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Head and Neck Pathology
Published in: Head and Neck Pathology 1/2019

01-03-2019 | Human Papillomavirus | Special Issue: Colors and Textures, a Review of Oral Mucosal Entities

Non-HPV Papillary Lesions of the Oral Mucosa: Clinical and Histopathologic Features of Reactive and Neoplastic Conditions

Author: Gisele N. Mainville

Published in: Head and Neck Pathology | Issue 1/2019

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Abstract

Excluding human papillomavirus (HPV)-driven conditions, oral papillary lesions consist of a variety of reactive and neoplastic conditions and, on occasion, can herald internal malignancy or be part of a syndrome. The objectives of this paper are to review the clinical and histopathological features of the most commonly encountered non-HPV papillary conditions of the oral mucosa. These include normal anatomic structures (retrocuspid papillae, lingual tonsils), reactive lesions (hairy tongue, inflammatory papillary hyperplasia), neoplastic lesions (giant cell fibroma), lesions of unknown pathogenesis (verruciform xanthoma, spongiotic gingival hyperplasia) and others associated with syndromes (for instance Cowden syndrome) or representing paraneoplastic conditions (malignant acanthosis nigricans). Common questions regarding differential diagnosis, management, and diagnostic pitfalls are addressed, stressing the importance of clinico-pathologic correlation and collaboration.
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Metadata
Title
Non-HPV Papillary Lesions of the Oral Mucosa: Clinical and Histopathologic Features of Reactive and Neoplastic Conditions
Author
Gisele N. Mainville
Publication date
01-03-2019
Publisher
Springer US
Published in
Head and Neck Pathology / Issue 1/2019
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-019-01001-9

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