Published in:
01-06-2005 | Poster Presentation
Genetic determinants of breast cancer characteristics and outcome in women under 50 years of age
Authors:
MK Schmidt, A van der Plas, SR de Kemp, S Klaver, B Nota, B Maertzdorf, R de Groot, R Udo, VTHBM Smit, A Broeks, JL Peterse, FE van Leeuwen, RAEM Tollenaar, LJ van 't Veer
Published in:
Breast Cancer Research
|
Special Issue 2/2005
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Excerpt
Germline mutations in
BRCA1 and
BRCA2 account for approximately 2–3% of breast cancers while
CHEK2*1100delC may account for an additional 0.7% [
1]. To date, several small studies have suggested a worse outcome of survival in
BRCA1 and
BRCA2 carriers. However, the evidence is inconsistent and most studies were subject to different types of bias. An increased risk for contralateral breast cancer, especially in interaction with radiotherapy, for
CHEK2*1100delC carriers has been shown [
2]. Only one study has so far evaluated the impact of
CHEK2*1100delC on survival, showing a worse disease-free survival compared with control breast cancer patients [
3]. …
