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Journal of Cancer Research and Clinical Oncology

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Open Access 01-11-2020 | Human Papillomavirus | Original Article – Cancer Research

Lysine-specific histone demethylase 1A (LSD1) in cervical cancer

Authors: Daniel Beilner, Christina Kuhn, Bernd P. Kost, Julia Jückstock, Doris Mayr, Elisa Schmoeckel, Christian Dannecker, Sven Mahner, Udo Jeschke, Helene Hildegard Heidegger

Published in: Journal of Cancer Research and Clinical Oncology | Issue 11/2020

Abstract

Purpose

Demethylation of DNA through enzymes like LSD1 showed a crucial impact on different kind of cancers. Epigenetic modifications in cervical cancer are still not fully investigated nevertheless of high interest for a therapeutic use.

Methods

Tumor samples of 250 cervical cancer patients were immunochemically stained and evaluated based on Immunoreactive Score. Results were statistically analyzed for clinical and pathological parameters.

Results

Our patient collective showed a disadvantage for 10-year survival for patients with a strong expression of LSD1 in the cytoplasm of cervical cancer cells. The results of the correlational analysis further revealed a negative correlation of LSD1 to G-protein coupled estrogen receptor (GPER).

Conclusions

Epigenetic changes through enzymes like LSD1 may also be of interest for patients with cervical cancer. A combined therapy with other proteins relayed to cervical cancer like GPER might be of interest for future investigations.

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Title: Lysine-specific histone demethylase 1A (LSD1) in cervical cancer
Authors: Daniel Beilner
Christina Kuhn
Bernd P. Kost
Julia Jückstock
Doris Mayr
Elisa Schmoeckel
Christian Dannecker
Sven Mahner
Udo Jeschke
Helene Hildegard Heidegger
Publication date: 01-11-2020
Publisher: Springer Berlin Heidelberg
Keywords: Human Papillomavirus
Cervical Cancer
Cervical Cancer
Epigenetics
Published in: Journal of Cancer Research and Clinical Oncology / Issue 11/2020
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-020-03338-z

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