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Neuroradiology

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01-10-2021 | Hydrocephalus | Functional Neuroradiology

The topology of ventricle surfaces and its application in the analysis of hydrocephalic ventricles: a proof-of-concept study

Authors: Yu Tung Lo, Sumeet Kumar, Leanne Qiaojing Tan, Christine Lock, Nicole Chwee Har Keong

Published in: Neuroradiology | Issue 10/2021

Abstract

Purpose

The cerebral ventricles deform in a non-uniform fashion in response to increased CSF volume and/or pressure in hydrocephalic syndromes. Current research is focused on volumetric analyses, while topological analysis of ventricular surfaces remains understudied. We developed a method of quantitatively modeling the curvature of ventricular surfaces to analyze changes in ventricular surfaces in normal pressure hydrocephalus (NPH) and Alzheimer's disease (AD), using the left frontal horn as an example.

Methods

Twenty-one patients with NPH were recruited from our institution, and 21 healthy controls (HC) and patients with Alzheimer’s disease (AD) were identified from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. On T1-weighted fine-cut magnetic resonance sequences, 3D Slicer was used to segment the left frontal horn. Next, the mean curvatures at a set of points on the ventricular surface were determined. The frontal horns were scaled and centered into normalized volumes, allowing for pooling across the study subjects. The frontal horn was divided into superolateral, superomedial, inferolateral, and inferomedial surfaces, and locoregional mean curvatures were analyzed. Statistical comparisons were made between NPH, AD, and HC groups.

Results

Significant differences in the mean curvature of lateral surfaces of the ventricles distinguished patterns of distortion between all three cohorts. Significant flattening of the superomedial surface discriminated NPH from HC and AD. However, significant rounding of the inferomedial surface compared to controls was a distinguishing feature of NPH alone.

Conclusion

NPH ventricles deform non-uniformly. The pattern of surface distortion may be used as an additional tool to differentiate between these hydrocephalic conditions.

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Title: The topology of ventricle surfaces and its application in the analysis of hydrocephalic ventricles: a proof-of-concept study
Authors: Yu Tung Lo
Sumeet Kumar
Leanne Qiaojing Tan
Christine Lock
Nicole Chwee Har Keong
Publication date: 01-10-2021
Publisher: Springer Berlin Heidelberg
Keywords: Hydrocephalus
Hydrocephalus
Hydrocephalus
Alzheimer's Disease
Alzheimer's Disease
Published in: Neuroradiology / Issue 10/2021
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-021-02698-8

At a glance: The STEP trials

Springer Medicine

The topology of ventricle surfaces and its application in the analysis of hydrocephalic ventricles: a proof-of-concept study

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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