt S, Zareba W, Daubert JP, Hall WJ, Multicenter Andrews ML, Automatic Defibrillator Implantation Trial-II Investigators (2006) Cigarette smoking and the risk of supraventricular and ventricular tachyarrhythmias in high-risk cardiac patients with implantable cardioverter defibrillators. J Cardiovasc Electrophysiol 17:931–936. doi:10.1111/j.1540-8167.2006.00526.x PubMedCrossRef

11.

Grassi G, Seravalle G, Calhoun DA, Bolla GB, Giannattasio C, Marabini M, Del Bo A, Mancia G (1994) Mechanisms responsible for sympathetic activation by cigarette smoking in humans. Circulation 90:248–253. doi:10.1161/01.CIR.90.1.248 PubMedCrossRef

12.

Masuo K, Mikami H, Ogihara T, Tuck ML (1997) Sympathetic nerve hyperactivity precedes hyperinsulinemia and blood pressure elevation in a young, nonobese Japanese population. Am J Hypertens 10:77–83PubMedCrossRef

13.

Esler M, Straznicky N, Eikelis N, Masuo K, Lambert G, Lambert E (2006) Mechanisms of sympathetic activation in obesity-related hypertension. Hypertension 48:787–796. doi:10.1161/01.HYP.0000242642.42177.49 PubMedCrossRef

14.

Gosselink R, De Vos J, van den Heuvel SP, Segers J, Decramer M, Kwakkel G (2011) Impact of inspiratory muscle training in patients with COPD: what is the evidence? Eur Respir J 37:416–425. doi:10.1183/09031936.00031810 PubMedCrossRef

15.

Ferreira JB, Plentz RD, Stein C, Casali KR, Arena R, Lago PD (2011) Inspiratory muscle training reduces blood pressure and sympathetic activity in hypertensive patients: a randomized controlled trial. Int J Cardiol. doi:10.1016/j.ijcard.2011.09.069

16.

Mello PR, Guerra GM, Borile S, Rondon MU, Alves MJ, Negrão CE, Dal Lago P, Mostarda C, Irigoyen MC, Consolim-Colombo FM (2012) Inspiratory muscle training reduces sympathetic nervous activity and improves inspiratory muscle weakness and quality of life in patients with chronic heart failure: a clinical trial. J Cardiopulm Rehabil Prev 32:255–261. doi:10.1097/HCR.0b013e31825828da PubMed

17.

Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ, Joint National Committee on Prevention Detection, Evaluation, and Treatment of High Blood Pressure, National Heart, Lung, and Blood Institute, National High Blood Pressure Education Program Coordinating Committee (2003) Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension 42:1206–1252. doi:10.1161/01.HYP.0000107251.49515.c2 PubMedCrossRef

18.

Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CP, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G, Wanger J, ATS/ERS Task Force (2005) Standardisation of spirometry. Eur Respir J 26:319–338. doi:10.1183/09031936.05.00034805 PubMedCrossRef

19.

Malliani A, Pagani M, Lombardi F, Cerutti S (1991) Cardiovascular neural regulation explored in the frequency domain. Circulation 84:482–492. doi:10.1161/01.CIR.84.2.482 PubMedCrossRef

20.

Francica JV, Heeren MV, Tubaldini M, Sartori M, Mostarda C, Araujo RC, Irigoyen MC, De Angelis K (2013) Impairment on cardiovascular and autonomic adjustments to maximal isometric exercise tests in offspring of hypertensive parents. Eur J Prev Cardiol 20(3):480–485. doi:10.1177/2047487312452502

21.

Minami J, Ishimitsu T, Matsuoka H (1999) Effects of smoking cessation on blood pressure and heart rate variability in habitual smokers. Hypertension 33:586–590. doi:10.1161/01.HYP.33.1.586 PubMedCrossRef

22.

Somers VK, Mark AL, Abboud FM (1998) Potentiation of sympathetic nerve responses to hypoxia in borderline hypertensive subjects. Hypertension 11:608–612. doi:10.1161/01.HYP.11.6.608 CrossRef

23.

Grossman E, Grossman A, Schein MH, Zimlichman R, Gavish B (2001) Breathing-control lowers blood pressure. J Hum Hypertens 15:263–269PubMedCrossRef

24.

Mourya M, Mahajan AS, Singh NP, Jain AK (2009) Effect of slow- and fast-breathing exercises on autonomic functions in patients with essential hypertension. J Altern Complement Med 15:711–717. doi:10.1089/acm.2008.0609 PubMedCrossRef

25.

Bernardi L, Porta C, Gabutti A, Spicuzza L, Sleight P (2001) Modulatory effects of respiration. Auton Neurosci 90:47–56PubMedCrossRef

26.

Goso Y, Asanoi H, Ishise H, Kameyama T, Hirai T, Nozawa T, Takashima S, Umeno K, Inoue H (2001) Respiratory modulation of muscle sympathetic nerve activity in patients with chronic heart failure. Circulation 104:418–423. doi:10.1161/hc2901.093111 PubMedCrossRef

Title: Autonomic changes in young smokers: acute effects of inspiratory exercise
Authors: Fernando Rodrigues
Amanda Aparecida Araujo
Cristiano Teixeira Mostarda
Janaina Ferreira
Michelle Cristina de Barros Silva
Ademir Manoel Nascimento
Fabio Santos Lira
Kátia De Angelis
Maria Cláudia Irigoyen
Bruno Rodrigues
Publication date: 01-08-2013
Publisher: Springer Berlin Heidelberg
Published in: Clinical Autonomic Research / Issue 4/2013
Print ISSN: 0959-9851
Electronic ISSN: 1619-1560
DOI: https://doi.org/10.1007/s10286-013-0202-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Autonomic changes in young smokers: acute effects of inspiratory exercise

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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