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Basic Research in Cardiology
Published in: Basic Research in Cardiology 2/2008

01-03-2008 | REVIEW

Imaging of the heart with computed tomography

Authors: Thomas G. Flohr, Bernd M. Ohnesorge

Published in: Basic Research in Cardiology | Issue 2/2008

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Abstract

Imaging of the heart with computed tomography (CT) was already introduced in the 1980Îs and has meanwhile entered clinical routine as a consequence of the rapid evolution of CT technology during the last decade. In this review article, we give an overview on the technology and clinical performance of different CT-scanner generations used for cardiac imaging, such as Electron Beam CT (EBCT), single-slice CT und multi-detector row CT (MDCT) with 4, 16 and 64 simultaneously acquired slices. We identify the limitations of current CT-scanners, indicate potential of improvement and discuss alternative system concepts such as CT with area detectors and dual source CT (DSCT).
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Literature
1.
Achenbach S, Moshage W, Ropers D, Bachmann K (1998) Curved multiplanar reconstructions for the evaluation of contrast-enhanced electron-beam CT of the coronary arteries. AJR 170:895–899PubMed
2.
Achenbach S, Ulzheimer S, Baum U et al (2000) Noninvasive coronary angiography by retrospectively ECG-gated multi-slice spiral CT. Circulation 102:2823–2828PubMed
3.
Achenbach S, Giesler T, Ropers D, Ulzheimer S, Derlien H, Schulte C, Wenkel E, Moshage W, Bautz W, Daniel WG, Kalender WA, Baum U (2001) Contrast-enhanced, retrospectively electrocardiographically-gated, multislice spiral computed tomography. Ciculation 103:2535–2538
4.
Achenbach S, Ropers D, Pohle F-K, Raaz D, von Erffa J, Yilmaz A, Muschiol G, Daniel WG (2005) Detection of coronary artery stenoses using multi-detector CT with 16 × 0,75 collimation and 375 ms rotation. Eur Heart J 26:1978–1986PubMedCrossRef
5.
Achenbach S, Ropers D, Kuettner A, Flohr T, Ohnesorge B, Bruder H, Theessen H, Karakaya M, Daniel WG, Bautz W, Kalender WA, Anders K (2006) Contrast-enhanced coronary artery visualization by dual-source computed tomography-initial experience. Eur J Radiol 57(3):331–335PubMedCrossRef
6.
Albert TSE, Kim R, Judd RM (2006) Assessment of no-reflow regions using cardiac MRI. Basic Res Cardiol 101:383–390PubMedCrossRef
7.
Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M, Detrano R (1990) Quantification of coronary artery calcium using ultrafast computed tomography. JACC 15:827–832PubMed
8.
Bahner M, Boese J, Lutz A et al (1999) Retrospectively ECG-gated spiral CT of the heart and lung. Eur Radiol 9:106–109
9.
Becker C, Knez A, Jakobs T et al (1999) Detection and quantification of coronaryartery calcification with electron-beam and conventional CT. Eur Radiol 9:620–624PubMedCrossRef
10.
Becker C, Knez A, Ohnesorge B, Schöpf U, Reiser M (2000) Imaging of non calcified coronary plaques using helical CT with retrospective EKG gating. AJR 175:423–424PubMed
11.
Becker CR, Kleffel T, Crispin A, Knez A, Young Y, Schöpf UJ, Haberl R, Reiser MF (2001) Coronary artery calcium measurement: agreement of multirow detector and electron beam CT. Am J Roentgenol 176:1295–1298
12.
Becker CR, Knez A, Leber A, Treede H, Ohnesorge B, Schoepf UJ, Reiser MF (2002) Detection of coronary artery stenoses with multislice helical CT angiography. JCAT 26(5):750–755
13.
Budoff M, Georgiou D, Brody A et al (1996) Ultrafast computed tomography as a diagnostic modality in the detection of coronary artery disease: a multicenter study. Circulation 93:898–904PubMed
14.
Cademartiri F, Mollet NR, Runza G, Baks T, Midiro M, McFadden EP, Flohr TG, Ohnesorge B, de Feyter PJ, Krestin GP (2006) Improving diagnostic accuracy of MDCT coronary angiography in patients with mild heart rhythm irregularities using ECG editing. AJR 186:634–638PubMedCrossRef
15.
Coles DR, Wilde P, Oberhoff M, Rogers CA, Karsch KR, Baumbach A (2006) Multislice computed tomography coronary angiography in patients admitted with a suspected cute coronary syndrome. Int J Cardiovasc Imaging 23(5):603–614PubMedCrossRef
16.
Dewey M, Laule M, Krug L et al (2004) Multisegment and halfscan reconstruction of 16-slice computed tomography for detection of coronary artery stenoses. Invest Radiol 39:223–229PubMedCrossRef
17.
Dewey M, Telge F, Schnapauff D, Laule M, Borges AC, Wernecke K-D, Schink T, Baumann G, Rutsch W, Rogalla P, Taupitz M, Hamm B (2006) Noninvasive detection of coronary artery stenoses with multislice computed tomography or magnetic resonance imaging. Ann Intern Med 145:407–415PubMed
18.
Dorgelo J, Willems TP, Geluk CA, van Ooijen PMA, Zijlstra F, Oudkerk M (2005) Multidetector computed tomography guided treatment strategy in patients with non-ST elevation acute coronary syndromes: a pilot study. Eur Radiol 15:708–713PubMedCrossRef
19.
Endo M, Mori S, Kandatsu S, Tanada S, Sugihara N, Saito Y, Adachia A, Miyazaki H (2005) Development of real 4D CT with real-time reconstruction and display. IEEE Nucl Sci Symp Conf Rec 5:2603–2606CrossRef
20.
Flamm SD (1998) Coronary artery calcium screening: ready for prime time? Radiology 208:571–572PubMed
21.
Flohr T, Bruder H, Stierstorfer K, Simon J, Schaller S, Ohnesorge B (2002) New technical developments in multislice CT, Part 2: sub-millimeter 16-slice scanning and increased gantry rotation speed for cardiac imaging. Röfo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 174:1022–1027PubMedCrossRef
22.
Flohr T, Schoepf UJ, Kuettner A, Halliburton S, Bruder H, Suess C, Schmidt B, Hofmann L, Yucel EK, Schaller S, Ohnesorge B (2003) Advances in Cardiac Imaging with 16-section CT-Systems. Acad Radiol 10:386–401PubMedCrossRef
23.
Flohr T, Ohnesorge B, Bruder H, Stierstorfer K, Simon J, Suess C, Schaller S (2003) Image reconstruction and performance evaluation for ecg-gated spiral scanning with a 16-slice CT system. Med Phys 30(10):2650–2662PubMedCrossRef
24.
Flohr T, Stierstorfer K, Raupach R, Ulzheimer S, Bruder H (2004) Performance evaluation of a 64-Slice CT-system with z-flying focal spot. Röfo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 176:1803–1810PubMedCrossRef
25.
Flohr TG, Stierstorfer K, Ulzheimer S, Bruder H, Primak AN, McCollough CH (2005) Image reconstruction and image quality evaluation for a 64-slice CT scanner with z-flying focal spot. Med Phys 32(8):2536–2547PubMedCrossRef
26.
Flohr TG, McCollough CH, Bruder H, Petersilka M, Gruber K, Süß C, Grasruck M, Stierstorfer K, Krauss B, Raupach R, Primak AN, Küttner A, Achenbach S, Becker C, Kopp A, Ohnesorge BM (2006) First performance evaluation of a dual-source CT (DSCT) system. Eur Radiol 16(2):256–268PubMedCrossRef
27.
Gerber BL, Coche E, Pasquet A, Ketelslegers E, Vancraeynest D, Grandin C, van Beers BE, Vanoverschelde J-LJ (2005) Coronary artery stenosis: direct comparison of four-section multi-detector row CT and 3D Navigator MR imaging for detection-initial results. Radiology 234:98–108PubMedCrossRef
28.
Ghostine S, Caussin C, Daoud B, Habis M, Perrier E, Pesenti-Rossi D, Sigal-Cinqualbre A, Angel C-Y, Lancelin B, Capderou A, Paul J-F (2006) Non-invasove detection of coronary artery disease in patients with left bundle branch block using 64-slice computed tomography. JACC 48(10):1929–1934PubMed
29.
Halliburton SS, Stillman AE, Flohr T, Ohnesorge B, Obuchowski N, Lieber M, Karim W, Kuzmiak S, Kasper JM, White RD (2003) Do segmented reconstruction algorithms for cardiac multi-slice computed tomography improve image quality? Herz 28(1):20–31PubMedCrossRef
30.
Hoffmann U, Moselewski F, Cury RC, Ferencik M, Jang I, Diaz LJ, Abbara S, Brady TJ, Achenbach S (2004) Predictive value of 16-slice multidetector spiral computed tomography to detect significant obstructive coronary artery disease in patients at high risk for coronary artery disease. Circulation 110:2638–2643PubMedCrossRef
31.
Hoffmann MHK, Shi H, Schmitz BL, Schmid FT, Lieberknecht M, Schulze R, Ludwig B, Kroschel U, Jahnke N, Haerer W, Brambs H-J, Aschoff AJ (2005) Noninvasive coronary angiography with multislice computed tomography. JAMA 293:2471–2478PubMedCrossRef
32.
Ito H, Komura N, Iwakura K, Kawano S, Okamura A, Fujii K (2006) Combination study of myocardial perfusion and left ventricular filling provides an excellent prediction of clinical outcomes in patients with reperfused myocardial infarction. Basic Res Cardiol 101:400–407PubMedCrossRef
33.
Johnson TRC, Nikolaou K, Wintersperger BJ, Leber AW, von Ziegler F, Rist C, Buhmann S, Knez A, Reiser MF, Becker CR (2006) Dual source cardiac CT imaging: initial experience. Eur Radiol 16:1409–1415PubMedCrossRef
34.
Juergens KU, Grude M, Fallenberg EM, Heindel W, Fischbach R (2002) Using ECG-gated multidetector CT to evaluate global left ventricular myocardial function in patients with coronary artery disease. Am J Roentgenol 179:1545–1550
35.
Kachelriess M, Kalender W (1998) Electrocardiogram-correlated image reconstruction from subsecond spiral computed tomography scans of the heart. Med Phys 25:2417–2431PubMedCrossRef
36.
Kachelriess M, Ulzheimer S, Kalender W (2000) ECG-correlated image reconstruction from subsecond multi-slice spiral CT scans of the heart. Med Phys 27:1881–1902PubMedCrossRef
37.
Kaul S (2006) Evaluating the ‘no reflow’ phenomenon with myocardial contrast echocardiography. Basic Res Cardiol 101:391–399PubMedCrossRef
38.
Kefer JM, Coche E, Vanoverschelde J-LJ, Gerber BL (2007) Diagnostic accuracy of 16-slice multidetector-row CT for detection of in-stent restenosis vs detection of stenosis. Eur Radiol 17:87–96PubMedCrossRef
39.
Knez A, Becker CR, Leber A, Ohnesorge B, Becker A, White C, Haberl R, Reiser MF, Steinbeck G (2001) Usefulness of multislice spiral computed tomography angiography for determination of coronary artery stenoses. AJC 88:1191–1194
40.
Kondo C, Mori S, Endo M, Kusakabe K, Suzuki N, Hattori A, Kusakabe M (2005) Real-time volumetric imaging of human heart without electrocardiographic gating by 256-detector row computed tomography: initial experience. J Comput Assist Tomogr 29(5):694–698PubMedCrossRef
41.
Kopp A, Schröder S, Küttner A et al (2001) Coronary arteries: retrospectively ECG-gated multidetector row CT angiography with selective optimization of the image reconstruction window. Radiology 221:683–688PubMedCrossRef
42.
Kopp AF, Ohnesorge B, Becker C, Schröder S, Heuschmid M, Küttner A, Kuzo R, Claussen CD (2002) Reproducibility and accuracy of coronary calcium measurement with multidetector-row versus electron beam CT. Radiology 225:113–119PubMedCrossRef
43.
Kuettner A, Trabold T, Schroeder S, Feyer A, Beck T, Brueckner A, Heuschmid M, Burgstahler C, Kopp AF, Claussen CD (2004) Noninvasive detection of coronary lesions using 16-detector multislice spiral computed tomography technology. JACC 44:1230–1237PubMed
44.
Kuettner A, Kopp AF, Schroeder S, Rieger T, Brunn J, Meisner C, Heuschmid M, Trabold T, Burgstahler C, Martensen J, Schoebel W, Selbmann H-K, Claussen CD (2004) Diagnostic accuracy of multidetector computed tomography coronary angiography in patients with angiographically proven coronary artery disease. JACC 43(5):831–839PubMed
45.
Kuettner A, Beck T, Drosch T et al (2005) Diagnostic accuracy of noninvasive coronary imaging using 16-detector slice spiral computed tomography with 188 ms temporal resolution. JACC 45:123–127PubMed
46.
Leber AW, Knez A, Becker C, Becker A, White C, Thilo C, Reiser M, Haberl R, Steinbeck G (2003) Non-invasive intravenous coronary angiography using electron beam tomography and multislice computed tomography. Heart 89:633–639PubMedCrossRef
47.
Leber AW, Knez A, von Ziegler F, Becker A, Nikolaou K, Paul S, Wintersperger B, Reiser M, Becker CR, Steinbeck G, Boekstegers P (2005) Quantification of obstructive and nonobstructive coronary lesions by 64-slice computed tomography. JACC 46(1):147–154PubMed
48.
Leschka S, Alkadhi H, Plass A, Desbiolles L, Grünenfelder J, Marincek B, Wildermuth S (2005) Accuracy of MSCT coronary angiography with 64-slice technology: first experience. Eur Heart J 26:1482–1487PubMedCrossRef
49.
Martuscelli E, Romagnoli A, D’Eliseo A, Razzini C, Tomassini M, Sperandio M, Simonetti G, Romeo F (2004) Accuracy of thin-slice computed tomography in the detection of coronary stenoses. Eur Heart J 25:1043–1048PubMedCrossRef
50.
McCollough CH, Zink FE (1994) The technical design and performance of ultrafast computed tomography. Radiol Clin North Am 32(3):521–536PubMed
51.
McCollough CH, Zink FE, Morin R (1994) Radiation dosimetry for electron beam CT. Radiology 192(3):637–643PubMed
52.
McCollough CH, Kanal KM, Lanutti N, Ryan KJ (1999) Experimental determination of section sensitivity profiles and image noise in electron beam computed tomography. Med Phys 26(2):287–295PubMedCrossRef
53.
McCollough CH, Primak AN, Saba O, Bruder H, Stierstorfer K, Raupach R, Suess C, Schmidt B, Ohnesorge BM, Flohr TG (2007) Dose performance of a 64-channel dual-source CT scanner. Radiology 243:775–784PubMedCrossRef
54.
Meijboom WB, Mollet NR, van Mieghem CA, Weustink AC, Pugliese F, van Pelt N, Cademartiri F, Vourvouri E, de Jaegere P, Krestin G P, de Feyter PJ (2007) 64-slice computed tomography coronary angiography in patients with non-ST elevation acute coronary syndrome. Heart 93(11):1386–1392PubMedCrossRef
55.
Mollet NR, Cademartiri F, Nieman K, Saia F, Lemos PA, McFadden EP, Pattynama PMT, Serruys PW, Krestin GP, de Feyter PJ (2004) Multislice spiral computed tomography coronary angiography in patients with stable angina pectoris. JACC 43(12):2265–2270PubMed
56.
Mollet NR, Cademartiri F, van Mieghem CAG, Runza G, McFadden EP, Baks T, Serruys PW, Krestin GP, de Feyter PJ (2005) High-resolution spiral computed tomography coronary angiography in patients referred for diagnostc conventional coronary angiography. Circulation 112:2318–2323PubMedCrossRef
57.
Mollet NR, Cademartiri F, Krestin GP, McFadden EP, Arampatzis CA, Serruys PW, de Feyter PJ (2005) Improved diagnostic accuracy with 16-row multislice computed tomography coronary angiography. JACC 45:128–132PubMed
58.
Morghan-Hughes GJ, Marshall AJ, Roobottom CA (2003) Multislice computed tomographic coronary angiography: experience in a UK centre. Clin Radiol 58(5):378–383CrossRef
59.
Morgan-Hughes GJ, Roobottom CA, Owens PE, Marshall AJ (2005) Highly accurate coronary angiography with submillimetre, 16-slice computed tomography. Heart 91:308–313PubMedCrossRef
60.
Mori S, Endo M, Tsunoo T, Kandatsu S, Tanada S, Aradate H et al (2004) Physical performance evaluation of a 256-slice CT-scanner for dour-dimensional imaging. Med Phys 31(6):1348–1356PubMedCrossRef
61.
Mori S, Endo M, Obata T, Tsunoo T, Susumu K, Tanada S (2006) Properties of the prototype 256-row (cone beam) CT scanner. Eur Radiol 16(9):2100–2108PubMedCrossRef
62.
Mori S, Kondo C, Suzuki N, Hattori A, Kusakabe M, Endo M (2006) Volumetric coronary angiography using the 256-detector row computed tomography scanner: comparison in vivo and in vitro with porcine models. Acta Radiol 47(2):186–191PubMedCrossRef
63.
Nieman K, Oudkerk M, Rensing BJ, van Ooijen P, Munne A, van Geuns RJ, de Feyter PJ (2001) Coronary angiography with multi-slice computed tomography. Lancet 357:599–603PubMedCrossRef
64.
Nieman K, Cademartiri F, Lemos PA, Raaijmakers R, Pattynama PMT, de Feyter PJ (2002) Reliable noninvasive coronary angiography with fast submillimeter multislice spiral computed tomography. Circulation 106:2051–2054PubMedCrossRef
65.
Nieman K, Rensing BJ, van Geuns R-JM et al (2002) Usefulness of multislice computed tomography for detecting obstructive coronary artery disease. Am J Cardiol 89:913–918PubMedCrossRef
66.
Nieman K, Rensing BJ, van Geuns R-JM, Vos J, Pattynama PMT, Krestin GP, Serruys PW, de Feyter PJ (2002) Non-invasive coronary angiography with multislice spiral computed tomography: impact of heart rate. Heart 88:470–474PubMedCrossRef
67.
Ohnesorge B, Flohr T, Becker C, Kopp A, Schoepf U, Baum U, Knez A, Klingenbeck Regn K, Reiser M (2000) Cardiac imaging by means of electro-cardiographically gated multisection spiral CT—initial experience. Radiology 217:564–571PubMed
68.
Pugliese F, Mollet NRA, Runza G, van Mieghem C, Meijboom WB, Malagutti P, Baks T, Krestin GP, de Feyter PJ, Cademartiri F (2006) Diagnostic accuracy of non-invasive 64-slice CT coronary angiography in patients with stable angina pectoris. Eur Radiol 16:575–582PubMedCrossRef
69.
Raff GL, Gallagher MJ, O’Neill WW, Goldstein JA (2005) Diagnostic accuracy of noninvasive coronary angiography using 64-slice spiral computed tomography. JACC 46(3):552–557PubMed
70.
Ritman E, Kinsey J, Robb R, Gilbert B, Harris L, Wood E (1980) Three-dimensional imaging of heart, lungs, and circulation. Science 210:273–280PubMedCrossRef
71.
Robb R, Ritman E (1979) High speed synchronous volume computed tomography of the heart. Radiology 133:655–661PubMed
72.
Ropers D, Baum U, Pohle K, Anders K, Ulzheimer S, Ohnesorge B, Schlundt C, Bautz W, Daniel WG, Achenbach S (2003) Detection of coronary artery stenoses with thin-slice multi-detector row spiral computed tomography and multiplanar reconstruction. Circulation 107:664–666PubMedCrossRef
73.
Scheffel H, Alkadhi H, Plass A, Vachenauer R, Desbiolles L, Gaemperli O, Schepis T, Frauenfelder T, Schertler T, Husmann L, Grunenfelder J, Genoni M, Kaufmann PA, Marincek B, Leschka S (2006) Accuracy of dual-source CT coronary angiography: first experience in a high pre-test probability population without heart rate control. Eur Radiol 16(12):2739–2747PubMedCrossRef
74.
Schroeder S, Kopp A, Baumbach A, Meisner C, Kuettner A, Georg C, Ohnesorge B, Herdeg C, Claussen C, Karsch K (2001) Noninvasive detection and evaluation of atherosclerotic coronary plaques with multi-slice computed tomography. JACC 37(5):1430–1435PubMed
75.
Stanford W, Rumberger J (1992) Ultrafast computed tomography in cardiac imaging: principles and practise. Futura Publishing Company, New York
76.
Taguchi K, Anno H (2000) High temporal resolution for multi-slice helical computed tomography. Med Phys 27:861–872PubMedCrossRef
77.
Vogl TJ, Abolmaali ND, Diebold T, Engelmann K, Ay M, Dogan S, Wimmer-Greinecker G, Moritz A, Herzog C (2002) Techniques for the detection of coronary atherosclerosis: multi-detector row CT coronary angiography. Radiology 223:212–220PubMedCrossRef
Metadata
Title
Imaging of the heart with computed tomography
Authors
Thomas G. Flohr
Bernd M. Ohnesorge
Publication date
01-03-2008
Publisher
D. Steinkopff-Verlag
Published in
Basic Research in Cardiology / Issue 2/2008
Print ISSN: 0300-8428
Electronic ISSN: 1435-1803
DOI
https://doi.org/10.1007/s00395-008-0699-y

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