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01-02-2013 | Original Article

Poised for Success: Implementation of Sound Conditioning Strategies to Promote Endogenous Protective Responses to Stroke in Patients

Authors: BethAnn McLaughlin, Jeff M. Gidday

Published in: Translational Stroke Research | Issue 1/2013

Abstract

The following perspective represents our summary of questions, ideas, concerns, and recommendations expressed by speakers and discussants at the second Biennial Translational Preconditioning Workshop held in Miami in December 2011.

Mergenthaler P, Dirnagl U. Protective conditioning of the brain: expressway or roadblock? The Journal of Physiology. 2011;589(17):4147–55.PubMedCrossRef

Koch S, Katsnelson M, Dong C, Perez-Pinzon M. Remote ischemic limb preconditioning after subarachnoid hemorrhage. Stroke. 2011;42(5):1387–91.PubMedCrossRef

Keep M, Elmer E, Fong K, Csiszar K. Intrathecal cyclosporin prolongs survival of late-stage ALS mice. Brain Res. 2001;894:327.PubMedCrossRef

Zhang Y, Park TS, Gidday JM. Hypoxic preconditioning protects human brain endothelium from ischemic apoptosis by Akt-dependent survivin activation. Americal Journal of Physiology Heart Circulation Physiology. 2007;292(6):H2573–81.CrossRef

Behl C, Holsboer F. Oxidative stress in the pathogenesis of Alzheimer’s disease and antioxidant neuroprotection. Fortschritte Der Neurologie-Psychiatrie. 1998;66(3):113–21.PubMedCrossRef

Jensen HA, Loukogeorgakis S, Yannopoulos F, Rimpiläinen E, Petzold A, Tuominen H, et al. Remote ischemic preconditioning protects the brain against injury after hypothermic circulatory arrest/clinical perspective. Circulation. 2011;123(7):714–21.PubMedCrossRef

Lyden PD, Lees KR, Davis SM. Alteplase for acute stroke revisited: the first 10 years. The Lancet Neurology. 2006;5(9):722.CrossRef

Fisher M, for the Stroke Therapy Academic Industry Roundtable IV. Enhancing the development and approval of acute stroke therapies: stroke therapy academic industry roundtable. Stroke. 2005;36(8):1808–13.PubMedCrossRef

Lapchak P, Zhang J, Noble-Haeusslein L. RIGOR guidelines: escalating STAIR and STEPS for effective translational research. Translational Stroke Research. 2012. doi:10.1007/s12975-012-0209-2.

10.

Kitano H, Young J, Cheng J, Wang L, Hurn PD, Murphy SJ. Gender-specific response to isoflurane preconditioning in focal cerebral ischemia. Journal of Cerebral Blood Flow & Metabolism. 2007;27:1377–86.CrossRef

11.

Bickler PE, Fahlman CS. Enhanced hypoxic preconditioning by isoflurane: signaling gene expression and requirement of intracellular Ca2+ and inositol triphosphate receptors. Brain Res. 2010;1340(20434434):86–95.PubMedCrossRef

12.

Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, Bradley EW, et al. A call for transparent reporting to optimize the predictive value of preclinical research. Nature. 2012;490(7419):187–91.PubMedCrossRef

13.

Lefer DJ, Bolli R. Development of an NIH Consortium for PreclinicAl AssESsment of CARdioprotective Therapies (CAESAR): a paradigm shift in studies of infarct size limitation. Journal of Cardiovascular Pharmacology and Therapeutics. 2011;16(3–4):332–9.PubMedCrossRef

14.

Vahlhaus C, Schulz R, Post H, Rose J, Heusch G. Prevention of ischemic preconditioning only by combined inhibition of protein kinase c and protein tyrosine kinase in pigs. Journal of Molecular and Cellular Cardiology. 1998;30(2):197–209.PubMedCrossRef

15.

Hoda MN, Siddiqui S, Herberg S, Periyasamy-Thandavan S, Bhatia K, Hafez SS, et al. Remote ischemic perconditioning is effective alone and in combination with intravenous tissue-type plasminogen activator in murine model of embolic stroke. Stroke. 2012;21:2012.

16.

Nowak TS, Zhao L. Conditioning studies in focal cerebral ischemia: model selection, physiological monitoring, and other methodological issues. Springer Series in Translational Stroke Research. 2013. doi:10.1007/978-1-4419-9695-4_13.

17.

Johnston SC, Johnston SC. Ischemic preconditioning from transient ischemic attacks? Data from the Northern California TIA study. Stroke. 2004;35(11_suppl_1):2680–2.PubMedCrossRef

18.

Huang DT, Walden H, Duda D, Schulman BA. Ubiquitin-like protein activation. Oncogene. 2004;23(11):1958–71.PubMedCrossRef

19.

Meller R, Minami M, Cameron JA, Impey S, Chen D, Lan JQ, et al. CREB-mediated Bcl-2 protein expression after ischemic preconditioning. J Cereb Blood Flow Metab. 2005;25:234.PubMedCrossRef

20.

Stenzel-Poore MP, Stevens SL, Xiong Z, Lessov NS, Harrington CA, Mori M, et al. Effect of ischaemic preconditioning on genomic response to cerebral ischaemia: similarity to neuroprotective strategies in hibernation and hypoxia-tolerant states. The Lancet. 2003;362(9389):1028–37.CrossRef

21.

McLaughlin BA, Hartnett KA, Erhardt JA, Legos JJ, White RF, Barone FC, et al. Caspase 3 activation is essential for neuroprotection in ischemic preconditioning. Proceedings of the National Academy of Sciences of the United States of America. 2003;100(2):715–20.PubMedCrossRef

22.

Yellon DM, Dana A. The preconditioning phenomenon: a tool for the scientist or a clinical reality? Circ Res. 2000;87(7):543–50.PubMedCrossRef

23.

Gidday JM, B.K. McMahan, Y. Zhu. Long-lasting neuroprotection induced in mouse retina by repeated hypoxic preconditioning. Invest Ophthalmol Vis Sci 2003; (Program #2942).

24.

Kadiiska MB, Gladen BC, Baird DD, Graham LB, Parker CE, Ames BN, et al. Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning. Free Radical Biology and Medicine. 2005;38(6):711–8.PubMedCrossRef

25.

Kadiiska MB, Gladen BC, Baird DD, Germolec D, Graham LB, Parker CE, et al. Biomarkers of oxidative stress study II. Are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning? Free Radical Biology and Medicine. 2005;38(6):698–710.PubMedCrossRef

26.

Goldemund D, Mikulik R. Reperfusion therapies for acute ischemic stroke. Current Treatment Options in Neurology. 2010;12(2):155–66.PubMedCrossRef

27.

Abou-Chebl A. Intra-arterial therapy for acute ischemic stroke. Neurotherapeutics. 2011;8(3):400–13.PubMedCrossRef

28.

Furlan AJ. Clot retrieval for stroke should be restricted to clinical trials no. Stroke. 2010;41(1):194–5.PubMedCrossRef

29.

Furie KL, Kasner SE, Adams RJ, Albers GW, Bush RL, Fagan SC, et al. Guidelines for the prevention of stroke in patients with stroke or transient ischemic attack. Stroke. 2011;42(1):227–76.PubMedCrossRef

30.

Della Morte D, Abete P, Gallucci F, Scaglione A, D'Ambrosio D, Gargiulo G, et al. Transient ischemic attack before nonlacunar ischemic stroke in the elderly. Journal of Stroke and Cerebrovascular Diseases. 2008;17(5):257–62.PubMedCrossRef

31.

Dirnagl U, Simon RP, Hallenbeck JM. Ischemic tolerance and endogenous neuroprotection. Trends Neurosci. 2003;26(5):248–54.PubMedCrossRef

32.

Moncayo J, de Freitas GR, Bogousslavsky J, Altieri M, van Melle G. Do transient ischemic attacks have a neuroprotective effect? Neurology. 2000;54(11):2089–94.PubMedCrossRef

33.

McLaughlin BA, Kirshner H. Wagging the dog-moving closer to features defined by basic scientists, the protection of prodromal transient ischaemic attacks reveals itself. European Journal Of Neurology. 2008;15(8):755–6.PubMedCrossRef

34.

O'Duffy AE, Bordelon YM, McLaughlin B. Killer proteases and little strokes-how the things that do not kill you make you stronger. Journal of Cerebral Blood Flow and Metabolism. 2007;27(4):655–68.PubMed

35.

Weih M, Kallenberg K, Bergk A, Dirnagl U, Harms L, Wernecke KD, Kallenberg K, Bergk A, Dirnagl U, Harms L, Wernecke KD, et al. Attenuated stroke severity after prodromal TIA: a role for ischemic tolerance in the brain? Stroke. 1999;30(9):1851–4.PubMedCrossRef

36.

Wegener S, Gottschalk B, Jovanovic V, Knab R, Fiebach JB, Schellinger PD, et al. Transient ischemic attacks before ischemic stroke: preconditioning the human brain? A multicenter magnetic resonance imaging study. Stroke. 2004;35(3):616–21.PubMedCrossRef

37.

Kissela BM, Khoury J, Alwell K, Miller R, Ewing I, Kleindorfer D, Kissela BM, Khoury J, Alwell K, Miller R, Ewing I, Kleindorfer D, et al. Long term mortality after ischemic stroke: the effect of diabetes in the greater Cincinnati/Northern Kentucky Stroke Study (GCNKSS). Stroke. 2004;35(1):315.

38.

Meyer JS, Xu G, Thornby J, Chowdhury MH, Quach M. Is mild cognitive impairment prodromal for vascular dementia like Alzheimer’s disease? Stroke. 2002;33(8):1981–5.PubMedCrossRef

39.

Sutherland BA, Minnerup J, Balami JS, Arba F, Buchan AM, Kleinschnitz C. Neuroprotection for ischaemic stroke: translation from the bench to the bedside. International Journal of Stroke. 2012;7(5):407–18.PubMedCrossRef

40.

Gonzalez NR, Liebeskind DS. Letter by Gonzalez and Liebeskind regarding article, “Remote ischemic limb preconditioning after subarachnoid hemorrhage: a Phase Ib study of safety and feasibility”. Stroke. 2011;42(9):e553.

41.

Meng R, Asmaro K, Meng L, Liu Y, Ma C, Xi C, et al. Upper limb ischemic preconditioning prevents recurrent stroke in intracranial arterial stenosis. Neurology. 2012;79(18):1853–61.PubMedCrossRef

42.

Davies SS, Traustadóttir T, Stock AA, Ye F, Shyr Y, Harman SM, et al. Ischemia/reperfusion unveils impaired capacity of older adults to restrain oxidative insult. Free Radical Biology and Medicine. 2009;47(7):1014–8.PubMedCrossRef

43.

Zaugg M, Lucchinetti E, Uecker M, Pasch T, Schaub MC. Anaesthetics and cardiac preconditioning. Part I. Signalling and cytoprotective mechanisms. Br J Anaesth. 2003;91(4):551–65.PubMedCrossRef

44.

de Leciñana MA, Fuentes B, Masjuan J, Simal P, Díaz-Otero F, Reig G, et al. Thrombolytic therapy for acute ischemic stroke after recent transient ischemic attack. International Journal of Stroke. 2012;7(3):213–8.PubMed

45.

Veighey K, MacAllister RJ. Clinical applications of remote ischemic preconditioning. Cardiology Research and Practice. 2012;2012:9.CrossRef

46.

Thuny F, Lairez O, Roubille F, Mewton N, Rioufol G, Sportouch C, et al. Post-conditioning reduces infarct size and edema in patients with ST-segment elevation myocardial infarction. Journal of the American College of Cardiology. 2012;59(24):2175–81.PubMedCrossRef

47.

Thibault H, Piot C, Staat P, Bontemps L, Sportouch C, Rioufol G, et al. Long-term benefit of postconditioning. Circulation. 2008;117(8):1037–44.PubMedCrossRef

48.

Botker HE, Kharbanda R, Schmidt MR, Bottcher M, Kaltoft AK, Terkelsen CJ, et al. Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial. Lancet. 2010;375(20189026):727–34.PubMedCrossRef

49.

Ludman AJ, Yellon DM, Hausenloy DJ. Cardiac preconditioning for ischaemia: lost in translation. Dis Model Mech. 2010;3(1–2):35–8.PubMedCrossRef

Title: Poised for Success: Implementation of Sound Conditioning Strategies to Promote Endogenous Protective Responses to Stroke in Patients
Authors: BethAnn McLaughlin
Jeff M. Gidday
Publication date: 01-02-2013
Publisher: Springer US
Published in: Translational Stroke Research / Issue 1/2013
Print ISSN: 1868-4483
Electronic ISSN: 1868-601X
DOI: https://doi.org/10.1007/s12975-012-0240-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Poised for Success: Implementation of Sound Conditioning Strategies to Promote Endogenous Protective Responses to Stroke in Patients

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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