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Breast Cancer Research
Published in: Breast Cancer Research 2/2005

01-06-2005 | Poster Presentation

Hypoxia promotes invasion and metastasis of breast cancer cells by increasing lysyl oxidase expression

Authors: JT Erler, SS Jeffrey, AJ Giaccia

Published in: Breast Cancer Research | Special Issue 2/2005

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Excerpt

All solid tumors, including breast cancer, contain areas of low oxygen tension (hypoxia). Hypoxic cells are highly aggressive and metastatic, although the underlying processes remain unclear. We have found lysyl oxidase (LOX) expression to be increased by hypoxia in a variety of human cancer cell types. Lysyl oxidase (LOX) plays an essential role in the formation and maintenance of the extracellular matrix, and has previously been linked to increased in vitro invasion of breast cancer cells [1]. …
Literature
1.
Kirschmann DA, et al: A molecular role for lysyl oxidase in breast cancer invasion. Cancer Res. 2002, 62: 4478-4483.PubMed
2.
Sørlie T, et al: Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA. 2001, 98: 10869-10874. 10.1073/pnas.191367098.CrossRefPubMedPubMedCentral
3.
Zhao H, et al: Different gene expression patterns in invasive lobular and ductal carcinomas of the breast. Mol Biol Cell. 2004, 15: 2523-2536. 10.1091/mbc.E03-11-0786.CrossRefPubMedPubMedCentral
Metadata
Title
Hypoxia promotes invasion and metastasis of breast cancer cells by increasing lysyl oxidase expression
Authors
JT Erler
SS Jeffrey
AJ Giaccia
Publication date
01-06-2005
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue Special Issue 2/2005
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1186

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