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Head and Neck Pathology
Published in: Head and Neck Pathology 1/2019

01-03-2019 | Special Issue: Colors and Textures, a Review of Oral Mucosal Entities

Frictional Keratosis, Contact Keratosis and Smokeless Tobacco Keratosis: Features of Reactive White Lesions of the Oral Mucosa

Author: Susan Müller

Published in: Head and Neck Pathology | Issue 1/2019

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Abstract

White lesions of the oral cavity are quite common and can have a variety of etiologies, both benign and malignant. Although the vast majority of publications focus on leukoplakia and other potentially malignant lesions, most oral lesions that appear white are benign. This review will focus exclusively on reactive white oral lesions. Included in the discussion are frictional keratoses, irritant contact stomatitis, and smokeless tobacco keratoses. Leukoedema and hereditary genodermatoses that may enter in the clinical differential diagnoses of frictional keratoses including white sponge nevus and hereditary benign intraepithelial dyskeratosis will be reviewed. Many products can result in contact stomatitis. Dentrifice-related stomatitis, contact reactions to amalgam and cinnamon can cause keratotic lesions. Each of these lesions have microscopic findings that can assist in patient management.
Literature
1.
Sloan P, Gale N, Hunter K, et al. Malignant surface epithelial tumours: squamous cell carcinoma. In: el-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ. WHO classification of tumours of the head and neck. 4th ed. Lyon: IARC Press; 2017.
2.
Müller S. Update from the 4th Edition of the World Health Organization of Head and Neck Tumours: Tumours of the Oral Cavity and Mobile Tongue. Head Neck Pathol. 2017;11(1):33–40.CrossRefPubMedPubMedCentral
3.
Müller S. Oral epithelial dysplasia, atypical verrucous lesions and oral potentially malignant disorders: focus on histopathology. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;125(6):591–602.CrossRefPubMed
4.
Madani FM, Kuperstein AS. Normal variations of oral anatomy and common oral soft tissue lesions: evaluation and management. Med Clin North Am. 2014;98(6):1281–98.CrossRefPubMed
5.
Pinto A, Haberland CM, Baker S. Pediatric soft tissue oral lesions. Dent Clin North Am. 2014;58(2):437–53.CrossRefPubMed
6.
Woo SB, Lin D. Morsicatio mucosae oris–a chronic oral frictional keratosis, not a leukoplakia. J Oral Maxillofac Surg. 2009;67(1):140–6.CrossRefPubMed
7.
Müller S, Pan Y, Li R, Chi AC. Changing trends in oral squamous cell carcinoma with particular reference to young patients: 1971–2006. The Emory University experience. Head Neck Pathol. 2008;2(2):60–6.CrossRefPubMedPubMedCentral
8.
Müller S. Oral lichenoid lesions: distinguishing the benign from the deadly. Mod Pathol. 2017;30(s1):54–67.CrossRef
9.
Natarajan E, Woo SB. Benign alveolar ridge keratosis (oral lichen simplex chronicus): a distinct clinicopathologic entity. J Am Acad Dermatol. 2008;58(1):151–7.CrossRefPubMed
10.
Chi AC, Lambert PR 3rd, Pan Y, Li R, Vo DT, Edwards E, Gangarosa P, Neville BW. Is alveolar ridge keratosis a true leukoplakia? A clinicopathologic comparison of 2,153 lesions. J Am Dent Assoc. 2007;138(5):641–51.CrossRefPubMed
11.
Pentenero M, Meleti M, Vescovi P, Gandolfo S. Oral proliferative verrucous leucoplakia: are there particular features for such an ambiguous entity? A systematic review. Br J Dermatol. 2014;170(5):1039–47.CrossRefPubMed
12.
Cheng YS, Gould A, Kurago Z, Fantasia J, Muller S. Diagnosis of oral lichen planus: a position paper of the American Academy of Oral and Maxillofacial Pathology. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122(3):332–54.CrossRefPubMed
13.
Woo SB, Grammer RL, Lerman MA. Keratosis of unknown significance and leukoplakia: a preliminary study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;118(6):713–24.CrossRefPubMed
14.
Jones KB, Jordan R. White lesions in the oral cavity: clinical presentation, diagnosis, and treatment. Semin Cutan Med Surg. 2015;34(4):161–70.CrossRefPubMed
15.
Martin JL. Leukoedema: an epidemiological study in white and African Americans. J Tenn Dent Assoc. 1997;77(1):18–21.PubMed
16.
Martelli H Jr, Pereira SM, Rocha TM, Nogueira dos Santos PL, Batista de Paula AM, Bonan PR. White sponge nevus: report of a three-generation family. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103(1):43–7.CrossRefPubMed
17.
Cai W, Jiang B, Yu F, Yang J, Chen Z, Liu J, Wei R, Zhao S, Wang X, Liu S. Current approaches to the diagnosis and treatment of white sponge nevus. Expert Rev Mol Med. 2015;17:e9.CrossRefPubMed
18.
Haisley-Royster CA, Allingham RR, Klintworth GK, Prose NS. Hereditary benign intraepithelial dyskeratosis: report of two cases with prominent oral lesions. J Am Acad Dermatol. 2001;45(4):634–6.CrossRefPubMed
19.
Cummings TJ, Dodd LG, Eedes CR, Klintworth GK. Hereditary benign intraepithelial dyskeratosis: an evaluation of diagnostic cytology. Arch Pathol Lab Med. 2008;132(8):1325–8.PubMed
20.
21.
Skaare A, Eide G, Herlofson B, Barkvoll P. The effect of toothpaste containing triclosan on oral mucosal desquamation. A model study. J Clin Periodontol. 1996;23(12):1100–3.CrossRefPubMed
22.
Kowitz G, Jacobson J, Meng Z, Lucatorto F. The effects of tartar-control toothpaste on the oral soft tissues. Oral Surg Oral Med Oral Pathol. 1990;70(4):529–36. Review.CrossRefPubMed
23.
24.
Macdonald JB, Tobin CA, Hurley MY. Oral leukoedema with mucosal desquamation caused by toothpaste containing sodium lauryl sulfate. Cutis. 2016;97(1):E4–5.PubMed
25.
Bhattacharyya I. Case of the month. Toothpaste-related oral lesions. Todays FDA. 2009 Oct;21(10):11–3.PubMed
26.
McParland H, Warnakulasuriya S. Oral lichenoid contact lesions to mercury and dental amalgam–a review. J Biomed Biotechnol. 2012;2012:589–569.CrossRef
27.
Suter VG, Warnakulasuriya S. The role of patch testing in the management of oral lichenoid reactions. J Oral Pathol Med. 2016;45(1):48–57.CrossRefPubMed
28.
Mravak-Stipetić M, Lončar-Brzak B, Bakale-Hodak I, Sabol I, Seiwerth S, Majstorović M, Grce M. Clinicopathologic correlation of oral lichen planus and oral lichenoid lesions: a preliminary study. Sci World J. 2014;2014:746874.CrossRef
29.
Larsson A, Warfvinge G. Immunohistochemistry of ‘tertiary lymphoid follicles’ in oral amalgam-associated lichenoid lesions. Oral Dis. 1998;4(3):187–93.CrossRefPubMed
30.
Endo H, Rees TD. Clinical features of cinnamon-induced contact stomatitis. Compend Contin Educ Dent. 2006;27(7):403–9. quiz 410, 421.PubMed
31.
Tremblay S, Avon SL. Contact allergy to cinnamon: case report. J Can Dent Assoc. 2008;74(5):445–61.PubMed
32.
Kessler HP. Oral and maxillofacial pathology case of the month. Snuff dippers keratosis or snuff pouch. Tex Dent J. 2003;120(12):1181, 1186–7.
33.
Lee PN. Epidemiological evidence relating snus to health–an updated review based on recent publications. Harm Reduct J. 2013;6:10:36.CrossRef
34.
Gupta B, Johnson NW. Systematic review and meta-analysis of association of smokeless tobacco and of betel quid without tobacco with incidence of oral cancer in South Asia and the Pacific. PLoS ONE. 2014;20(11):e113385. 9(.CrossRef
35.
Greer RO Jr. Oral manifestations of smokeless tobacco use. Otolaryngol Clin North Am. 2011;44(1):31–56.CrossRefPubMed
36.
Sheth PD, Youngberg GA. Pathologic quiz case: a 30-year-old man with a white plaque in the oral mucosa. Smokeless tobacco keratosis. Arch Pathol Lab Med. 2004;128(1):e17-8.PubMed
37.
38.
Larsson A, Axéll T, Andersson G. Reversibility of snuff dippers’ lesion in Swedish moist snuff users: a clinical and histologic follow-up study. J Oral Pathol Med. 1991;20(6):258–64.CrossRefPubMed
39.
Weitkunat R, Sanders E, Lee PN. Meta-analysis of the relation between European and American smokeless tobacco and oral cancer. BMC Public Health. 2007;7:334.CrossRefPubMedPubMedCentral
40.
Metadata
Title
Frictional Keratosis, Contact Keratosis and Smokeless Tobacco Keratosis: Features of Reactive White Lesions of the Oral Mucosa
Author
Susan Müller
Publication date
01-03-2019
Publisher
Springer US
Published in
Head and Neck Pathology / Issue 1/2019
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-018-0986-3

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