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Clinical Autonomic Research

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28-07-2023 | Hyperhidrosis | Review Article

Quality of life in individuals with primary hyperhidrosis: a systematic review and meta-analysis

Authors: Mattias A. S. Henning, Farnam Barati, Gregor B. E. Jemec

Published in: Clinical Autonomic Research | Issue 4/2023

Abstract

Purpose

Hyperhidrosis can be a debilitating disease that leads to the deterioration of well-being. In this study, the objective was to compare the health-related quality of life (HRQOL) in individuals with and without hyperhidrosis by conducting a systematic review and meta-analysis.

Methods

The Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement and the Meta-analysis Of Observational Studies in Epidemiology checklist were employed. We systematically searched Cochrane Library, Embase and PubMed. Two authors independently assessed the literature and extracted the data. The risk of bias was assessed using the Newcastle–Ottawa Scale. A random-effects model was employed. The heterogeneity was determined using I².

Results

Eleven studies met the eligibility criteria comprising 4297 and 147,604 participants with and without hyperhidrosis, respectively. The risk of bias ranged from high quality to very high risk of bias. The individuals with hyperhidrosis had a higher Dermatology Life Quality Index (mean difference 8.53; 95% confidence interval 3.47, 13.58; p = 0.0009) and a lower mental component summary of the short form-12 or -36 (mean difference −6.15; 95% confidence interval −9.00, −3.30; p < 0.0001) than the control individuals. No difference was found for the physical component summary score of the short form-12 or -36 (mean difference −0.88; 95% confidence interval −1.88, 0.12; p = 0.085). Studies using patient-reported outcomes, not included in the meta-analysis, showed similar results.

Conclusion

Individuals with hyperhidrosis experience a reduced HRQOL that is clinically meaningful and leads to perceivable deteriorations in their well-being. The evidence shows a high degree of heterogeneity, which warrants additional studies.

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Title: Quality of life in individuals with primary hyperhidrosis: a systematic review and meta-analysis
Authors: Mattias A. S. Henning
Farnam Barati
Gregor B. E. Jemec
Publication date: 28-07-2023
Publisher: Springer Berlin Heidelberg
Keyword: Hyperhidrosis
Published in: Clinical Autonomic Research / Issue 4/2023
Print ISSN: 0959-9851
Electronic ISSN: 1619-1560
DOI: https://doi.org/10.1007/s10286-023-00954-w

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Quality of life in individuals with primary hyperhidrosis: a systematic review and meta-analysis

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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