Skip to main content
Top
Published in: European Journal of Nuclear Medicine and Molecular Imaging 3/2009

01-03-2009 | Editorial Commentary

Hybrid PET-dynamic CECT in the management of breast cancer

Authors: Rakesh Kumar, Chandan Jyoti Das

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 3/2009

Login to get access

Excerpt

Breast cancer is the most common cancer and second commonest cause of cancer death after lung and bronchial cancer in women. In Europe, 429,900 cases of breast cancer were diagnosed in 2006 and 131,900 women died from breast cancer in the same year [1]. It has been estimated that 182,460 new cases of breast cancer will have been diagnosed and 71,030 patients will have died from breast cancer in United States in 2008 [2]. Early diagnosis and reliable imaging assessment of response to treatment are essential in the clinical management of breast cancer. Conventional imaging modalities such as screen-film mammography, digital mammography, ultrasonography (USG), and magnetic resonance imaging (MRI), provide only morphological details and do not provide information on the metabolic status of a lesion, which is very important in differentiating a benign from a malignant lesion, and therefore conventional imaging modalities lack specificity. …
Literature
1.
go back to reference Ferlay J, Autier P, Boniol M, Heanue M, Colombet M, Boyle P. Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 2007;18:581–92.PubMedCrossRef Ferlay J, Autier P, Boniol M, Heanue M, Colombet M, Boyle P. Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 2007;18:581–92.PubMedCrossRef
2.
go back to reference Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, et al. Cancer statistics 2008 CA. Cancer J Clin 2008;58:71–96.CrossRef Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, et al. Cancer statistics 2008 CA. Cancer J Clin 2008;58:71–96.CrossRef
3.
go back to reference Cermik TF, Mavi A, Basu S, Alavi A. Impact of FDG PET on the preoperative staging of newly diagnosed breast cancer. Eur J Nucl Med Mol Imaging 2008;35:475–83.PubMedCrossRef Cermik TF, Mavi A, Basu S, Alavi A. Impact of FDG PET on the preoperative staging of newly diagnosed breast cancer. Eur J Nucl Med Mol Imaging 2008;35:475–83.PubMedCrossRef
4.
go back to reference Belohlavek O. What is the role of FDG-PET in the initial staging of breast cancer. Eur J Nucl Med Mol Imaging 2008;35:472–4.PubMedCrossRef Belohlavek O. What is the role of FDG-PET in the initial staging of breast cancer. Eur J Nucl Med Mol Imaging 2008;35:472–4.PubMedCrossRef
5.
go back to reference Basu S, Mavi A, Cermik T, Houseni M, Alavi A. Implications of standardized uptake value measurements of the primary lesions in proven cases of breast carcinoma with different degree of disease burden at diagnosis: does 2-deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography predict tumor biology? Mol Imaging Biol 2008;10:62–6.PubMedCrossRef Basu S, Mavi A, Cermik T, Houseni M, Alavi A. Implications of standardized uptake value measurements of the primary lesions in proven cases of breast carcinoma with different degree of disease burden at diagnosis: does 2-deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography predict tumor biology? Mol Imaging Biol 2008;10:62–6.PubMedCrossRef
6.
go back to reference Kumar R, Loving V, Chauhan A, Zhuang H, Alavi A. Dual time point imaging and its potential to improve breast cancer diagnosis with F18-fluorodeoxyglucose positron emission tomography. J Nucl Med 2005;46:1819–24.PubMed Kumar R, Loving V, Chauhan A, Zhuang H, Alavi A. Dual time point imaging and its potential to improve breast cancer diagnosis with F18-fluorodeoxyglucose positron emission tomography. J Nucl Med 2005;46:1819–24.PubMed
7.
go back to reference Kumar R, Chauhan A, Zhuang H, Chandra P, Schnall M, et al. Standardized uptake values of normal breast tissue with 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography: variations with age, breast density, and menopausal status. Mol Imaging Biol 2006;8:355–62.PubMedCrossRef Kumar R, Chauhan A, Zhuang H, Chandra P, Schnall M, et al. Standardized uptake values of normal breast tissue with 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography: variations with age, breast density, and menopausal status. Mol Imaging Biol 2006;8:355–62.PubMedCrossRef
8.
go back to reference Kumar R, Chauhan A, Zhuang H, Chandra P, Alavi A. Clinicopathologic factors associated with false negative FDG-PET in primary breast cancer. Breast Cancer Res Treat 2006;98:267–74.PubMedCrossRef Kumar R, Chauhan A, Zhuang H, Chandra P, Alavi A. Clinicopathologic factors associated with false negative FDG-PET in primary breast cancer. Breast Cancer Res Treat 2006;98:267–74.PubMedCrossRef
9.
go back to reference Zhang J, Wang R, Lou H, Zou Y, Zhang M. Functional computed tomographic quantification of angiogenesis in rabbit VX2 soft-tissue tumour before and after interventional therapy. J Comput Assist Tomogr 2008;32:697–705.PubMedCrossRef Zhang J, Wang R, Lou H, Zou Y, Zhang M. Functional computed tomographic quantification of angiogenesis in rabbit VX2 soft-tissue tumour before and after interventional therapy. J Comput Assist Tomogr 2008;32:697–705.PubMedCrossRef
10.
go back to reference Miles KA. Perfusion imaging with computed tomography: brain and beyond. Eur Radiol 2006;16(Suppl 7):M37–M43.PubMed Miles KA. Perfusion imaging with computed tomography: brain and beyond. Eur Radiol 2006;16(Suppl 7):M37–M43.PubMed
11.
go back to reference Akashi-Tanaka S, Shien T, Tsukagoshi S, Funabasama S, Miyagawa K, Terada K, et al. Whole-breast volume perfusion images using 256-row multislice computed tomography: visualization of lesions with ductal spread. Breast Cancer 2009;16:62–7.PubMedCrossRef Akashi-Tanaka S, Shien T, Tsukagoshi S, Funabasama S, Miyagawa K, Terada K, et al. Whole-breast volume perfusion images using 256-row multislice computed tomography: visualization of lesions with ductal spread. Breast Cancer 2009;16:62–7.PubMedCrossRef
12.
go back to reference Ma SH, Le HB, Jia BH, Wang ZX, Xiao ZW, Cheng XL, et al. Peripheral pulmonary nodules: relationship between multi-slice spiral CT perfusion imaging and tumour angiogenesis and VEGF expression. BMC Cancer 2008;8:186.PubMedCrossRef Ma SH, Le HB, Jia BH, Wang ZX, Xiao ZW, Cheng XL, et al. Peripheral pulmonary nodules: relationship between multi-slice spiral CT perfusion imaging and tumour angiogenesis and VEGF expression. BMC Cancer 2008;8:186.PubMedCrossRef
13.
go back to reference Goh V, Halligan S, Wellsted DM, Bartram CI. Can perfusion CT assessment of primary colorectal adenocarcinoma blood flow at staging predict for subsequent metastatic disease? A pilot study. Eur Radiol 2008. doi:10.1007/s00330-008-1128-1. Goh V, Halligan S, Wellsted DM, Bartram CI. Can perfusion CT assessment of primary colorectal adenocarcinoma blood flow at staging predict for subsequent metastatic disease? A pilot study. Eur Radiol 2008. doi:10.​1007/​s00330-008-1128-1.
14.
go back to reference Ippolito D, Sironi S, Pozzi M, Antolini L, Ratti L, Alberzoni C, et al. Hepatocellular carcinoma in cirrhotic liver disease: functional computed tomography with perfusion imaging in the assessment of tumour vascularization. Acad Radiol 2008;15:919–27.PubMedCrossRef Ippolito D, Sironi S, Pozzi M, Antolini L, Ratti L, Alberzoni C, et al. Hepatocellular carcinoma in cirrhotic liver disease: functional computed tomography with perfusion imaging in the assessment of tumour vascularization. Acad Radiol 2008;15:919–27.PubMedCrossRef
15.
go back to reference Zhou Z, Wu J, Han M, Liu R, Chen Z, Huang H, et al. MSCT perfusion analysis of nasopharyngeal cancer. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2008;22:150–2.PubMed Zhou Z, Wu J, Han M, Liu R, Chen Z, Huang H, et al. MSCT perfusion analysis of nasopharyngeal cancer. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2008;22:150–2.PubMed
16.
go back to reference Mankoff DA, Dunnwald LK, Gralow JR, Ellis GK, Schubert EK, Tseng J, et al. Changes in blood flow and metabolism in locally advanced breast cancer treated with neoadjuvant chemotherapy. J Nucl Med 2003;44:1806–14.PubMed Mankoff DA, Dunnwald LK, Gralow JR, Ellis GK, Schubert EK, Tseng J, et al. Changes in blood flow and metabolism in locally advanced breast cancer treated with neoadjuvant chemotherapy. J Nucl Med 2003;44:1806–14.PubMed
17.
go back to reference Mankoff DA, Dunnwald LK, Gralow JR, Ellis GK, Charlop A, Lawton TJ, et al. Blood flow and metabolism in locally advanced breast cancer: relationship to response to therapy. J Nucl Med 2002;43:500–9.PubMed Mankoff DA, Dunnwald LK, Gralow JR, Ellis GK, Charlop A, Lawton TJ, et al. Blood flow and metabolism in locally advanced breast cancer: relationship to response to therapy. J Nucl Med 2002;43:500–9.PubMed
18.
go back to reference Hentschel M, Paulus T, Mix M, Moser E, Nitzsche EU, Brink I. Analysis of blood flow and glucose metabolism in mammary carcinomas and normal breast: a H2(15)O PET and 18F-FDG PET study. Nucl Med Commun 2007;28:789–97.PubMedCrossRef Hentschel M, Paulus T, Mix M, Moser E, Nitzsche EU, Brink I. Analysis of blood flow and glucose metabolism in mammary carcinomas and normal breast: a H2(15)O PET and 18F-FDG PET study. Nucl Med Commun 2007;28:789–97.PubMedCrossRef
19.
go back to reference Groves AM, Wishart GC, Shastry M, Moyle P, Iddles S, Britton P, et al. Metabolic-flow relationships in primary breast cancer: feasibility of combined PET/dynamic contrast-enhanced CT. Eur J Nucl Med Mol Imaging 2008. doi:10.1007/s00259-008-0948-1. Groves AM, Wishart GC, Shastry M, Moyle P, Iddles S, Britton P, et al. Metabolic-flow relationships in primary breast cancer: feasibility of combined PET/dynamic contrast-enhanced CT. Eur J Nucl Med Mol Imaging 2008. doi:10.​1007/​s00259-008-0948-1.
20.
go back to reference Miles KA, Griffiths MR, Keith CJ. Blood flow-metabolic relationships are dependent on tumour size in non-small cell lung cancer: a study using quantitative contrast-enhanced computer tomography and positron emission tomography. Eur J Nucl Med Mol Imaging 2006;33:22–8.PubMedCrossRef Miles KA, Griffiths MR, Keith CJ. Blood flow-metabolic relationships are dependent on tumour size in non-small cell lung cancer: a study using quantitative contrast-enhanced computer tomography and positron emission tomography. Eur J Nucl Med Mol Imaging 2006;33:22–8.PubMedCrossRef
21.
go back to reference Bisdas S, Spicer K, Rumboldt Z. Whole-tumour perfusion CT parameters and glucose metabolism measurements in head and neck squamous cell carcinomas: a pilot study using combined positron-emission tomography/CT imaging. AJNR Am J Neuroradiol 2008;29:1376–81.PubMedCrossRef Bisdas S, Spicer K, Rumboldt Z. Whole-tumour perfusion CT parameters and glucose metabolism measurements in head and neck squamous cell carcinomas: a pilot study using combined positron-emission tomography/CT imaging. AJNR Am J Neuroradiol 2008;29:1376–81.PubMedCrossRef
22.
go back to reference Hayes C, Padhani AR, Leach MO. Assessing changes in tumour vascular function using dynamic contrast-enhanced magnetic resonance imaging. NMR Biomed 2002;15:154–63.PubMedCrossRef Hayes C, Padhani AR, Leach MO. Assessing changes in tumour vascular function using dynamic contrast-enhanced magnetic resonance imaging. NMR Biomed 2002;15:154–63.PubMedCrossRef
23.
go back to reference Semple SI, Gilbert FJ, Redpath TW, Staff RT, Ahearn TS, Welch AE, et al. The relationship between vascular and metabolic characteristics of primary breast tumours. Eur Radiol 2004;14:2038–45.PubMedCrossRef Semple SI, Gilbert FJ, Redpath TW, Staff RT, Ahearn TS, Welch AE, et al. The relationship between vascular and metabolic characteristics of primary breast tumours. Eur Radiol 2004;14:2038–45.PubMedCrossRef
24.
go back to reference Brix G, Henze M, Knopp MV, Lucht R, Doll J, Junkermann H, et al. Comparison of pharmacokinetic MRI and [18F] fluorodeoxyglucose PET in the diagnosis of breast cancer: initial experience. Eur Radiol 2001;11:2058–70.PubMedCrossRef Brix G, Henze M, Knopp MV, Lucht R, Doll J, Junkermann H, et al. Comparison of pharmacokinetic MRI and [18F] fluorodeoxyglucose PET in the diagnosis of breast cancer: initial experience. Eur Radiol 2001;11:2058–70.PubMedCrossRef
Metadata
Title
Hybrid PET-dynamic CECT in the management of breast cancer
Authors
Rakesh Kumar
Chandan Jyoti Das
Publication date
01-03-2009
Publisher
Springer-Verlag
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 3/2009
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-008-1055-z

Other articles of this Issue 3/2009

European Journal of Nuclear Medicine and Molecular Imaging 3/2009 Go to the issue