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Archives of Virology
Published in: Archives of Virology 4/2008

01-04-2008 | Brief Report

HN protein of Newcastle disease virus causes apoptosis in chicken embryo fibroblast cells

Authors: P. V. Ravindra, Ashok K. Tiwari, Bhaskar Sharma, Yogendra Singh Rajawat, Barkha Ratta, Sudesh Palia, N. R. Sundaresan, Uttara Chaturvedi, G. B. Aruna Kumar, Kantaraja Chindera, Meeta Saxena, P. K. Subudhi, Anant Rai, R. S. Chauhan

Published in: Archives of Virology | Issue 4/2008

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Abstract

Newcastle disease virus (NDV), an avian paramyxovirus, induces apoptosis in chicken embryo fibroblast (CEF) cells. In the present investigation, the ability of haemagglutinin-neuraminidase (HN) protein of NDV to cause apoptosis in CEF cells was examined. The results revealed that cells expressing the HN protein demonstrated decreased DNA content, phosphatidylserine exposure and increased cytoplasmic vacuolation. Up-regulation of caspase-1, -9, -8, -3, loss of mitochondrial transmembrane potential and an increase in oxidative stress were also observed in cells expressing the HN protein. Based on the above results it can be concluded that HN protein of NDV causes apoptosis in CEF cells.
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Metadata
Title
HN protein of Newcastle disease virus causes apoptosis in chicken embryo fibroblast cells
Authors
P. V. Ravindra
Ashok K. Tiwari
Bhaskar Sharma
Yogendra Singh Rajawat
Barkha Ratta
Sudesh Palia
N. R. Sundaresan
Uttara Chaturvedi
G. B. Aruna Kumar
Kantaraja Chindera
Meeta Saxena
P. K. Subudhi
Anant Rai
R. S. Chauhan
Publication date
01-04-2008
Publisher
Springer Vienna
Published in
Archives of Virology / Issue 4/2008
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-008-0057-2

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