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Medical Gas Research
Published in: Medical Gas Research 1/2013

Open Access 01-12-2013 | Review

Hypercapnia: is it protective in lung injury?

Authors: Alexander F Bautista, Ozan Akca

Published in: Medical Gas Research | Issue 1/2013

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Abstract

Hypercapnic acidosis has been regarded as a tolerated side effect of protective lung ventilation strategies. Various in vivo and ex vivo animal studies have shown beneficial effects in acute lung injury setting, but some recent work raised concerns about its anti-inflammatory properties. This mini-review article aims to expand the potential clinical spectrum of hypercapnic acidosis in critically ill patients with lung injury. Despite the proven benefits of hypercapnic acidosis, further safety studies including dose-effect, level-and-onset of anti-inflammatory effect, and safe applicability period need to be performed in various models of lung injury in animals and humans to further elucidate its protective role.
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Metadata
Title
Hypercapnia: is it protective in lung injury?
Authors
Alexander F Bautista
Ozan Akca
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Medical Gas Research / Issue 1/2013
Electronic ISSN: 2045-9912
DOI
https://doi.org/10.1186/2045-9912-3-23

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