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Published in: Japanese Journal of Radiology 8/2021

01-08-2021 | Hypersensitivity Pneumonitis | Invited Review

Ground-glass opacity (GGO): a review of the differential diagnosis in the era of COVID-19

Authors: Diletta Cozzi, Edoardo Cavigli, Chiara Moroni, Olga Smorchkova, Giulia Zantonelli, Silvia Pradella, Vittorio Miele

Published in: Japanese Journal of Radiology | Issue 8/2021

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Abstract

Thoracic imaging is fundamental in the diagnostic route of Coronavirus disease 2019 (COVID-19) especially in patients admitted to hospitals. In particular, chest computed tomography (CT) has a key role in identifying the typical features of the infection. Ground-glass opacities (GGO) are one of the main CT findings, but their presence is not specific for this viral pneumonia. In fact, GGO is a radiological sign of different pathologies with both acute and subacute/chronic clinical manifestations. In the evaluation of a subject with focal or diffuse GGO, the radiologist has to know the patient’s medical history to obtain a valid diagnostic hypothesis. The authors describe the various CT appearance of GGO, related to the onset of symptoms, focusing also on the ancillary signs that can help radiologist to obtain a correct and prompt diagnosis.
Literature
1.
go back to reference Hansell DM, Bankier AA, MacMahon H, McLoud TC, Muller NL, Remy J. Fleischner society: glossary of terms for thoracic imaging. Radiology. 2008;246(3):697–722.PubMedCrossRef Hansell DM, Bankier AA, MacMahon H, McLoud TC, Muller NL, Remy J. Fleischner society: glossary of terms for thoracic imaging. Radiology. 2008;246(3):697–722.PubMedCrossRef
2.
go back to reference Hewitt MG, Miller WT, Reilly TJ, Simpson S. The relative frequencies of causes of widespread ground-glass opacity: a retrospective cohort. Eur J Radiol. 2014;83:1970–6.PubMedCrossRef Hewitt MG, Miller WT, Reilly TJ, Simpson S. The relative frequencies of causes of widespread ground-glass opacity: a retrospective cohort. Eur J Radiol. 2014;83:1970–6.PubMedCrossRef
3.
go back to reference Agostini A, Floridi C, Borgheresi A, et al. Proposal of a low-dose, long-pitch, dual-source chest CT protocol on third-generation dual source CT using a tin filter for spectral shaping at 100kVp for coronavirus disease 2019 (COVID-19) patients: a feasibility study. Radiol Med (Torino). 2020;125(4):365–73.CrossRef Agostini A, Floridi C, Borgheresi A, et al. Proposal of a low-dose, long-pitch, dual-source chest CT protocol on third-generation dual source CT using a tin filter for spectral shaping at 100kVp for coronavirus disease 2019 (COVID-19) patients: a feasibility study. Radiol Med (Torino). 2020;125(4):365–73.CrossRef
4.
go back to reference Miller WT, Shah RM. Isolated diffuse ground-glass opacity in thoracic CT: causes and clinical presentations. Am J Roentgenol. 2005;184:613–22.CrossRef Miller WT, Shah RM. Isolated diffuse ground-glass opacity in thoracic CT: causes and clinical presentations. Am J Roentgenol. 2005;184:613–22.CrossRef
5.
go back to reference Nowers K, Rasband JD, Berges G, Gosselin M. Approach to ground-glass opacification of the lung. Semin Ultrasound CT MRI. 2002;23(4):302–23.CrossRef Nowers K, Rasband JD, Berges G, Gosselin M. Approach to ground-glass opacification of the lung. Semin Ultrasound CT MRI. 2002;23(4):302–23.CrossRef
6.
go back to reference Zhou A, Wang Y, Zhu T, Xia L. CT features of coronavirus disease 2019 (COVID-19) pneumonia in 62 patients in Wuhan, China. Am J Roentgenol. 2020;214:1–8.CrossRef Zhou A, Wang Y, Zhu T, Xia L. CT features of coronavirus disease 2019 (COVID-19) pneumonia in 62 patients in Wuhan, China. Am J Roentgenol. 2020;214:1–8.CrossRef
7.
go back to reference Giovagnoni A. Facing the COVID-19 emergency: we can and we do. Radiol Med (Torino). 2020;125(4):337–8.CrossRef Giovagnoni A. Facing the COVID-19 emergency: we can and we do. Radiol Med (Torino). 2020;125(4):337–8.CrossRef
8.
go back to reference Rubin GD, Ryerson CJ, Haramati LB, et al. The role of chest imaging in patient management during the COVID-19 pandemic: a multinational consensus statement from the Fleischner society. Radiology. 2020;296:172–80.PubMedCrossRef Rubin GD, Ryerson CJ, Haramati LB, et al. The role of chest imaging in patient management during the COVID-19 pandemic: a multinational consensus statement from the Fleischner society. Radiology. 2020;296:172–80.PubMedCrossRef
13.
go back to reference Moroni C, Cozzi D, Albanesi M, et al. Chest x-ray in the emergency department during COVID-19 pandemic descending phase in Italy: correlation with patients’ outcome. Radiol Med (Torino). 2021;4:1–8. Moroni C, Cozzi D, Albanesi M, et al. Chest x-ray in the emergency department during COVID-19 pandemic descending phase in Italy: correlation with patients’ outcome. Radiol Med (Torino). 2021;4:1–8.
14.
go back to reference Borghesi A, Maroldi R. COVID-19 outbreak in Italy: experimental chest x-ray scoring system for quantifying and monitoring disease progression. Radiol Med (Torino). 2020;125(5):509–13.CrossRef Borghesi A, Maroldi R. COVID-19 outbreak in Italy: experimental chest x-ray scoring system for quantifying and monitoring disease progression. Radiol Med (Torino). 2020;125(5):509–13.CrossRef
15.
go back to reference Borghesi A, Zigliani A, Masciullo R, et al. Radiographic severity index in COVID-19 pneumonia: relationship to age and sex in 783 Italian patients. Radiol Med (Torino). 2020;125(5):461–4.CrossRef Borghesi A, Zigliani A, Masciullo R, et al. Radiographic severity index in COVID-19 pneumonia: relationship to age and sex in 783 Italian patients. Radiol Med (Torino). 2020;125(5):461–4.CrossRef
17.
go back to reference Cozzi D, Albanesi M, Cavigli E, et al. Chest x-ray in new Coronavirus disease 2019 (COVID-19) infection: findings and correlation with clinical outcome. Radiol Med (Torino). 2020;125(8):730–7.CrossRef Cozzi D, Albanesi M, Cavigli E, et al. Chest x-ray in new Coronavirus disease 2019 (COVID-19) infection: findings and correlation with clinical outcome. Radiol Med (Torino). 2020;125(8):730–7.CrossRef
18.
go back to reference Neri E, Miele V, Coppola F, Grassi R. Use of CT and artificial intelligence in suspected or COVID-19 positive patients: statement of the Italian society of medical and interventional radiology. Radiol Med (Torino). 2020;125(5):505–8.CrossRef Neri E, Miele V, Coppola F, Grassi R. Use of CT and artificial intelligence in suspected or COVID-19 positive patients: statement of the Italian society of medical and interventional radiology. Radiol Med (Torino). 2020;125(5):505–8.CrossRef
20.
go back to reference Grassi R, Cappabianca S, Urraro F, et al. Chest CT computerized aided quantification of pneumonia lesions in COVID-19 infection: a comparison among three commercial software. Int J Environ Res Public Health. 2020;17(18):6914.PubMedCentralCrossRef Grassi R, Cappabianca S, Urraro F, et al. Chest CT computerized aided quantification of pneumonia lesions in COVID-19 infection: a comparison among three commercial software. Int J Environ Res Public Health. 2020;17(18):6914.PubMedCentralCrossRef
23.
go back to reference Carotti M, Salaffi F, Sarzi-Puttini P, et al. Chest CT features of coronavirus disease 2019 (COVID-19) pneumonia: key points for radiologists. Radiol Med (Torino). 2020;125(7):636–46.CrossRef Carotti M, Salaffi F, Sarzi-Puttini P, et al. Chest CT features of coronavirus disease 2019 (COVID-19) pneumonia: key points for radiologists. Radiol Med (Torino). 2020;125(7):636–46.CrossRef
26.
28.
go back to reference Belfiore MP, Urraro F, Grassi R, et al. Artificial intelligence to codify lung CT in Covid-19 patients. Radiol Med (Torino). 2020;125(5):500–4.CrossRef Belfiore MP, Urraro F, Grassi R, et al. Artificial intelligence to codify lung CT in Covid-19 patients. Radiol Med (Torino). 2020;125(5):500–4.CrossRef
29.
go back to reference Floridi C, Fogante M, Agostini A, et al. Radiological diagnosis of coronavirus disease 2019 (COVID-19): a practical guide. Acta Biomed. 2020;91(8):51–9.PubMedPubMedCentral Floridi C, Fogante M, Agostini A, et al. Radiological diagnosis of coronavirus disease 2019 (COVID-19): a practical guide. Acta Biomed. 2020;91(8):51–9.PubMedPubMedCentral
31.
go back to reference Cheng Z, Lu Y, Cao Q, et al. Clinical features and chest CT manifestations of coronavirus disease 2019 (COVID-19) in a single-center study in Shangai, China. Am J Roentgenol. 2020;215:1–6.CrossRef Cheng Z, Lu Y, Cao Q, et al. Clinical features and chest CT manifestations of coronavirus disease 2019 (COVID-19) in a single-center study in Shangai, China. Am J Roentgenol. 2020;215:1–6.CrossRef
32.
go back to reference Giannitto C, Sposta FM, Repici A, et al. Chest CT in patients with a moderate or high pretest probability of COVID-19 and negative swab. Radiol Med (Torino). 2020;125(12):1260–70.CrossRef Giannitto C, Sposta FM, Repici A, et al. Chest CT in patients with a moderate or high pretest probability of COVID-19 and negative swab. Radiol Med (Torino). 2020;125(12):1260–70.CrossRef
33.
go back to reference Ierardi AM, Gaibazzi N, Tuttolomondo D, et al. Deep vein thrombosis in COVID-19 patients in general wards: prevalence and association with clinical and laboratory variables. Radiol Med (Torino). 2021;19:1–7. Ierardi AM, Gaibazzi N, Tuttolomondo D, et al. Deep vein thrombosis in COVID-19 patients in general wards: prevalence and association with clinical and laboratory variables. Radiol Med (Torino). 2021;19:1–7.
34.
go back to reference Fichera G, Stramare R, De Conti G, Motta R, Giraudo C. It’s not over until it’s over: the chameleonic behavior of COVID-19 over a six-day period. Radiol Med (Torino). 2020;125(5):514–6.CrossRef Fichera G, Stramare R, De Conti G, Motta R, Giraudo C. It’s not over until it’s over: the chameleonic behavior of COVID-19 over a six-day period. Radiol Med (Torino). 2020;125(5):514–6.CrossRef
36.
go back to reference Simpsons S, Kay FY, Abbara S, et al. Radiological society of North America expert consensus statement on reporting chest CT findings related to COVID-19: endorsed by the society of thoracic radiology, the American college of radiology, and RSNA. Radiol Cardiothorac Imaging. 2020;2(2):e200152.CrossRef Simpsons S, Kay FY, Abbara S, et al. Radiological society of North America expert consensus statement on reporting chest CT findings related to COVID-19: endorsed by the society of thoracic radiology, the American college of radiology, and RSNA. Radiol Cardiothorac Imaging. 2020;2(2):e200152.CrossRef
41.
go back to reference Leung AN, Gosselin MV, Napper CH, et al. Pulmonary infections after bone marrow transplantation: clinical and radiographic findings. Radiology. 1999;210:699–710.PubMedCrossRef Leung AN, Gosselin MV, Napper CH, et al. Pulmonary infections after bone marrow transplantation: clinical and radiographic findings. Radiology. 1999;210:699–710.PubMedCrossRef
42.
go back to reference Oikonomou A, Müller NL, Nantel S. Radiographic and high-resolution CT findings of influenza virus pneumonia in patients with hematologic malignancies. Am J Roentgenol. 2003;181(2):507–11.CrossRef Oikonomou A, Müller NL, Nantel S. Radiographic and high-resolution CT findings of influenza virus pneumonia in patients with hematologic malignancies. Am J Roentgenol. 2003;181(2):507–11.CrossRef
43.
go back to reference Ajlan AM, Quiney B, Nicolaou S, Müller NL. Swine-origin influenza A (H1N1) viral infection: radiographic and CT findings. Am J Roentgenol. 2009;193(6):1494–9.CrossRef Ajlan AM, Quiney B, Nicolaou S, Müller NL. Swine-origin influenza A (H1N1) viral infection: radiographic and CT findings. Am J Roentgenol. 2009;193(6):1494–9.CrossRef
44.
go back to reference Qureshi NR, Hien TT, Farrar J, Gleeson FV. The radiologic manifestations of H5N1 avian influenza. J Thorac Imaging. 2006;21(4):259–64.PubMedCrossRef Qureshi NR, Hien TT, Farrar J, Gleeson FV. The radiologic manifestations of H5N1 avian influenza. J Thorac Imaging. 2006;21(4):259–64.PubMedCrossRef
46.
go back to reference Miller WT Jr, Mickus TJ, Barbosa E Jr, Mullin C, Van Deerlin VM, Shiley KT. CT of viral lower respiratory tract infections in adults: comparison among viral organisms and between viral and bacterial infections. Am J Roentgenol. 2011;197(5):1088–95.CrossRef Miller WT Jr, Mickus TJ, Barbosa E Jr, Mullin C, Van Deerlin VM, Shiley KT. CT of viral lower respiratory tract infections in adults: comparison among viral organisms and between viral and bacterial infections. Am J Roentgenol. 2011;197(5):1088–95.CrossRef
48.
go back to reference Kim EA, Lee KS, Primack SL, et al. Viral pneumonias in adults: radiologic and pathologic findings. Radiographics. 2002;22:S137–49.PubMedCrossRef Kim EA, Lee KS, Primack SL, et al. Viral pneumonias in adults: radiologic and pathologic findings. Radiographics. 2002;22:S137–49.PubMedCrossRef
49.
go back to reference Vogel MN, Brodoefel H, Hierl T, Beck R, Bethge WA, Claussen CD, Horger MS. Differences and similarities of cytomegalovirus and pneumocystis pneumonia in HIV-negative immunocompromised patients—thin section CT morphology in the early phase of the disease. Br J Radiol. 2007;80(955):516–23. https://doi.org/10.1259/bjr/39696316.CrossRefPubMed Vogel MN, Brodoefel H, Hierl T, Beck R, Bethge WA, Claussen CD, Horger MS. Differences and similarities of cytomegalovirus and pneumocystis pneumonia in HIV-negative immunocompromised patients—thin section CT morphology in the early phase of the disease. Br J Radiol. 2007;80(955):516–23. https://​doi.​org/​10.​1259/​bjr/​39696316.CrossRefPubMed
51.
52.
go back to reference Feragalli B, Martini C, Sperandeo M, et al. The lung in systemic vasculitis: radiological patterns and differential diagnosis. Br J Radiol. 2016;89(1061):20150992.PubMedPubMedCentralCrossRef Feragalli B, Martini C, Sperandeo M, et al. The lung in systemic vasculitis: radiological patterns and differential diagnosis. Br J Radiol. 2016;89(1061):20150992.PubMedPubMedCentralCrossRef
53.
go back to reference Chung MP, Yi CA, Lee HY, Han J, Lee KS. Imaging of pulmonary vasculitis. Radiology. 2010;255(2):322–41.PubMedCrossRef Chung MP, Yi CA, Lee HY, Han J, Lee KS. Imaging of pulmonary vasculitis. Radiology. 2010;255(2):322–41.PubMedCrossRef
54.
go back to reference Kaewlai R, Avery LL, Asrani AV, Novelline RA. Multidetector CT of blunt thoracic trauma. Radiographics. 2008;28(6):1555–70.PubMedCrossRef Kaewlai R, Avery LL, Asrani AV, Novelline RA. Multidetector CT of blunt thoracic trauma. Radiographics. 2008;28(6):1555–70.PubMedCrossRef
55.
go back to reference Marchiori E, Zanetti G, Escuissato GL, et al. Reversed-halo sign: high-resolution CT scan findings in 79 patients. Chest. 2012;141(5):1260–6.PubMedCrossRef Marchiori E, Zanetti G, Escuissato GL, et al. Reversed-halo sign: high-resolution CT scan findings in 79 patients. Chest. 2012;141(5):1260–6.PubMedCrossRef
56.
go back to reference Storto ML, Kee ST, Golden JA, Webb WR. Hydrostatic pulmonary edema: high resolution CT findings. Am J Roentgenol. 1995;165(5):817–20.CrossRef Storto ML, Kee ST, Golden JA, Webb WR. Hydrostatic pulmonary edema: high resolution CT findings. Am J Roentgenol. 1995;165(5):817–20.CrossRef
57.
go back to reference Goodman LR, Fumagalli R, Tagliabue P, et al. Adult respiratory distress syndrome due to pulmonary and extrapulmonary causes: CT, clinical, and functional correlation. Radiology. 1999;213:545–52.PubMedCrossRef Goodman LR, Fumagalli R, Tagliabue P, et al. Adult respiratory distress syndrome due to pulmonary and extrapulmonary causes: CT, clinical, and functional correlation. Radiology. 1999;213:545–52.PubMedCrossRef
58.
go back to reference Ell SR. Neurogenic pulmonary edema. A review of the literature and a perspective. Invest Radiol. 1991;26(5):499–505.PubMedCrossRef Ell SR. Neurogenic pulmonary edema. A review of the literature and a perspective. Invest Radiol. 1991;26(5):499–505.PubMedCrossRef
59.
go back to reference Kishaba T, Tamaki H, Shimaoka Y, Fukuyama H, Yamashiro S. Staging of acute exacerbation in patients with idiopathic pulmonary fibrosis. Lung. 2014;192:141–9.PubMedCrossRef Kishaba T, Tamaki H, Shimaoka Y, Fukuyama H, Yamashiro S. Staging of acute exacerbation in patients with idiopathic pulmonary fibrosis. Lung. 2014;192:141–9.PubMedCrossRef
60.
go back to reference Ishiguro T, Kobayashi Y, Uozumi R, et al. Viral pneumonia requiring differentiation from acute and progressive diffuse interstitial lung disease. Intern Med. 2019;58(24):3509–19.PubMedPubMedCentralCrossRef Ishiguro T, Kobayashi Y, Uozumi R, et al. Viral pneumonia requiring differentiation from acute and progressive diffuse interstitial lung disease. Intern Med. 2019;58(24):3509–19.PubMedPubMedCentralCrossRef
61.
go back to reference Richeldi L. Time for prevention of idiopathic pulmonary fibrosis exacerbation. Ann Am Thorac Soc. 2015;12(2):S181–5.PubMedCrossRef Richeldi L. Time for prevention of idiopathic pulmonary fibrosis exacerbation. Ann Am Thorac Soc. 2015;12(2):S181–5.PubMedCrossRef
62.
go back to reference Romei C, Tavanti LM, Taliani A, et al. Automated computed tomography analysis in the assessment of idiopathic pulmonary fibrosis severity and progression. Eur J Radiol. 2020;124:108852.PubMedCrossRef Romei C, Tavanti LM, Taliani A, et al. Automated computed tomography analysis in the assessment of idiopathic pulmonary fibrosis severity and progression. Eur J Radiol. 2020;124:108852.PubMedCrossRef
64.
go back to reference Huie TJ, Olson Al, Cosgrove GP, et al. A detailed evaluation of acute respiratory decline in patients with fibrotic lung disease: aetiology and outcomes. Respirology. 2010;15:909–17.PubMedCrossRef Huie TJ, Olson Al, Cosgrove GP, et al. A detailed evaluation of acute respiratory decline in patients with fibrotic lung disease: aetiology and outcomes. Respirology. 2010;15:909–17.PubMedCrossRef
65.
go back to reference Kishaba T. Acute or subacute progressive interstitial pneumonia. Respir Investig. 2019;57(5):405–7.PubMedCrossRef Kishaba T. Acute or subacute progressive interstitial pneumonia. Respir Investig. 2019;57(5):405–7.PubMedCrossRef
66.
go back to reference Tomassetti S, Ryu JH, Piciucchi S, Chilosi M, Poletti V. Nonspecific interstitial pneumonia: what is the optimal approach to management? Semin Respir Crit Care Med. 2016;37(3):378–94.PubMedCrossRef Tomassetti S, Ryu JH, Piciucchi S, Chilosi M, Poletti V. Nonspecific interstitial pneumonia: what is the optimal approach to management? Semin Respir Crit Care Med. 2016;37(3):378–94.PubMedCrossRef
67.
go back to reference Hellemons ME, Moor CC, von der Thusen J, et al. Dequamative interstitial pneumonia: a systematic review of its features and outcomes. Eur Respir Rev. 2020;29(156):190181.PubMedCrossRef Hellemons ME, Moor CC, von der Thusen J, et al. Dequamative interstitial pneumonia: a systematic review of its features and outcomes. Eur Respir Rev. 2020;29(156):190181.PubMedCrossRef
68.
go back to reference Hidalgo A, Franquet T, Giménez A, et al. Smoking-related interstitial lung diseases: radiologic–pathologic correlation. Eur Radiol. 2006;16(11):2463–70.PubMedCrossRef Hidalgo A, Franquet T, Giménez A, et al. Smoking-related interstitial lung diseases: radiologic–pathologic correlation. Eur Radiol. 2006;16(11):2463–70.PubMedCrossRef
69.
go back to reference Elmokadem AH, Batouty NM, Bayoumi D, et al. Mimickers of novel coronavirus disease 2019 (COVID-2019) on chest CT: spectrum of CT and clinical feature. Insight Imaging. 2021;12:12.CrossRef Elmokadem AH, Batouty NM, Bayoumi D, et al. Mimickers of novel coronavirus disease 2019 (COVID-2019) on chest CT: spectrum of CT and clinical feature. Insight Imaging. 2021;12:12.CrossRef
70.
go back to reference Lynch DA, Travis WD, Muller NL, et al. Idiopathic interstitial pneumonia: CT features. Radiology. 2005;236(1):10–21.PubMedCrossRef Lynch DA, Travis WD, Muller NL, et al. Idiopathic interstitial pneumonia: CT features. Radiology. 2005;236(1):10–21.PubMedCrossRef
71.
go back to reference Hatabu H, Hunninghake GM, Richeldi L, Brown KK, et al. Interstitial lung abnormalities detected incidentally on CT: a position paper from the Fleischner society. Lancet Respir Med. 2020;8:726–37.PubMedPubMedCentralCrossRef Hatabu H, Hunninghake GM, Richeldi L, Brown KK, et al. Interstitial lung abnormalities detected incidentally on CT: a position paper from the Fleischner society. Lancet Respir Med. 2020;8:726–37.PubMedPubMedCentralCrossRef
72.
go back to reference Magee AL, Montner SM, Husain A, et al. Imaging of hypersensitivity pneumonitis. Radiol Clin. 2016;54(6):1033–46.CrossRef Magee AL, Montner SM, Husain A, et al. Imaging of hypersensitivity pneumonitis. Radiol Clin. 2016;54(6):1033–46.CrossRef
73.
go back to reference Raghu G, Remy-Jardin M, Ryerson CJ, et al. Diagnosis of hypersensitivity pneumonitis in adults. An official ATS/JRS/ALAT clinical practice guideline. Am J Respir Crit Care Med. 2020;202(3):e36-69.PubMedPubMedCentralCrossRef Raghu G, Remy-Jardin M, Ryerson CJ, et al. Diagnosis of hypersensitivity pneumonitis in adults. An official ATS/JRS/ALAT clinical practice guideline. Am J Respir Crit Care Med. 2020;202(3):e36-69.PubMedPubMedCentralCrossRef
75.
go back to reference Jeong YJ, Kim KI, Seo IJ, et al. Eosinophilic lung diseases: a clinical, radiologic and pathologic overview. Radiographics. 2007;27(3):617–37.PubMedCrossRef Jeong YJ, Kim KI, Seo IJ, et al. Eosinophilic lung diseases: a clinical, radiologic and pathologic overview. Radiographics. 2007;27(3):617–37.PubMedCrossRef
76.
go back to reference Zare Mehrjardi M, Kahkouee S, Pourabdollah M. Radio-pathological correlations of organizing pneumonia (OP): a pictorial review. Br J Radiol. 2017;90(1071):20160723.PubMedPubMedCentralCrossRef Zare Mehrjardi M, Kahkouee S, Pourabdollah M. Radio-pathological correlations of organizing pneumonia (OP): a pictorial review. Br J Radiol. 2017;90(1071):20160723.PubMedPubMedCentralCrossRef
77.
go back to reference Distefano G, Fanzone L, Palermo M, et al. HRCT patterns of drug-induced interstitial lung disease: a review. Diagnostics. 2020;10(4):244.PubMedCentralCrossRef Distefano G, Fanzone L, Palermo M, et al. HRCT patterns of drug-induced interstitial lung disease: a review. Diagnostics. 2020;10(4):244.PubMedCentralCrossRef
78.
go back to reference Holbert JM, Costello P, Li W, et al. CT features of pulmonary alveolar proteinosis. Am J Roentgenol. 2001;176(5):1287–94.CrossRef Holbert JM, Costello P, Li W, et al. CT features of pulmonary alveolar proteinosis. Am J Roentgenol. 2001;176(5):1287–94.CrossRef
81.
go back to reference Franquet T, Gimènez A, Roson N, et al. Aspiration diseases: findings, pitfalls and differential diagnosis. Radiographics. 2000;20:673–85.PubMedCrossRef Franquet T, Gimènez A, Roson N, et al. Aspiration diseases: findings, pitfalls and differential diagnosis. Radiographics. 2000;20:673–85.PubMedCrossRef
82.
go back to reference Betancourt S, Martinez-Jimenez S, Rossi S, et al. Lipoid pneumonia: spectrum of clinical and radiologic manifestations. Am J Roentgenol. 2010;194:103–9.CrossRef Betancourt S, Martinez-Jimenez S, Rossi S, et al. Lipoid pneumonia: spectrum of clinical and radiologic manifestations. Am J Roentgenol. 2010;194:103–9.CrossRef
83.
go back to reference Cozzi D, Moroni C, Addeo G, et al. Radiological patterns of lung involvement in inflammatory bowel disease. Gastroenterol Res Pract. 2018;5697846. Cozzi D, Moroni C, Addeo G, et al. Radiological patterns of lung involvement in inflammatory bowel disease. Gastroenterol Res Pract. 2018;5697846.
84.
go back to reference Meng Y, Liu CL, Cai Q, Shen YY, Chen SQ. Contrast analysis of the relationship between the HRCT sign and new pathologic classification in small ground glass nodule-like lung adenocarcinoma. Radiol Med. 2019;124(1):8–13.PubMedCrossRef Meng Y, Liu CL, Cai Q, Shen YY, Chen SQ. Contrast analysis of the relationship between the HRCT sign and new pathologic classification in small ground glass nodule-like lung adenocarcinoma. Radiol Med. 2019;124(1):8–13.PubMedCrossRef
85.
go back to reference Lee HY, Choi YL, Lee KS, et al. Pure ground-glass opacity neoplastic lung nodules: histopathology, imaging, and management. Am J Roentgenol. 2014;202(3):224–33.CrossRef Lee HY, Choi YL, Lee KS, et al. Pure ground-glass opacity neoplastic lung nodules: histopathology, imaging, and management. Am J Roentgenol. 2014;202(3):224–33.CrossRef
86.
go back to reference Gaikwad A, Gupta A, Hare S, et al. Primary adenocarcinoma of lung: a pictorial review of recent updates. Eur J Radiol. 2012;81(12):4146–55.PubMedCrossRef Gaikwad A, Gupta A, Hare S, et al. Primary adenocarcinoma of lung: a pictorial review of recent updates. Eur J Radiol. 2012;81(12):4146–55.PubMedCrossRef
87.
go back to reference Cozzi D, Dini C, Mungai F, Puccini B, Rigacci L, Miele V. Primary pulmonary lymphoma: imaging findings in 30 cases. Radiol Med. 2019;124(12):1262–9.PubMedCrossRef Cozzi D, Dini C, Mungai F, Puccini B, Rigacci L, Miele V. Primary pulmonary lymphoma: imaging findings in 30 cases. Radiol Med. 2019;124(12):1262–9.PubMedCrossRef
88.
go back to reference Criado E, Sanchez M, Ramìrez J, et al. Pulmonary sarcoidosis: typical and atypical manifestations at high-resolution CT with pathologic correlation. Radiographic. 2010;30:1567–86.CrossRef Criado E, Sanchez M, Ramìrez J, et al. Pulmonary sarcoidosis: typical and atypical manifestations at high-resolution CT with pathologic correlation. Radiographic. 2010;30:1567–86.CrossRef
89.
go back to reference Cozzi D, Bargagli E, Calabrò AG, Torricelli E, Giannelli F, Cavigli E, Miele V. Atypical HRCT manifestations of pulmonary sarcoidosis. Radiol Med. 2018;123(3):174–84.PubMedCrossRef Cozzi D, Bargagli E, Calabrò AG, Torricelli E, Giannelli F, Cavigli E, Miele V. Atypical HRCT manifestations of pulmonary sarcoidosis. Radiol Med. 2018;123(3):174–84.PubMedCrossRef
Metadata
Title
Ground-glass opacity (GGO): a review of the differential diagnosis in the era of COVID-19
Authors
Diletta Cozzi
Edoardo Cavigli
Chiara Moroni
Olga Smorchkova
Giulia Zantonelli
Silvia Pradella
Vittorio Miele
Publication date
01-08-2021
Publisher
Springer Singapore
Published in
Japanese Journal of Radiology / Issue 8/2021
Print ISSN: 1867-1071
Electronic ISSN: 1867-108X
DOI
https://doi.org/10.1007/s11604-021-01120-w

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