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Published in: Journal of Cancer Research and Clinical Oncology 8/2010

01-08-2010 | Original Paper

Identification of HTA as a novel-specific marker for human hepatocellular carcinoma

Authors: Yan Liu, Yuehui Li, Fengjie Guo, Miao Dai, Jiajia Wang, Jinyue Hu, Guancheng Li

Published in: Journal of Cancer Research and Clinical Oncology | Issue 8/2010

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Abstract

Background

Hepatocellular carcinoma (HCC) is the most common malignancy in the world, especially in China. Early diagnosis of new and recurrent hepatocellular carcinoma, followed by timely treatment, will help decrease mortality. Currently biomarkers are not satisfactory. Better diagnostic methods are highly demanded.

Methods

In this study, we have used in silico identification and RT-PCR test and discovered a hepatoma associated gene (HTA). Knockdown of endogenous HTA expression was performed by small interfering RNA in malignant hepatocyte HepG2. Then we tested the cell proliferative ability of these cells in vitro and in vivo.

Results

HTA was expressed specifically in some kinds of tumors, but not detected in any normal tissues. It was expressed especially high in hepatocellular carcinoma. Knockdown of endogenous HTA expression in HepG2 by small interfering RNA attenuated HCC cell growth.

Conclusions

HCA is a very good marker for tumors, especially for HCC. It could play important roles in HCC development and progression and can be a promising molecular target for the development of new diagnostic and therapeutic strategies for HCC.
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Metadata
Title
Identification of HTA as a novel-specific marker for human hepatocellular carcinoma
Authors
Yan Liu
Yuehui Li
Fengjie Guo
Miao Dai
Jiajia Wang
Jinyue Hu
Guancheng Li
Publication date
01-08-2010
Publisher
Springer-Verlag
Published in
Journal of Cancer Research and Clinical Oncology / Issue 8/2010
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI
https://doi.org/10.1007/s00432-010-0767-1

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