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Journal of Imaging Informatics in Medicine

Published in:

01-02-2013

Image Analysis for Cystic Fibrosis: Computer-Assisted Airway Wall and Vessel Measurements from Low-Dose, Limited Scan Lung CT Images

Authors: Erkan Ü. Mumcuoğlu, Frederick R. Long, Robert G. Castile, Metin N. Gurcan

Published in: Journal of Imaging Informatics in Medicine | Issue 1/2013

Abstract

Cystic fibrosis (CF) is a life-limiting genetic disease that affects approximately 30,000 Americans. When compared to those of normal children, airways of infants and young children with CF have thicker walls and are more dilated in high-resolution computed tomographic (CT) imaging. In this study, we develop computer-assisted methods for assessment of airway and vessel dimensions from axial, limited scan CT lung images acquired at low pediatric radiation doses. Two methods (threshold- and model-based) were developed to automatically measure airway and vessel sizes for pairs identified by a user. These methods were evaluated on chest CT images from 16 pediatric patients (eight infants and eight children) with different stages of mild CF related lung disease. Results of threshold-based, corrected with regression analysis, and model-based approaches correlated well with both electronic caliper measurements made by experienced observers and spirometric measurements of lung function. While the model-based approach results correlated slightly better with the human measurements than those of the threshold method, a hybrid method, combining these two methods, resulted in the best results.

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Title: Image Analysis for Cystic Fibrosis: Computer-Assisted Airway Wall and Vessel Measurements from Low-Dose, Limited Scan Lung CT Images
Authors: Erkan Ü. Mumcuoğlu
Frederick R. Long
Robert G. Castile
Metin N. Gurcan
Publication date: 01-02-2013
Publisher: Springer-Verlag
Published in: Journal of Imaging Informatics in Medicine / Issue 1/2013
Print ISSN: 2948-2925
Electronic ISSN: 2948-2933
DOI: https://doi.org/10.1007/s10278-012-9476-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Image Analysis for Cystic Fibrosis: Computer-Assisted Airway Wall and Vessel Measurements from Low-Dose, Limited Scan Lung CT Images

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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