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Published in:

01-03-2008 | REVIEW

Imaging of stem cells using MRI

Authors: Dara L. Kraitchman, VMD, PhD, Jeff W. M. Bulte, PhD

Published in: Basic Research in Cardiology | Issue 2/2008

Abstract

The administration of exogenous stem cells offers promise to regenerate many damaged organs. However, failures of these cellular therapies could be related to many issues, such as the type of stem cell, the dose of cellular therapeutic, dosing regime, and mode of delivery. The recent ability to directly label stem cells with magnetic resonance (MR) contrast agents provides a simple, straight-forward manner to monitor accurate cell delivery and track stem cells non-invasively in a serial manner. Provided here is an overview of the currently available MR-labeling methods, including direct non-specific labeling with contrast agents, indirect specific labeling with contrast agents, labeling with MRI reporter genes, and fluorine hot spot labeling. Several of these approaches have now been applied successfully in preclinical animal models of cardiovascular disease. Once properly implemented, future clinical trials may benefit greatly from imaging stem cells with MRI.

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Title: Imaging of stem cells using MRI
Authors: Dara L. Kraitchman, VMD, PhD
Jeff W. M. Bulte, PhD
Publication date: 01-03-2008
Publisher: D. Steinkopff-Verlag
Published in: Basic Research in Cardiology / Issue 2/2008
Print ISSN: 0300-8428
Electronic ISSN: 1435-1803
DOI: https://doi.org/10.1007/s00395-008-0704-5

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Imaging of stem cells using MRI

Abstract

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Abstract

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