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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2012

01-02-2012 | Editorial

How does BAFF activate B cells in patients with autoimmune diseases?

Author: Xavier Mariette

Published in: Arthritis Research & Therapy | Issue 1/2012

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Abstract

In a study in a recent issue of Arthritis Research & Therapy, Yoshimoto and colleagues demonstrate that peripheral monocytes from patients with Sjögren's syndrome (SS) produce significantly higher amounts of B cell-activating factor (BAFF) and interleukin-6 (IL-6) in comparison with normal monocytes. This difference exists at baseline and is amplified after stimulation with interferon-gamma. Increased IL-6 secretion is partially suppressed by an anti-BAFF antibody, suggesting that signal transduction pathways mediated by BAFF are implicated in the regulation of IL-6 production by monocytes. The origin and pathways involved in this higher susceptibility to BAFF-driven IL-6 induction by monocytes of patients with SS are still unknown.
Literature
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Ittah M, Miceli-Richard C, Eric Gottenberg J, Lavie F, Lazure T, Ba N, Sellam J, Lepajolec C, Mariette X: B cell-activating factor of the tumor necrosis factor family (BAFF) is expressed under stimulation by interferon in salivary gland epithelial cells in primary Sjogren's syndrome. Arthritis Res Ther. 2006, 8: R51-10.1186/ar1912.PubMedCentralCrossRefPubMed
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Lavie F, Miceli-Richard C, Quillard J, Roux S, Leclerc P, Mariette X: Expression of BAFF (BLyS) in T cells infiltrating labial salivary glands from patients with Sjogren's syndrome. J Pathol. 2004, 202: 496-502. 10.1002/path.1533.CrossRefPubMed
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Sellam J, Miceli-Richard C, Gottenberg JE, Ittah M, Lavie F, Lacabaratz C, Gestermann N, Proust A, Lambotte O, Mariette X: Decreased B cell activating factor receptor expression on peripheral lymphocytes associated with increased disease activity in Dis primary Sjögren's syndrome and systemic lupus erythematosus. Ann Rheum. 2007, 66: 790-797. 10.1136/ard.2006.065656.CrossRef
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Metadata
Title
How does BAFF activate B cells in patients with autoimmune diseases?
Author
Xavier Mariette
Publication date
01-02-2012
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 1/2012
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3729

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Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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