Top

Published in:

Open Access 01-12-2024 | Human Immunodeficiency Virus | Research

Implementation of REDCap mobile app in an oral HIV clinical study

Authors: Ana Lucia Seminario, Ashley E. Karczewski, Sara Stanley, Javier Valencia Huamani, Juan José Montenegro, Karla Tafur, Ana Bautista Julca, Frederick L. Altice

Published in: BMC Public Health | Issue 1/2024

Abstract

Background

In Peru, HIV cases are highly concentrated among men who have sex with men (MSM). Despite the availability of anti-retroviral therapy, people living with HIV (PWH) have higher levels of oral diseases. Alcohol use disorder (AUD) is significantly present among PWH. Our overarching goal was to generate foundational evidence on the association of AUD and oral health in MSM with HIV and enhance research capacity for future intersectional research on AUD, oral health and HIV. Our specific aim was to implement an on-site electronic data collection system through the use of a REDCap Mobile App in a low-middle income country (LMIC) setting.

Methods

Five validated surveys were utilized to gather data on demographics, medical history, HIV status, alcohol use, HIV stigma, perceived oral health status, and dietary supplement use. These surveys were developed in REDCap and deployed with the REDCap Mobile App, which was installed on ten iPads across two medical HIV clinics in Lima, Peru. REDCap app as well as the protocol for data collection were calibrated with feedback from trial participants and clinical research staff to improve clinical efficiency and participant experience.

Results

The mean age of participants (n = 398) was 35.94 ± 9.13y, of which 98.5% identified as male, and 85.7% identified as homosexual. 78.1% of participants binge drank, and 12.3% reported being heavy drinkers. After pilot testing, significant modifications to the structure and layout of the surveys were performed to improve efficiency and flow. The app was successfully deployed to replace cumbersome paper records and collected data was directly stored in a REDCap database.

Conclusions

The REDCap Mobile App was successfully used due to its ability to: (a) capture and store data offline, (b) timely translate between multiple languages on the mobile app interface, and (c) provide user-friendly interface with low associated costs and ample support.

Trial registration

1R56DE029639-01.

Harris PA, Delacqua G, Taylor R, Pearson S, Fernandez M, Duda SN. The REDCap Mobile Application: a data collection platform for research in regions or situations with internet scarcity. JAMIA Open. 2021;4(3). Cited 2023 Jan 7. Available from: https://pubmed.ncbi.nlm.nih.gov/8435658/.

Sanchez J, Lama JR, Kusunoki L, Manrique H, Goicochea P, Lucchetti A, et al. HIV-1, sexually transmitted infections, and sexual behavior trends among men who have sex with men in Lima. Peru J Acquir Immune Defic Syndr. 2007;44(5):578–85. Cited 2022 Dec 28. Available from: https://pubmed.ncbi.nlm.nih.gov/17279049/.CrossRefPubMed

Tabet S, Sanchez J, Lama J, Goicochea P, Campos P, Rouillon M, et al. HIV, syphilis and heterosexual bridging among Peruvian men who have sex with men. AIDS. 2002;16(9):1271–7. Cited 2022 Dec 28. Available from: https://pubmed.ncbi.nlm.nih.gov/12045493/.CrossRefPubMed

Jeanty Y, Cardenas G, Fox JE, Pereyra M, Diaz C, Bednarsh H, et al. Correlates of unmet dental care need among HIV-positive people since being diagnosed with HIV. Public Health Reports. 2012;127(Suppl 2):17. Cited 2022 Dec 28. Available from: https://pubmed.ncbi.nlm.nih.gov/3314389/.CrossRefPubMedPubMedCentral

Fox JE, Tobias CR, Bachman SS, Reznik DA, Rajabiun S, Verdecias N. Increasing access to oral health care for people living with HIV/AIDS in the U.S.: baseline evaluation results of the Innovations in Oral Health Care Initiative. Public Health Rep. 2012;127 Suppl 2(Suppl 2):5–16. Cited 2022 Dec 28. Available from: https://pubmed.ncbi.nlm.nih.gov/22547872/.CrossRefPubMed

Burger-Calderon R, Smith JS, Ramsey KJ, Webster-Cyriaque J. The Association between the history of HIV diagnosis and oral health. J Dent Res. 2016;95(12):1366–74. Cited 2022 Dec 28. Available from: https://pubmed.ncbi.nlm.nih.gov/27527399/.CrossRefPubMed

WHO. Global status report on alcohol and health 2018. Genebra: Organização Mundial da Saúde; 2018. World Health Organisation. 2018;478. Cited 2023 Jan 7. Available from: https://www.who.int/publications/i/item/9789241565639.

Gonzales P, Bachireddy C, Grieco A, Ding R, De Galvez Leon SJ, Ulrich A, et al. Viral suppression levels in men who have sex with men and transgender women with newly diagnosed HIV and alcohol use disorder in Peru: results from a randomized, double-blind, placebo-controlled trial using oral naltrexone. J Acquir Immune Defic Syndr (1988). 2022;89(4):462–71. Cited 2023 Mar 9. Available from: https://journals-lww-com.offcampus.lib.washington.edu/jaids/Fulltext/2022/04010/Viral_Suppression_Levels_in_Men_Who_Have_Sex_With.15.aspx.CrossRef

Ferro EG, Weikum D, Vagenas P, Copenhaver MM, Gonzales P, Peinado J, et al. alcohol use disorders negatively influence antiretroviral medication adherence among men who have sex with men in Peru. AIDS Care. 2015;27(1):93. Cited 2023 Mar 9. Available from: https://pubmed.ncbi.nlm.nih.gov/4221495/.CrossRefPubMed

10.

Manicone PF, Tarli C, Mirijello A, Raffaelli L, Vassallo GA, Antonelli M, et al. Dental health in patients affected by alcohol use disorders: a cross-sectional study. Eur Rev Med Pharmacol Sci. 2017;21(22):5021–7. Cited 2022 Dec 28. Available from: https://pubmed.ncbi.nlm.nih.gov/29228416/.PubMed

11.

Wang J, Lv J, Wang W, Jiang X. Alcohol consumption and risk of periodontitis: a meta-analysis. J Clin Periodontol. 2016;43(7):572–83. Cited 2022 Dec 28. Available from: https://pubmed.ncbi.nlm.nih.gov/27029013/.CrossRefPubMed

12.

Parry CD, Patra J, Rehm J. Alcohol consumption and non-communicable diseases: epidemiology and policy implications. Addiction (Abingdon, England). 2011;106(10):1718–24. Cited 2022 Dec 28. Available from: https://pubmed.ncbi.nlm.nih.gov/21819471/.CrossRefPubMedPubMedCentral

13.

Lemma S, Janson A, Persson LÅ, Wickremasinhe D, Källestål C. Improving quality and use of routine health information system data in low- and middle-income countries: A scoping review. PLoS One. 2020;15(10). Cited 2022 Dec 28. Available from: https://pubmed.ncbi.nlm.nih.gov/33031406/.

14.

Were MC, Kariuki J, Chepng’eno V, Wandabwa M, Ndege S, Braitstein P, et al. Leapfrogging paper-based records using handheld technology: experience from Western Kenya. Stud Health Technol Inform. 2010;160(Pt 1):525–9. Cited 2022 Dec 28. Available from: https://pubmed.ncbi.nlm.nih.gov/20841742/.PubMed

15.

Zeleke AA, Worku AG, Demissie A, Otto-Sobotka F, Wilken M, Lipprandt M, et al. Evaluation of electronic and paper-pen data capturing tools for data quality in a public health survey in a health and demographic surveillance site, Ethiopia: randomized controlled crossover health care information technology evaluation. JMIR Mhealth Uhealth. 2019;7(2):e10995. Cited 2022 Dec 28. Available from: https://mhealth.jmir.org/2019/2/e10995.CrossRefPubMedPubMedCentral

16.

Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)–a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377–81. Cited 2022 Dec 28. Available from: https://pubmed.ncbi.nlm.nih.gov/18929686/.CrossRefPubMed

17.

Marroquin Rivera A, Rosas-Romero JC, Castro SM, Suárez-Obando F, Aguilera-Cruz J, Bartels SM, et al. Implementing a Redcap-based research data collection system for mental health. Rev Colomb Psiquiatr (Eng ed). 2021;50 Suppl 1(Suppl 1):110–5. Cited 2023 Jan 7. Available from: https://pubmed-ncbi-nlm-nih-gov.offcampus.lib.washington.edu/34257053/.

18.

Odukoya O, Nenrot D, Adelabu H, Katam N, Christian E, Holl J, et al. Application of the research electronic data capture (REDCap) system in a low- and middle income country- experiences, lessons, and challenges. Health Technol (Berl). 2021;11(6):1297–304. Cited 2022 Dec 28. Available from: https://pubmed.ncbi.nlm.nih.gov/35251887/.CrossRefPubMedPubMedCentral

19.

Coll J, Videla S, Ganoza C, Ornelas A, Pérez S, Clotet B, et al. Early diagnosis of HIV infection among men who have sex with men in Lima (Peru). A prospective cohort study. Clin Microbiol Infect. 2018;24(7):793–5.CrossRefPubMed

20.

Lama JR, Ignacio RAB, Alfaro R, Rios J, Cartagena JG, Valdez R, et al. Clinical and immunologic outcomes after immediate or deferred antiretroviral therapy initiation during primary human immunodeficiency virus infection: the sabes randomized clinical study. Clin Infect Dis. 2021;72(6):1042. Cited 2023 Feb 25. Available from: https://pubmed.ncbi.nlm.nih.gov/7958774/.CrossRefPubMed

21.

Corey L, Gilbert PB, Juraska M, Montefiori DC, Morris L, Karuna ST, et al. Two randomized trials of neutralizing antibodies to prevent HIV-1 acquisition. N Engl J Med. 2021;384(11):1003. Cited 2023 Feb 25. Available from: https://pubmed.ncbi.nlm.nih.gov/8189692/.CrossRefPubMedPubMedCentral

22.

AUDIT : the Alcohol Use Disorders Identification Test : guidelines for use in primary health care. Cited 2023 Feb 25. Available from: https://www.who.int/publications/i/item/WHO-MSD-MSB-01.6a.

23.

Eke PI, Dye BA, Wei L, Slade GD, Thornton-Evans GO, Beck JD, et al. Self-reported measures for surveillance of periodontitis. J Dent Res. 2013;92(11):1041–7. Cited 2023 Mar 9. . Available from: https://pubmed-ncbi-nlm-nih-gov.offcampus.lib.washington.edu/24065636/.CrossRefPubMed

24.

Montero E, La Rosa M, Montanya E, Calle-Pascual AL, Genco RJ, Sanz M, et al. Validation of self-reported measures of periodontitis in a Spanish Population. J Periodontal Res. 2020;55(3):400–9. Cited 2023 Mar 9. Available from: https://pubmed-ncbi-nlm-nih-gov.offcampus.lib.washington.edu/31872881/.CrossRefPubMed

25.

Saka-Herrán C, Jané-Salas E, González-Navarro B, Estrugo-Devesa A, López-López J. Validity of a self-reported questionnaire for periodontitis in Spanish population. J Periodontol. 2020;91(8):1027–38. Cited 2023 Mar 9. Available from: https://pubmed-ncbi-nlm-nih-gov.offcampus.lib.washington.edu/31984491/.CrossRefPubMed

26.

Berger BE, Ferrans CE, Lashley FR. Measuring stigma in people with HIV: psychometric assessment of the HIV stigma scale. Res Nurs Health. 2001;24(6):518–29. Cited 2023 Feb 25. Available from: https://pubmed.ncbi.nlm.nih.gov/11746080/.CrossRefPubMed

Title: Implementation of REDCap mobile app in an oral HIV clinical study
Authors: Ana Lucia Seminario
Ashley E. Karczewski
Sara Stanley
Javier Valencia Huamani
Juan José Montenegro
Karla Tafur
Ana Bautista Julca
Frederick L. Altice
Publication date: 01-12-2024
Publisher: BioMed Central
Keyword: Human Immunodeficiency Virus
Published in: BMC Public Health / Issue 1/2024
Electronic ISSN: 1471-2458
DOI: https://doi.org/10.1186/s12889-024-17837-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Implementation of REDCap mobile app in an oral HIV clinical study

Abstract

Background

Methods

Results

Conclusions

Trial registration

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Trial registration

Please log in to get access to this content

Other articles of this Issue 1/2024

A rapid review of opportunities and challenges in the implementation of social prescription interventions for addressing the unmet needs of individuals living with long-term chronic conditions

Influence of academic involution atmosphere on college students’ stress response: the chain mediating effect of relative deprivation and academic involution

Heterogeneity in COVID-19 vaccine uptake within low-income minority communities: evidence from the watts neighborhood health study

Who continues to work after retirement age?

Longitudinal assessment of the relationship between frailty and social relationships among Japanese older adults: a random intercept cross-lagged panel model

Risk factors and their association network for young adults’ suicidality: a cross-sectional study