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Radiation Oncology
Published in: Radiation Oncology 1/2022

Open Access 01-12-2022 | Idiopathic Pulmonary Fibrosis | Research

Outcomes of proton therapy for non-small cell lung cancer in patients with interstitial pneumonia

Authors: Shingo Hashimoto, Hiromitsu Iwata, Yukiko Hattori, Koichiro Nakajima, Kento Nomura, Kensuke Hayashi, Toshiyuki Toshito, Eiko Yamamori, Kenji Akita, Jun-etsu Mizoe, Hiroyuki Ogino, Yuta Shibamoto

Published in: Radiation Oncology | Issue 1/2022

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Abstract

Background

Interstitial pneumonia (IP) is a disease with a poor prognosis. In addition, IP patients are more likely to develop lung cancer. Since IP patients frequently develop toxicities during cancer treatment, minimally invasive cancer treatment is warranted for such patients to maintain their quality of life. This study retrospectively investigated the efficacy and safety of proton therapy (PT) for non-small cell lung cancer (NSCLC) in patients with IP.

Methods

Twenty-nine NSCLC patients with IP were treated with PT between September 2013 and December 2019. The patients had stage IA to IIIB primary NSCLC. Ten of the 29 patients exhibited the usual interstitial pneumonia pattern. The prescribed dose was 66–74 Grays (relative biological effectiveness) in 10–37 fractions.

Results

The median follow-up period was 21.1 months [interquartile range (IQR), 15.6–37.3] for all patients and 37.2 months (IQR, 24.0–49.9) for living patients. The median patient age was 77 years (IQR, 71–81). The median planning target volume was 112.0 ml (IQR, 56.1–246.3). The 2-year local control, progression-free survival, and overall survival rates were 85% (95% confidence interval: 57–95), 30% (15–47), and 45% (26–62), respectively. According to the Common Terminology Criteria for Adverse Events (version 4.0), grade 3 acute radiation pneumonitis (RP) was observed in 1 patient. Two patients developed grade 3 late RP, but no other patients experienced serious toxicities. The patients’ quality of life (European Organization for Research and Treatment of Cancer QLQ-C30 and QLQ-LC13 and SF-36) scores had not changed after 3 months.

Conclusions

PT may be a relatively safe treatment for NSCLC patients with IP, without deteriorating quality of life scores within 3 months.
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Metadata
Title
Outcomes of proton therapy for non-small cell lung cancer in patients with interstitial pneumonia
Authors
Shingo Hashimoto
Hiromitsu Iwata
Yukiko Hattori
Koichiro Nakajima
Kento Nomura
Kensuke Hayashi
Toshiyuki Toshito
Eiko Yamamori
Kenji Akita
Jun-etsu Mizoe
Hiroyuki Ogino
Yuta Shibamoto
Publication date
01-12-2022
Publisher
BioMed Central
Published in
Radiation Oncology / Issue 1/2022
Electronic ISSN: 1748-717X
DOI
https://doi.org/10.1186/s13014-022-02027-0

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