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Published in: Journal of Thrombosis and Thrombolysis 4/2014

Open Access 01-11-2014

Hyperfibrinogenemia predicts long-term risk of death after ischemic stroke

Authors: Marta Swarowska, Agnieszka Polczak, Joanna Pera, Aleksandra Klimkowicz-Mrowiec, Agnieszka Slowik, Tomasz Dziedzic

Published in: Journal of Thrombosis and Thrombolysis | Issue 4/2014

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Abstract

In stroke patients higher levels of plasma fibrinogen are associated with increased risk of unfavourable functional outcome and short-term mortality. The aim of our study was to determine the relationship between plasma fibrinogen level and long-term risk of death in ischemic stroke patients. Seven hundred thirty six patients (median age 71; 47.1 % men) admitted to the stroke unit within 24 h after stroke were included. Plasma fibrinogen level was measured on day 1 of hospitalisation. Hyperfibrinogenemia was defined as plasma fibrinogen concentration >3.5 g/L. The maximal follow-up period was 84 months. Hyperfibrinogenemia was found in 25.0 % of patients. On multivariate logistic regression analysis, after adjustment for age, stroke severity, atrial fibrillation, smoking, white blood cell count, fever, in-hospital pneumonia and hyperglycemia, hyperfibrinogenemia was associated with increased case fatality (HR 1.71, 95 % CI 1.29–2.26, P < 0.01). Hyperfibrinogenemia predicts the long-term risk of death in ischemic stroke patients.
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Metadata
Title
Hyperfibrinogenemia predicts long-term risk of death after ischemic stroke
Authors
Marta Swarowska
Agnieszka Polczak
Joanna Pera
Aleksandra Klimkowicz-Mrowiec
Agnieszka Slowik
Tomasz Dziedzic
Publication date
01-11-2014
Publisher
Springer US
Published in
Journal of Thrombosis and Thrombolysis / Issue 4/2014
Print ISSN: 0929-5305
Electronic ISSN: 1573-742X
DOI
https://doi.org/10.1007/s11239-014-1122-1

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