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Virology Journal
Published in: Virology Journal 1/2013

Open Access 01-12-2013 | Research

Human rhinoviruses and enteroviruses in influenza-like illness in Latin America

Authors: Josefina Garcia, Victoria Espejo, Martha Nelson, Merly Sovero, Manuel V Villaran, Jorge Gomez, Melvin Barrantes, Felix Sanchez, Guillermo Comach, Ana E Arango, Nicolas Aguayo, Ivette L de Rivera, Wilson Chicaiza, Mirna Jimenez, Washington Aleman, Francisco Rodriguez, Marina S Gonzales, Tadeusz J Kochel, Eric S Halsey

Published in: Virology Journal | Issue 1/2013

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Abstract

Background

Human rhinoviruses (HRVs) belong to the Picornaviridae family with high similarity to human enteroviruses (HEVs). Limited data is available from Latin America regarding the clinical presentation and strains of these viruses in respiratory disease.

Methods

We collected nasopharyngeal swabs at clinics located in eight Latin American countries from 3,375 subjects aged 25 years or younger who presented with influenza-like illness.

Results

Our subjects had a median age of 3 years and a 1.2:1.0 male:female ratio. HRV was identified in 16% and HEV was identified in 3%. HRVs accounted for a higher frequency of isolates in those of younger age, in particular children < 1 years old. HRV-C accounted for 38% of all HRVs detected. Phylogenetic analysis revealed a high proportion of recombinant strains between HRV-A/HRV-C and between HEV-A/HEV-B. In addition, both EV-D68 and EV-A71 were identified.

Conclusions

In Latin America as in other regions, HRVs and HEVs account for a substantial proportion of respiratory viruses identified in young people with ILI, a finding that provides additional support for the development of pharmaceuticals and vaccines targeting these pathogens.
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Metadata
Title
Human rhinoviruses and enteroviruses in influenza-like illness in Latin America
Authors
Josefina Garcia
Victoria Espejo
Martha Nelson
Merly Sovero
Manuel V Villaran
Jorge Gomez
Melvin Barrantes
Felix Sanchez
Guillermo Comach
Ana E Arango
Nicolas Aguayo
Ivette L de Rivera
Wilson Chicaiza
Mirna Jimenez
Washington Aleman
Francisco Rodriguez
Marina S Gonzales
Tadeusz J Kochel
Eric S Halsey
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2013
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/1743-422X-10-305

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