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Neuroradiology

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01-04-2016 | Diagnostic Neuroradiology

Correlation between neuromelanin-sensitive MR imaging and ¹²³I-FP-CIT SPECT in patients with parkinsonism

Authors: Keita Kuya, Yuki Shinohara, Fuminori Miyoshi, Shinya Fujii, Yoshio Tanabe, Toshihide Ogawa

Published in: Neuroradiology | Issue 4/2016

Abstract

Introduction

Neuromelanin-sensitive MR imaging (MRI) can visualize neuromelanin-containing neurons in the substantia nigra pars compacta (SNc), and its utility has been reported in the evaluation of parkinsonism. Conversely, dopamine transporter imaging by ¹²³I-N-v-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl)nortropane (FP-CIT) SPECT (DaTSCAN) is now an established method for evaluating parkinsonism, detecting presynaptic dopamine neuronal dysfunction. Both methods can assist differentiating neurodegenerative and other forms of parkinsonism. However, to our knowledge, there have been no studies concerning a correlation between the two methods. The aim of this study was to assess the utility of neuromelanin-sensitive MRI for diagnosing parkinsonism by examining a correlation with DaTSCAN.

Methods

Twenty-three patients with parkinsonism who underwent both neuromelanin-sensitive MRI and DaTSCAN were included. We measured the neuromelanin-positive SNc region volume by manually contouring the high signal intensity region of the SNc on neuromelanin-sensitive MRI and measured the specific binding ratio (SBR) on DaTSCAN. The asymmetry index of neuromelanin-positive SNc volume and the asymmetry index of SBR were also calculated.

Results

The volume of the neuromelanin-positive SNc region showed significant correlation with specific binding ratio (SBR) (right P < .001, ρ = 0.78, left P < .001, ρ = 0.86). The asymmetry index of neuromelanin-positive SNc volume also showed significant correlations with the asymmetry index of SBR (P < .001, ρ = 0.73).

Conclusions

Decrease of the high signal intensity region of the SNc on neuromelanin-sensitive MRI would indicate damage to the nigrostriatal dopaminergic function as well as loss of dopaminergic neurons. We conclude that neuromelanin-sensitive MRI is a useful diagnostic biomarker for parkinsonism.

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Title: Correlation between neuromelanin-sensitive MR imaging and 123I-FP-CIT SPECT in patients with parkinsonism
Authors: Keita Kuya
Yuki Shinohara
Fuminori Miyoshi
Shinya Fujii
Yoshio Tanabe
Toshihide Ogawa
Publication date: 01-04-2016
Publisher: Springer Berlin Heidelberg
Published in: Neuroradiology / Issue 4/2016
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-016-1644-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Correlation between neuromelanin-sensitive MR imaging and ¹²³I-FP-CIT SPECT in patients with parkinsonism

Abstract

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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