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17-04-2024 | Human Immunodeficiency Virus | Original Article

Exploring the feasibility, acceptability and preliminary effects of a nurse delivered mhealth intervention for women living with HIV in South India: a pilot randomized controlled trial

Authors: Veena A. Satyanarayana, Mona Duggal, Sangchoon Jeon, Pushpendra Singh, Anita Desai, Prabha S. Chandra, Nancy R. Reynolds

Published in: Archives of Women's Mental Health

Abstract

Purpose

We evaluated the feasibility, acceptability and preliminary efficacy of a standardized nurse delivered mobile phone intervention to improve adherence to antiretroviral treatment and clinical outcomes.

Methods

Feasibility and acceptability of the phone intervention was assessed with rates of eligibility, completed visits, and attritions. Intervention fidelity was assessed by checking recorded calls and feedback. Efficacy was assessed using a randomized controlled trial in which 120 women living with HIV and psychosocial vulnerabilities, were randomized to Treatment as Usual (TAU = 60) or TAU plus the mobile phone intervention (N = 60). Trained basic nurses delivered the theory-guided, standardized mobile phone intervention for mental health issues and psychosocial risk factors to improve antiretroviral treatment (ART) adherence and retention in care and improve clinical outcomes. Blind raters performed the assessments at 6, 12 and 24 weeks post-randomization.

Results

Adherence diminished over time in the TAU only group, while it was sustained in the TAU Plus group, only dropping at 24 weeks after the intervention had been discontinued. Among participants with depressive symptoms (CESD ≥ 16), the intervention had significant improvement in adherence rates (p < 0.01), psychological quality of life (p < 0.05) and illness perception (p < 0.05) compared to those in the TAU only group. Greater improvements of quality of life subscales were observed in the TAU Plus group among participants with less psychological vulnerability (PSV < 2). HIV RNA was not significantly different between the groups at week 24.

Conclusions

The mobile-delivered counseling intervention was feasible and acceptable and shows promise among women living with HIV and psychosocial vulnerabilities in rural South India.

Trial Registration

ClinicalTrials.gov Identifier: NCT02319330 [Registered on: December 18, 2014].

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Title: Exploring the feasibility, acceptability and preliminary effects of a nurse delivered mhealth intervention for women living with HIV in South India: a pilot randomized controlled trial
Authors: Veena A. Satyanarayana
Mona Duggal
Sangchoon Jeon
Pushpendra Singh
Anita Desai
Prabha S. Chandra
Nancy R. Reynolds
Publication date: 17-04-2024
Publisher: Springer Vienna
Keywords: Human Immunodeficiency Virus
Affective Disorder
Affective Disorder
Published in: Archives of Women's Mental Health
Print ISSN: 1434-1816
Electronic ISSN: 1435-1102
DOI: https://doi.org/10.1007/s00737-024-01462-0

At a glance: The STEP trials

Springer Medicine

Exploring the feasibility, acceptability and preliminary effects of a nurse delivered mhealth intervention for women living with HIV in South India: a pilot randomized controlled trial

Abstract

Purpose

Methods

Results

Conclusions

Trial Registration

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

Trial Registration

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