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International Journal of Hematology

Open Access 26-04-2024 | IgA Vasculitis | Original Article

Mendelian randomization reveals association of gut microbiota with Henoch–Schönlein purpura and immune thrombocytopenia

Authors: Chendong Jiang, Shu Deng, Xiaohan Ma, Juan Song, Jinpeng Li, Enwu Yuan

Published in: International Journal of Hematology

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Abstract

Gut microbiota have been linked to immune thrombocytopenia (ITP) and Henoch–Schönlein purpura (HSP) in recent studies, but a cause-and-effect relationship is unclear. We used Mendelian randomization (MR) to assess causal relationships between gut microbiota and HSP/ITP using summary statistics from the GWAS dataset of the international MiBioGen and FinnGen consortium. The IVW method was used as the main evaluation indicator. MR analysis of 196 intestinal flora and HSP/ITP/sTP phenotypes showed that 12 flora were potentially causally associated with ITP, 6 with HSP, and 9 with sTP. The genes predicted that genus Coprococcus3 (p = 0.0264, OR = 2.05, 95% CI 1.09–3.88)and genus Gordonibacter (p = 0.0073, OR = 1.38; 95% CI 1.09–1.75) were linked to a higher likelihood of developing ITP. Additionally, family Actinomycetaceae (p = 0.02, OR = 0.51, 95% CI 0.28–0.90) and order Actinomycetales (p = 0.0199, OR = 0.50, 95% CI 0.28–0.90) linked to reduced HSP risk. Genus Ruminococcaceae UCG013 (p = 0.0426, OR = 0.44, 95% CI 0.20–0.97) negatively correlated with sTP risk. Our MR analyses offer evidence of a possible cause-and-effect connection between certain gut microbiota species and the likelihood of HSP/ITP.
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Metadata
Title
Mendelian randomization reveals association of gut microbiota with Henoch–Schönlein purpura and immune thrombocytopenia
Authors
Chendong Jiang
Shu Deng
Xiaohan Ma
Juan Song
Jinpeng Li
Enwu Yuan
Publication date
26-04-2024
Publisher
Springer Nature Singapore
Published in
International Journal of Hematology
Print ISSN: 0925-5710
Electronic ISSN: 1865-3774
DOI
https://doi.org/10.1007/s12185-024-03777-1
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