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Indian Journal of Pediatrics
Published in: Indian Journal of Pediatrics 5/2019

01-05-2019 | Hypoglycemia | Editorial Commentary

Hypopituitarism Related Cholestatic Jaundice: Important to Recognise, Rewarding to Treat but Difficult to Diagnose!

Authors: Rishi Bolia, Anshu Srivastava

Published in: Indian Journal of Pediatrics | Issue 5/2019

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Excerpt

Congenital Hypopituitarism (CH) is defined as a deficiency of ≥2 pituitary hormones and can vary in severity and age at presentation. It has an incidence of 1–11/100,000 in the general pediatric population and may present in 1/3rd of cases as neonatal cholestasis (NC) [1, 2]. CH accounted for 1% of infants with NC in a pediatric hepatology centre in UK [1]. …
Literature
1.
Grammatikopoulos T, Deheragoda M, Strautnieks S, et al. Reduced hepatocellular expression of canalicular transport proteins in infants with neonatal cholestasis and congenital hypopituitarism. J Pediatr. 2018;200:181–7.CrossRefPubMed
2.
Ellaway CJ, Silinik M, Cowell CT, et al. Cholestatic jaundice and congenital hypopituitarism. J Paediatr Child Health. 1995;31:51–3.CrossRefPubMed
3.
4.
Spray CH, Mckiernan P, Waldron KE, Shaw N, Kirk J, Kelly DA. Investigation and outcome of neonatal hepatitis in infants with hypopituitarism. Acta Paediatr. 2000;89:951–4.CrossRefPubMed
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Alatzoglou KS, Dattani MT. Genetic forms of hypopituitarism and their manifestation in the neonatal period. Early Hum Dev. 2009;85:705–12.CrossRefPubMed
Metadata
Title
Hypopituitarism Related Cholestatic Jaundice: Important to Recognise, Rewarding to Treat but Difficult to Diagnose!
Authors
Rishi Bolia
Anshu Srivastava
Publication date
01-05-2019
Publisher
Springer India
Published in
Indian Journal of Pediatrics / Issue 5/2019
Print ISSN: 0019-5456
Electronic ISSN: 0973-7693
DOI
https://doi.org/10.1007/s12098-019-02922-7

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