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Current Dermatology Reports
Published in: Current Dermatology Reports 4/2016

01-12-2016 | Wound Care and Healing (A Friedman, Section Editor)

Human as the Ultimate Wound Healing Model: Strategies for Studies Investigating the Dermal Lipidome

Authors: Dayanjan S. Wijesinghe, Urszula Osinska Warncke, Robert F. Diegelmann

Published in: Current Dermatology Reports | Issue 4/2016

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Abstract

Purpose of Review

The purpose of this review was to educate the reader of the multiple roles undertaken by the human epidermal lipidome and the experimental techniques of measuring them.

Recent Findings

Damage to skin elicits a wound healing process that is capped by the recreation of the lipid barrier. In addition to barrier function, lipids also undertake an active signaling role during wound healing. Achievement of these multiple functions necessitates a significant complexity and diversity in the lipidome resulting in a composition that is unique to the human skin. As such, any attempts to delineate the function of the lipidome during the wound healing process in humans need to be addressed via studies undertaken in humans.

Summary

The human cutaneous lipidome is unique and plays a functionally significant role in maintaining barrier and regulating wound healing. Modern mass spectrometry and Raman spectroscopy-based methods enable the investigation of epidermal lipidome with respect to those functions.
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Metadata
Title
Human as the Ultimate Wound Healing Model: Strategies for Studies Investigating the Dermal Lipidome
Authors
Dayanjan S. Wijesinghe
Urszula Osinska Warncke
Robert F. Diegelmann
Publication date
01-12-2016
Publisher
Springer US
Published in
Current Dermatology Reports / Issue 4/2016
Electronic ISSN: 2162-4933
DOI
https://doi.org/10.1007/s13671-016-0156-3

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