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Sleep and Vigilance

13-04-2024 | Hypersomnia | Correspondence

Covid19 Vaccination as a Trigger for Hypersomnia

Authors: Abhishek Goyal, Prakhar Agarwal, Alkesh Kumar Khurana, Kirti Kadian

Published in: Sleep and Vigilance

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Abstract

Hypersomnia is characterized by an unusual increase in sleepiness, which can significantly impair functioning and negatively affect performance. Short-term sleepiness has been reported as an adverse event following immunization with COVID-19 vaccination, but persistent hypersomnia is rare. Here we report two cases of Obstructive Sleep Apnea, one on positive airway pressure treatment and other treatment naïve, who developed hypersomnia following COVID vaccination with COVISHIELD. The findings suggest that COVID-19 vaccines can trigger sleepiness and reinforces the need to take a history of recent COVID-19 vaccination in patients with unexplained Excessive daytime sleepiness.
Literature
1.
2.
Hallberg P, Smedje H, Eriksson N, Kohnke H, Daniilidou M, Öhman I, et al. Pandemrix-induced narcolepsy is associated with genes related to immunity and neuronal survival. EBioMedicine. 2019;40:595–604.CrossRefPubMedPubMedCentral
3.
Nohynek H, Jokinen J, Partinen M, Vaarala O, Kirjavainen T, Sundman J, et al. AS03 Adjuvanted AH1N1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in Finland. PLoS ONE. 2012;7(3):e33536.CrossRefPubMedPubMedCentral
4.
Wu M, Li SX, Xue P, Zhou J, Tang X. COVID-19 vaccine could trigger the relapse of secondary hypersomnia. Nat Sci Sleep. 2021;29:2267–71.CrossRef
5.
Mehra R, Heinzer R, Castillo P. Current management of residual excessive daytime sleepiness due to obstructive sleep apnea: insights for optimizing patient outcomes. Neurol Ther. 2021;10(2):651–72.CrossRefPubMedPubMedCentral
6.
Prasad N, Yadav B, Gautam S, Yadav D, Singh A. WCN23-0557 Higher pro-inflammatory cytokines are associated with anti-SARS-CoV-2 spike protein-specific seroconversion after two doses of COVAXIN™, COVISHIELD™ vaccination in renal transplant recipients. Kidney Int Rep. 2023;8(3):S395.CrossRef
7.
Vgontzas AN, Chrousos GP. Sleep, the hypothalamic-pituitary-adrenal axis, and cytokines: multiple interactions and disturbances in sleep disorders. Endocrinol Metab Clin North Am. 2002;31(1):15–36.CrossRefPubMed
8.
Garrido-Suárez BB, Garrido-Valdes M, Garrido G. Reactogenic sleepiness after COVID-19 vaccination. A hypothesis involving orexinergic system linked to inflammatory signals. Sleep Med. 2022;98:79–86.CrossRefPubMedPubMedCentral
Metadata
Title
Covid19 Vaccination as a Trigger for Hypersomnia
Authors
Abhishek Goyal
Prakhar Agarwal
Alkesh Kumar Khurana
Kirti Kadian
Publication date
13-04-2024
Publisher
Springer Nature Singapore
Published in
Sleep and Vigilance
Electronic ISSN: 2510-2265
DOI
https://doi.org/10.1007/s41782-024-00268-5