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01-03-2022 | Hypercalcemia | Original Article

Detection of hypokalemia disorder and its relation with hypercalcemia in blood serum using LIBS technique for patients of colorectal cancer grade I and grade II

Authors: Elshaimaa M. Emara, Haiying Song, Hisham Imam, Wael M. Elwekeel, Xun Gao, Mostafa M. Mohammed, Shibing Liu

Published in: Lasers in Medical Science | Issue 2/2022

Abstract

Cancer continues to be the most dangerous disease around the world; it causes electrolyte imbalance as well as metabolic changes. There is a complicated relationship between electrolyte disorder and cancer. Cancer patients commonly pass with abnormalities in serum electrolyte levels such as hypokalemia, hyperkalemia, hyponatremia, and hypercalcemia. So, these electrolyte imbalances indicate the existence of paraneoplastic processes and help come to a more informed prognosis. Hypokalemia is defined as a serum potassium concentration below 3.5 mmol/L and it is the second common electrolyte imbalance seen in patients with malignant diseases. In this paper, the contribution of serum potassium concentration to tumor progression was studied by applying a promising and non-invasive technique called laser-induced breakdown spectroscopy (LIBS). It was found that there is a correlation between hypokalemia and the colorectal cancer problem. Also, significant serum potassium concentration differences were detected among two different stages of the same cancer and also between two groups of the same stage of a cancer held in common but one of them suffers from hypercalcemia. In addition, the optimum conditions of LIBS setup were arranged such that it will be suitable to work with serum samples on glass substrate.

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Title: Detection of hypokalemia disorder and its relation with hypercalcemia in blood serum using LIBS technique for patients of colorectal cancer grade I and grade II
Authors: Elshaimaa M. Emara
Haiying Song
Hisham Imam
Wael M. Elwekeel
Xun Gao
Mostafa M. Mohammed
Shibing Liu
Publication date: 01-03-2022
Publisher: Springer London
Keywords: Hypercalcemia
Hypokalemia
Colorectal Cancer
Colorectal Cancer
Laser
Published in: Lasers in Medical Science / Issue 2/2022
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-021-03355-5

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Detection of hypokalemia disorder and its relation with hypercalcemia in blood serum using LIBS technique for patients of colorectal cancer grade I and grade II

Abstract

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Abstract

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