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Journal of NeuroVirology
Published in: Journal of NeuroVirology 6/2023

29-10-2023 | Human Immunodeficiency Virus | Review

Disruption of blood–brain barrier: effects of HIV Tat on brain microvascular endothelial cells and tight junction proteins

Authors: Yuqing Sun, Miaotian Cai, Ying Liang, Yulin Zhang

Published in: Journal of NeuroVirology | Issue 6/2023

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Abstract

Although the widespread use of antiretroviral therapy (ART) has prolonged the life span of people living with HIV (PLWH), the incidence of HIV-associated neurocognitive disorders (HAND) in PLWH is also gradually increasing, seriously affecting the quality of life for PLWH. However, the pathogenesis of HAND has not been elucidated, which leaves HAND without effective treatment. HIV protein transactivator of transcription (Tat), as an important regulatory protein, is crucial in the pathogenesis of HAND, and its mechanism of HAND has received widespread attention. The blood–brain barrier (BBB) and its cellular component brain microvascular endothelial cells (BMVECs) play a necessary role in protecting the central nervous system (CNS), and their damage associated with Tat is a potential therapeutic target of HAND. In this review, we will study the Tat-mediated damage mechanism of the BBB and present multiple lines of evidence related to BMVEC damage caused by Tat.
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Metadata
Title
Disruption of blood–brain barrier: effects of HIV Tat on brain microvascular endothelial cells and tight junction proteins
Authors
Yuqing Sun
Miaotian Cai
Ying Liang
Yulin Zhang
Publication date
29-10-2023
Publisher
Springer International Publishing
Published in
Journal of NeuroVirology / Issue 6/2023
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI
https://doi.org/10.1007/s13365-023-01179-3

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