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Clinical Autonomic Research

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01-04-2021 | Hypotension | Research Article

Baroreflex function and postprandial hypotension in older adults

Authors: Kenneth M. Madden, Boris Feldman, Graydon S. Meneilly

Published in: Clinical Autonomic Research | Issue 2/2021

Abstract

Purpose

Postprandial hypotension (PPH) is a common but poorly understood etiology for fainting in older adults. One potential mechanism is age-related baroreflex dysfunction. We examined baroreflex function in older adults with PPH and without PPH (noPPH) during a standardized meal test.

Methods

57 adults (age ≥ 65; 24 PPH, 33 noPPH, mean age 77.9 ± 0.9 years, 54% female) were recruited and had meal tests performed. The baroreflex effectiveness index (BEI, %) and baroreflex sensitivity (BRS, ms/mm Hg) were calculated using the sequence method.

Results

Baseline BEI (22 ± 2 versus 23 ± 2 percent, t = − 0.411, p = 0.682) and BRS (14.1 ± 2.4 versus 13.8 ± 2.5 ms/mm of Hg, t = − 0.084, p = 0.933) were similar in PPH and noPPH subjects. During the meal test PPH subjects showed significantly lower BEI as compared to noPPH subjects (time × PPH, F = 2.791, p = 0.042), while there was no difference in the postprandial change in BRS (time, F = 0.618, p = 0.605).

Conclusion

Patients with PPH demonstrated an acute postprandial decrease in baroreflex effectiveness during meal testing as compared with normal subjects, suggesting a potential contributing mechanism for this condition.

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Title: Baroreflex function and postprandial hypotension in older adults
Authors: Kenneth M. Madden
Boris Feldman
Graydon S. Meneilly
Publication date: 01-04-2021
Publisher: Springer Berlin Heidelberg
Keywords: Hypotension
Hypotension
Published in: Clinical Autonomic Research / Issue 2/2021
Print ISSN: 0959-9851
Electronic ISSN: 1619-1560
DOI: https://doi.org/10.1007/s10286-020-00671-8

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Springer Medicine

Baroreflex function and postprandial hypotension in older adults

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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