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Neuroradiology

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01-04-2016 | Diagnostic Neuroradiology

Identifying the association between contrast enhancement pattern, surgical resection, and prognosis in anaplastic glioma patients

Authors: Yinyan Wang, Kai Wang, Jiangfei Wang, Shaowu Li, Jun Ma, Jianping Dai, Tao Jiang

Published in: Neuroradiology | Issue 4/2016

Abstract

Introduction

Contrast enhancement observable on magnetic resonance (MR) images reflects the destructive features of malignant gliomas. This study aimed to investigate the relationship between radiologic patterns of tumor enhancement, extent of resection, and prognosis in patients with anaplastic gliomas (AGs).

Methods

Clinical data from 268 patients with histologically confirmed AGs were retrospectively analyzed. Contrast enhancement patterns were classified based on preoperative T1-contrast MR images. Univariate and multivariate analyses were performed to evaluate the prognostic value of MR enhancement patterns on progression-free survival (PFS) and overall survival (OS).

Results

The pattern of tumor contrast enhancement was associated with the extent of surgical resection in AGs. A gross total resection was more likely to be achieved for AGs with focal enhancement than those with diffuse (p = 0.001) or ring-like (p = 0.024) enhancement. Additionally, patients with focal-enhanced AGs had a significantly longer PFS and OS than those with diffuse (log-rank, p = 0.025 and p = 0.031, respectively) or ring-like (log-rank, p = 0.008 and p = 0.011, respectively) enhanced AGs. Furthermore, multivariate analysis identified the pattern of tumor enhancement as a significant predictor of PFS (p = 0.016, hazard ratio [HR] = 1.485) and OS (p = 0.030, HR = 1.446).

Conclusion

Our results suggested that the contrast enhancement pattern on preoperative MR images was associated with the extent of resection and predictive of survival outcomes in AG patients.

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Title: Identifying the association between contrast enhancement pattern, surgical resection, and prognosis in anaplastic glioma patients
Authors: Yinyan Wang
Kai Wang
Jiangfei Wang
Shaowu Li
Jun Ma
Jianping Dai
Tao Jiang
Publication date: 01-04-2016
Publisher: Springer Berlin Heidelberg
Published in: Neuroradiology / Issue 4/2016
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-016-1640-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Identifying the association between contrast enhancement pattern, surgical resection, and prognosis in anaplastic glioma patients

Abstract

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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