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01-05-2019 | Pictorial Essay

Human immunodeficiency virus-related cerebral white matter disease in children

Authors: Christelle Ackermann, Ronald van Toorn, Savvas Andronikou

Published in: Pediatric Radiology | Issue 5/2019

Abstract

The human immunodeficiency virus (HIV) epidemic seems largely controlled by anti-retroviral treatment with resultant large numbers of children growing up with the disease on long-term treatment, placing them at higher risk to develop HIV-related brain injury, ongoing cognitive impairment and treatment-related neurological complications. Cerebral white matter involvement is a common radiologic finding in HIV infection and the causes of this have overlapping appearances, ranging from diffuse widespread involvement to focal lesions. The varied pathophysiology is broadly grouped into primary effects of HIV, opportunistic infection, vascular disease and neoplasms. White matter changes in children can be different from those in adults. This review provides guidance to radiologists with the diagnostic dilemma of nonspecific cerebral white matter lesions in children with HIV. The authors discuss common causes of HIV-related cerebral white matter disease as well as the role of neuroimaging in the management of these children.

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Title: Human immunodeficiency virus-related cerebral white matter disease in children
Authors: Christelle Ackermann
Ronald van Toorn
Savvas Andronikou
Publication date: 01-05-2019
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Radiology / Issue 5/2019
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-018-4310-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Human immunodeficiency virus-related cerebral white matter disease in children

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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