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Translational Stroke Research
Published in: Translational Stroke Research 1/2013

01-02-2013 | Original Article

Hurdles to Clear Before Clinical Translation of Ischemic Postconditioning Against Stroke

Author: Heng Zhao

Published in: Translational Stroke Research | Issue 1/2013

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Abstract

Ischemic postconditioning has been established for its protective effects against stroke in animal models. It is performed after post-stroke reperfusion and refers to a series of induced ischemia or a single brief one. This review article addresses major hurdles in clinical translation of ischemic postconditioning to stroke patients, including potential hazards, the lack of well-defined protective paradigms, and the paucity of deeply understood protective mechanisms. A hormetic model, often used in toxicology to describe a dose-dependent response to a toxic agent, is suggested to study both beneficial and detrimental effects of ischemic postconditioning. Experimental strategies are discussed, including how to define the hazards of ischemic (homologous) postconditioning and the possibility of employing non-ischemic (heterologous) postconditioning to facilitate clinical translation. This review concludes that a more detailed assessment of ischemic postconditioning and studies of a broad range of heterologous postconditioning models are warranted for future clinical translation.
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Metadata
Title
Hurdles to Clear Before Clinical Translation of Ischemic Postconditioning Against Stroke
Author
Heng Zhao
Publication date
01-02-2013
Publisher
Springer US
Published in
Translational Stroke Research / Issue 1/2013
Print ISSN: 1868-4483
Electronic ISSN: 1868-601X
DOI
https://doi.org/10.1007/s12975-012-0243-0

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