Published in:
01-08-2013 | Original Article
Hypothermia induced by adenosine 5′-monophosphate attenuates early stage injury in an acute gouty arthritis rat model
Authors:
Zhimin Miao, Weiting Guo, Shulai Lu, Wenshan Lv, Changgui Li, Yangang Wang, Shihua Zhao, Shengli Yan, Zhenyin Tao, Yunlong Wang
Published in:
Rheumatology International
|
Issue 8/2013
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Abstract
To investigate whether the hypothermia induced by Adenosine 5′-Monophosphate (5′-AMP) could attenuate early stage injury in a rat acute gouty arthritis model. Ankle joint injection with monosodium urate monohydrate crystals (MSU crystals) in hypothermia rat model which was induced by 5′-AMP and then observe whether hypothermia induced by 5′-AMP could be effectively inhibit the inflammation on acute gouty arthritis in rats. AMP-induced hypothermia has protective effects on our acute gouty arthritis, which was demonstrated by the following criteria: (1) a significant reduction in the ankle swelling (p < 0.001); (2) a significant decrease in the occurrence of leukocyte infiltration and mild hemorrhage; (3) a significant reduction in the presence of serum Interleukin-1β (IL-1β, p < 0.001) and metalloproteinase-9 (MMP-9, p < 0.001); and (4) a significant inhibition in the Nuclear Factor -κappaB (NF-κB) activity (p < 0.001). AMP-induced hypothermia could inhibit acute inflammation reaction and protect the synovial tissue against acute injury in a rat acute gouty arthritis model.