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01-07-2011 | Original Article

Identification of a phylogenetically distinct orthobunyavirus from group C

Authors: Cintia Lopes de Brito Magalhães, Betânia Paiva Drumond, Renata Franco Vianna Novaes, Bárbara Rezende Quinan, José Carlos de Magalhães, João Rodrigues dos Santos, Carla do Amaral Pinto, Marieta Torres de Abreu Assis, Cláudio Antônio Bonjardim, Erna Geessien Kroon, Paulo César Peregrino Ferreira

Published in: Archives of Virology | Issue 7/2011

Abstract

Apeu virus (APEUV) (family Bunyaviridae, genus Orthobunyavirus) was plaque purified and characterised by serological and molecular analysis. Neutralising assays confirmed cross-reactivity between purified APEUV clones and the Caraparu virus complex of group C orthobunyaviruses. Partial sequencing of the L, M and S segments of one APEUV clone (APEUV-CL5) was carried out. A phylogenetic tree constructed with the L amino acid sequences clustered APEUV-CL5 within the genus Orthobunyavirus, confirming its serological classification. Analysis of M segment sequences clustered APEUV-CL5 in the Caraparu virus complex (Group C), in agreement with serological tests and previous molecular characterisation. However, the sequence of the nucleocapsid gene (N) gave low identity values when compared to those of the group C viruses. The phylogenetic tree based on N nucleotide sequences clustered APEUV-CL5 next to the California and Bwamba groups. This remarkable S nucleotide variability suggests that APEUV-CL5 could be a genetic reassortant and that this evolutionary mechanism is present in the history of the group C viruses.

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Title: Identification of a phylogenetically distinct orthobunyavirus from group C
Authors: Cintia Lopes de Brito Magalhães
Betânia Paiva Drumond
Renata Franco Vianna Novaes
Bárbara Rezende Quinan
José Carlos de Magalhães
João Rodrigues dos Santos
Carla do Amaral Pinto
Marieta Torres de Abreu Assis
Cláudio Antônio Bonjardim
Erna Geessien Kroon
Paulo César Peregrino Ferreira
Publication date: 01-07-2011
Publisher: Springer Vienna
Published in: Archives of Virology / Issue 7/2011
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-011-0976-1

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