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Journal of Assisted Reproduction and Genetics

Published in:

01-06-2009 | ASSISTED REPRODUCTION

Human choriogonadotropin prior to controlled ovarian stimulation and in vitro fertilization improves implantation, and pregnancy rates

Authors: Eduardo L. Motta, Gary D. Smith, Paulo C. Serafini, Marcio Coslovsky, Pericles Hassun, Andre M. Rocha, Isaac Yadid

Published in: Journal of Assisted Reproduction and Genetics | Issue 6/2009

Abstract

Purpose

Our purpose was to retrospectively compare controlled ovarian stimulation(COH) in IVF cycles with administration of hCG on the day of menses (D1-hCG) with women not receiving hCG at day 1 of menses (Control).

Methods

Data on maternal age, endocrine profile, amount of rFSH required, embryo characteristics, implantation and pregnancy rates were recorded for comparison between D1-hCG (n = 36) and Control (n = 64).

Results

Dose of rFSH required to accomplish COH was significantly lower in D1-hCG. Following ICSI, more top-quality embryos were available for transfer per patient in the D1-hCG and biochemical pregnancy rates per transfer were significantly higher in the D1-hCG. Significantly higher implantation and on-going pregnancy rates per embryo transfer were observed in D1-hCG (64%) compared to Control (41%).

Conclusions

Administration of D1-hCG prior to COH reduces rFSH use and enhances oocyte developmental competence to obtain top quality embryos, and improves implantation and on-going pregnancy rates. At present it is not clear if the benefit is related to producing an embryo that more likely to implant or a more receptive uterus, or merely fortuitous and related to the relatively small power of the study.

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Title: Human choriogonadotropin prior to controlled ovarian stimulation and in vitro fertilization improves implantation, and pregnancy rates
Authors: Eduardo L. Motta
Gary D. Smith
Paulo C. Serafini
Marcio Coslovsky
Pericles Hassun
Andre M. Rocha
Isaac Yadid
Publication date: 01-06-2009
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 6/2009
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-009-9322-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Human choriogonadotropin prior to controlled ovarian stimulation and in vitro fertilization improves implantation, and pregnancy rates

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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