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BMC Neurology
Published in: BMC Neurology 1/2024

Open Access 01-12-2024 | Hyperglycemia | Research

Association between stress hyperglycemia ratio and prognosis in acute ischemic stroke: a systematic review and meta-analysis

Authors: Zhuoya Jiang, Kunyu Wang, Hanying Duan, Heqian Du, Su Gao, Jing Chen, Shaokuan Fang

Published in: BMC Neurology | Issue 1/2024

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Abstract

Background

Stress hyperglycemia is a relatively transient increase in blood glucose in response to inflammation of the body and neurohormonal disorders. It is still debated whether stress hyperglycemia ratio (SHR) in the acute phase, a new indicator of stress hyperglycemia, is related to poor prognosis in acute ischemic stroke (AIS) patients. This meta-analysis provides insight into the connection between SHR and prognosis in AIS patients.

Methods

We screened all potentially relevant studies using a comprehensive database search. The standardized mean difference (SMD) and 95% confidence interval (CI) were utilized to investigate the relationship between SHR in the acute phase and the prognosis of AIS.

Results

The pooled results revealed that AIS patients with poor prognoses had significantly higher SHR values than those with good prognoses (SMD = 0.56, 95%CI: 0.37–0.75, p<0.001). Subgroup analysis indicated that study design and differences in post-stroke treatment might be the sources of heterogeneity in this meta-analysis.

Conclusions

High SHR in the acute period is related to poor prognosis after AIS. SHR may be a new predictor of poor outcomes in AIS patients.
Appendix
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Metadata
Title
Association between stress hyperglycemia ratio and prognosis in acute ischemic stroke: a systematic review and meta-analysis
Authors
Zhuoya Jiang
Kunyu Wang
Hanying Duan
Heqian Du
Su Gao
Jing Chen
Shaokuan Fang
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2024
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/s12883-023-03519-6

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